HOME >> BIOLOGY >> NEWS
New genomics tool boosts diabetes research

CAMBRIDGE, Mass. (Feb. 26, 2004) Researchers have developed a method for scanning the entire human genome to successfully map the location of key gene regulators, mutated forms of which are known to cause type 2 diabetes. The research marks the first time that human organs, in this case the pancreas and liver, have been analyzed in this way and opens the door to similar studies of other organ systems and diseases.

The work, published in the Feb. 27 issue of the journal Science, could lead to new approaches for developing medications and assessing a person's genetic risk to this and other conditions, says Richard Young, a scientist at Whitehead Institute for Biomedical Research and lead researcher on the project.

Key to understanding the relationship between genes and disease are gene regulators called transcription factors, proteins that bind to specific areas of the genome and act to switch genes on and off. To discover how a specific transcription factor might contribute to a particular disease, scientists must locate each point in the genome where the transcription factor adheres and identify the individual genes it controls. Using conventional tools, it might take a single scientist a lifetime to do this for just one transcription factor. Yet humans have over 1,000 transcription factors and dozens of these have been linked to diseases.

"We developed an efficient gene-scanning technology so we could map genome binding sites for many transcription factors in a human organ," says Duncan Odom, a postdoctoral fellow at Whitehead Institute and lead author of the paper. "This allows us to identify the sets of genes where transcription factors act as switches and to learn how defects in these switches might cause disease".

In October 2002, a team led by Young, who also is a professor of biology at Massachusetts Institute of Technology, reported in Science on a technology used to identify how over 100 transcription factors were associated
'"/>

Contact: David Cameron
newsroom@wi.mit.edu
617-258-5183
Whitehead Institute for Biomedical Research
26-Feb-2004


Page: 1 2 3

Related biology news :

1. International symposium on nutritional genomics
2. APS announces the winners of its 2004 postdoctoral fellowship in physiological genomics
3. Full promise of genomics in disease research yet to be realized
4. Pharmacogenomics could replace trial-and-error with science from the human genome
5. Dartmouth Medical School awarded $9 million grant for genomics research
6. Functional genomics enables easy target identification and drives drug discovery
7. Library on a Slide: Whole genome microarrays for comparative genomics
8. Bacteriophage genomics approach to antimicrobial drug discovery published in Nature Biotechnology
9. Emerging frontiers genomics grant for blue-green bacteria
10. What can the genomics revolution teach us about global change?
11. Hot topics in pharmacogenomics

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/11/2020)... ... February 11, 2020 , ... ... to announce it achieved its ISO 9001:2015 registration by certification body Intertek. Modality ... audits, she reviewed and revised all existing Standard Operating Procedures (SOPs) and created ...
(Date:2/7/2020)... ... 2020 , ... dicentra , a leading clinical research ... dietary supplement industries, announces 2020 membership with the International Probiotics Association (“IPA”). ... to probiotics. We are thrilled to join our IPA member colleagues and bring ...
(Date:2/5/2020)... ... February 05, 2020 , ... LabKey has released Sample Manager, ... to sample processing within laboratories. , Built with input from a Product ... fields, LabKey Sample Manager has been designed with an intuitive user interface providing ...
Breaking Biology News(10 mins):
(Date:1/24/2020)... ... January 24, 2020 , ... Sierra ... mass flow meters and controllers ideal for BioPharm OEMS. Sierra also ... antiquated rotameters. These thermal instruments employ high-precision MEMS (Micro-Electro Mechanical Systems) technology utilizing ...
(Date:1/22/2020)... , ... January 20, 2020 , ... ... a partnership with WAVE Electronics, the largest independent electronics distributor in the US, ... purchase Brilliant Smart Home Systems with leading smart home products from a single ...
(Date:1/22/2020)... ... January 21, 2020 , ... COBO Technologies and ... editing. The partners have agreed to co-develop and market a portfolio of CRISPR ... pre-clinical programs. Over the longer-term, the parties aim to develop a COBO branded ...
(Date:1/10/2020)... ... January 09, 2020 , ... A new report ... for the vendor qualification process, a critical element of clinical trial set up ... of the vendor qualification process creates delays in initiation in 7% of clinical ...
Breaking Biology Technology:
Cached News: