HOME >> BIOLOGY >> NEWS
New genetic technique delivers knockout blow to 'Asthma Virus'

The respiratory syncytial virus (RSV) is the major cause of asthma and respiratory illness in children, claiming around a million lives each year. New research published in BMC Microbiology reveals how synthetic inhibitory double stranded RNA (siRNA) can be used to knock out the function of specific RSV genes. This technique will be exceptionally useful in furthering understanding of RSV and related viruses. In addition, it could lead to the development of new treatments to combat such viruses.

Most organisms use double stranded DNA to store their genetic information. However, some viruses use single or double stranded RNA instead. Among those that use single stranded RNA are RSV and the viruses responsible for influenza, measles, mumps, rabies, lassa fever and ebola. These organisms present unique challenges to researchers, as they cannot be studied using conventional genetic techniques, which are designed for DNA.

Vira Bitko and Sailen Barik from the University of Alabama used a technique called "post-translational gene silencing" whereby specific siRNA molecules are synthesised and used to target specific regions of the virus RNA. The researchers found that when siRNA was introduced into virus-infected cells, the production of specific viral proteins were blocked and that replication of the virus could be efficiently suppressed. Furthermore, there was no detectable effect on the gene expression of the host cell confirming that the technique specific to the RNA virus. They were also able to show that siRNA acts by a mechanism that does not involve the interferon response that is triggered by viral infections.


'"/>

Contact: Gordon Fletcher
gordon@biomedcentral.com
44-20-7323-0323
BioMed Central
15-Jan-2002


Page: 1

Related biology news :

1. Researchers determine genetic cause of Timothy syndrome
2. Rare childhood genetic syndrome identified
3. New research shows plants can shuffle and paste gene pieces to generate genetic diversity
4. Scientists decipher genetic code of biothreat pathogen
5. Chemical genetics identifies SARS inhibitors
6. 22nd amino acid synthesized and added to genetic code of e. coli bacteria
7. The impact of genetic variations on the treatment of early rheumatoid arthritis
8. Adaptive changes in the genome may provide insight into the genetics of complex disease
9. New genetic hypothesis for the cause of autism
10. Fossils reveal direct link between global warming and genetic diversity in wildlife
11. A genetic disorder yields insight into genes and cognition

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/9/2017)... Australia , March 9, 2017 4Dx ... prestigious World Lung Imaging Workshop at the University of ... was invited to deliver the latest data to world ... recognised event brings together leaders at the forefront of ... in lung imaging. "The quality of ...
(Date:3/6/2017)... , March 6, 2017 Mintigo ... technology, today announced Predictive Sales Coach TM , ... actionable sales intelligence into Salesforce. This unique AI ... their sales organizations with deep knowledge of their ... for intelligent engagement. Predictive Sales Coach extends Mintigo,s ...
(Date:3/2/2017)... Australia , March 2, 2017 Australian ... Ltd (ASX: CYP), has signed an agreement with ... from the Monash Biomedicine Discovery Institute and Department of ... to conduct a further preclinical study to support the ... treatment of asthma.  Asthma is a ...
Breaking Biology News(10 mins):
(Date:3/27/2017)... Properties (NYSE: CUZ ) announced today that Amgen, ... 10-year, approximately 125,000 square-foot lease at Corporate Center, a 1,224,000 ... submarket of Tampa, FL. ... for their new location in Tampa ," ... of Cousins Properties. "Amgen is a cutting-edge global company at ...
(Date:3/27/2017)... DUBLIN , March 27, 2017 ... access to a comprehensive library of reports on Valero ... the transportation fuels and petrochemical industries. ...      (Logo: http://photos.prnewswire.com/prnh/20160330/349511LOGO) ... is biofuel production to go green. Ethanol today, even though ...
(Date:3/27/2017)... NEW YORK , March 27, 2017 /PRNewswire/ ... company developing novel therapies for neurodegenerative diseases, including ... confirmation that its application to list the Company,s ... been approved by The NASDAQ Stock Market, a ... of the listing, Neurotrope will ring the Opening Bell ...
(Date:3/24/2017)... 24, 2017 On Thursday, March ... at 5,817.69, down 0.07%; the Dow Jones Industrial Average ... S&P 500 closed at 2,345.96, marginally dropping 0.11%. US ... in green, 4 sectors finished in red, and 1 ... has initiated reports coverage on the following Biotechnology equities: ...
Breaking Biology Technology:
Cached News: