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New insight into cancer metastasis

hardson can see the potential for developing a Twist inhibitor, a drug that wouldn't kill a tumor but rather stop its metastatic capabilities. "Something like that would turn cancer into a chronic disease, rather than a deadly one," she suggests.

Yang also can see potential to apply these findings diagnostically. "With breast cancer patients diagnosed with a primary tumor, it's hard to tell whether or not that tumor will generate metastases," she says. "Some small tumors will metastasize, some large ones won't. Here we might be able to discover if a tumor is ready to invade and metastasize or not by finding out if the Twist gene is on or off."

For now, the discovery of Twist is only the beginning. Says Weinberg, "There are a number of other regulatory proteins that have been studied in other labs and have properties very similar to those of Twist. The other regulators undoubtedly will play important roles in other types of human metastatic cancer."


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Contact: David Cameron
newsroom@wi.mit.edu
617-258-5183
Whitehead Institute for Biomedical Research
24-Jun-2004


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