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New genes and old genes contribute to personality traits

A polymorphic region in the human transcription factor AP-2beta gene is associated with specific personality traits

The authors suggest a novel approach in the elucidation of the genetic part of psychiatric disorders and personality; i.e., to identify transcription factor genes as candidate genes in psychiatric disorders and personality. In support of this notion, they show, in the current study, that the personality traits muscular tension, guilt, somatic anxiety, psychasthenia and indirect aggression, as estimated by the Karolinska Scales of Personality (KSP) are significantly related to transcription factor AP-2beta genotype. Since important genes encoding proteins in the dopaminergic and serotonergic system have binding sites for AP-2 in their regulatory regions, one might speculate that the expression of different isoforms of AP-2 influences mood and personality, not only due to their role during the development of the brain, but also due to their function during adulthood.

AUTHORS: M Damberg, H Garpenstrand, J Alfredsson, J Ekblom, K Forslund, G Rylander, L Oreland
Department of Neuroscience, Unit of Pharmacology, Uppsala University, Uppsala, Sweden; Department of Clinical Neuroscience, Karolinska Hospital, Stockholm, Sweden

For further information on this work, please contact Professor Lars Oreland, Department of Neuroscience, Section of Pharmacology, BMC, PO Box 593, S-751 24 Uppsala, Sweden.
Tel: 46-18-471-4092
FAX: 46-18-471-4945
e-mail:lars.oreland@neuro.uu.se

Association and linkage of anxiety-related traits with a functional polymorphism of the serotonin transporter gene regulatory region in Israeli sibling pairs

The neurotransmitter serotonin is thought to play a key role in anxiety and depression and is the target for a very popular class of psychiatric drugs.

This study examined the relationship between a functional polymorphism in th
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Contact: Jill Merritt
merrittj@ucla.edu
310-206-6739
Molecular Psychiatry
7-May-2000


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