HOME >> BIOLOGY >> NEWS
New genetic technique delivers knockout blow to 'Asthma Virus'

The respiratory syncytial virus (RSV) is the major cause of asthma and respiratory illness in children, claiming around a million lives each year. New research published in BMC Microbiology reveals how synthetic inhibitory double stranded RNA (siRNA) can be used to knock out the function of specific RSV genes. This technique will be exceptionally useful in furthering understanding of RSV and related viruses. In addition, it could lead to the development of new treatments to combat such viruses.

Most organisms use double stranded DNA to store their genetic information. However, some viruses use single or double stranded RNA instead. Among those that use single stranded RNA are RSV and the viruses responsible for influenza, measles, mumps, rabies, lassa fever and ebola. These organisms present unique challenges to researchers, as they cannot be studied using conventional genetic techniques, which are designed for DNA.

Vira Bitko and Sailen Barik from the University of Alabama used a technique called "post-translational gene silencing" whereby specific siRNA molecules are synthesised and used to target specific regions of the virus RNA. The researchers found that when siRNA was introduced into virus-infected cells, the production of specific viral proteins were blocked and that replication of the virus could be efficiently suppressed. Furthermore, there was no detectable effect on the gene expression of the host cell confirming that the technique specific to the RNA virus. They were also able to show that siRNA acts by a mechanism that does not involve the interferon response that is triggered by viral infections.


'"/>

Contact: Gordon Fletcher
gordon@biomedcentral.com
44-20-7323-0323
BioMed Central
15-Jan-2002


Page: 1

Related biology news :

1. Researchers determine genetic cause of Timothy syndrome
2. Rare childhood genetic syndrome identified
3. New research shows plants can shuffle and paste gene pieces to generate genetic diversity
4. Scientists decipher genetic code of biothreat pathogen
5. Chemical genetics identifies SARS inhibitors
6. 22nd amino acid synthesized and added to genetic code of e. coli bacteria
7. The impact of genetic variations on the treatment of early rheumatoid arthritis
8. Adaptive changes in the genome may provide insight into the genetics of complex disease
9. New genetic hypothesis for the cause of autism
10. Fossils reveal direct link between global warming and genetic diversity in wildlife
11. A genetic disorder yields insight into genes and cognition

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/3/2017)...  Texas Biomedical Research Institute announced that its Board of ... as the Institute,s new President and CEO. Dr. Schlesinger will ... He is currently the Chair of the Department of Microbial ... Interface Biology at Ohio State University. "We are ... CEO of Texas Biomed," said Dr. James O. Rubin ...
(Date:2/2/2017)...  Central to its deep commitment to honor ... Japan Prize Foundation today announced the laureates of ... envelope in their respective fields of Life Sciences ... being recognized with the 2017 Japan Prize for ... to the advancement of science and technology, but ...
(Date:1/26/2017)... Jan. 26, 2017  Crossmatch, a leading provider of ... solution aimed at combatting fraud, waste and abuse in ... at the Action on Disaster Relief conference in ... for UN agencies and foreign assistance organizations throughout ... and abuse are a largely unacknowledged problem in the ...
Breaking Biology News(10 mins):
(Date:2/22/2017)... Feb. 22, 2017 Scientists propose in ... organ damage in Gaucher and maybe other lysosomal storage ... lower costs than current therapies. An international ... Center , which also included investigators from the University ... their data Feb. 22. The study was conducted in ...
(Date:2/22/2017)... ... ... LabRoots , the leading provider of educational and interactive virtual events ... the launch of a new scholarship for young scientists seeking a degree in any ... open to all high school seniors, 17 years or older; as well as those ...
(Date:2/22/2017)... ... February 22, 2017 , ... NDA Partners Chairman ... former Acting Deputy Director in the FDA CDRH Division of Cardiovascular, Respiratory, and ... the company as an Expert Consultant. , In Dr. Spyker’s accomplished career, he ...
(Date:2/21/2017)... , Feb. 21, 2017 Synthetic Biologics, Inc. ... to preserve the microbiome to protect and restore the health of ... year ended December 31, 2016 on Thursday, March 2, 2017, and ... EST. The dial-in information for the call is as follows: ... ...
Breaking Biology Technology:
Cached News: