HOME >> BIOLOGY >> NEWS
New insights into cause of stomach cancer

Australian scientists have discovered a vital clue to the causes of stomach cancer and inflammatory bowel disease.

Stomach cancer is the fourth most common form of cancer death in Australia and the second most common in parts of South Asia including Japan and Korea. Until now, little was known about what caused this disease, which is difficult to treat and usually incurable.

The team's discovery, a collaborative effort largely between the University of Melbourne and the Ludwig Institute for Cancer Research in Melbourne, has identified the possible targets for the development of drugs to treat these diseases. The research will be published in the October edition of the journal, Nature Medicine.

Using mice, Dr Matthias Ernst at the Ludwig and Associate Professor Andy Giraud from the University of Melbourne (Western Hospital) found the clue when they made specific mutations to a molecule found on the surface of cells that is traditionally involved in helping regulate the body's immune system.

The receptor molecule called, gp130, acts as a molecular 'antenna', to transmit instructions to individual cells from soluble messenger molecules called cytokines found in the circulation and body fluids. This message service is what tells the cell how to respond to its environment.

Ernst and Giraud were surprised when the mice carrying mutations in gp130 developed cellular changes and other symptoms that mirrored those of gastric cancer and large bowel inflammation in humans.

Previous research in the USA and Japan has largely dismissed the regulatory role that gp130 plays in the protection of the digestive tract against stomach cancer and some forms of inflammatory bowel disease.

"Nobody suspected that interference with the messenger service engaged by gp130 could be linked with a 100 percent prevalence of early stages of gastric cancer in mice," says Giraud.

"Drug treatment is years away, but now that we have b
'"/>

Contact: Jason Major
jmajor@unimelb.edu.au
61-38-344-0181
University of Melbourne
12-Sep-2002


Page: 1 2 3

Related biology news :

1. Heart gene yields insights into evolution, disease risk
2. Two-month study of life in mid-Atlantic yields trove of species, new insights & questions
3. New survey reveals insights into unique relationship between mothers and pediatricians
4. Study yields insights into precancerous condition
5. Mutant mice lead to memory insights
6. Study of proteins offers insights into organization of biological networks
7. Common worm provides insights into salmonella virulence
8. Discovery in parasite movement may offer insights into malaria
9. New insights on sirtuins, involved in gene expression and aging
10. Rapidly evolving genes providing new insights in plant evolution
11. Yeast model yields insights into Parkinsons disease

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New insights into cause stomach cancer

(Date:3/17/2015)... Minn. , March 17, 2015 ... technology company specializing in clinical study management systems, ... be in attendance at ARENA,s Outsourcing in Clinical ... NC.  This event provides an excellent forum for ... easy-to-use, flexible and affordable software-as-a-service (SaaS) eClinical technology ...
(Date:3/12/2015)... , March 12, 2015 The mascots of ... Children,s Hospital, part of Wake Forest Baptist Medical Center. ... for the 2015 ACC Men,s Basketball Tournament. Young patients ... them and getting their autographs. Brenner Children,s ... It is the only children,s hospital in northwest ...
(Date:3/10/2015)... 2015  Continuing its 167-year history of offering the ... The Eye Scanning Password Authenticator , a device ... secure websites or sensitive data. Employing the ... borders, the device has a small camera that scans ... iris, converting them into an encrypted ID that cannot ...
Breaking Biology News(10 mins):Connect With MedNet Solutions At Outsourcing In Clinical Trials Southeast 2Hammacher Schlemmer Introduces The Eye Scanning Password Authenticator 2
(Date:3/25/2015)... 2015 /PRNewswire/ - SQI Diagnostics Inc. ("SQI" or the "Company") ... of recent discussions with certain shareholders representing approximately 45% ... after dealing with certain matters including the appointment of ... on March 26, 2015 (the "Meeting") it intends to ... will take place when the Meeting reconvenes. The Meeting ...
(Date:3/25/2015)... 25, 2015  S&P Capital IQ (MHFI) announced ... Report coverage on Abattis Bioceuticals Corp . ... is a specialty biotechnology company with capabilities through ... marketing proprietary ingredients, bio-similar compounds, patented equipment and ... North America . The company seeks to ...
(Date:3/25/2015)... , CAMBRIDGE, Mass. and ... NextCODE, which provides comprehensive capabilities for using the genome to ... on their publication of the largest studies of whole-genome data ... online in Nature Genetics – are ... sequence variation, authored by a team of deCODE scientists led ...
(Date:3/25/2015)... CA (PRWEB) March 25, 2015 ... for Novel Mechanism of Action in Neuromuscular Diseases ... 2015 – Cytokinetics, Incorporated (Nasdaq: CYTK) announced the ... skeletal muscle troponin activator tirasemtiv in the journal ... Phase IIa “Evidence of Effect” or hypothesis-generating clinical ...
Breaking Biology Technology:SQI Diagnostics Inc. Announces New Nominees to SQI Diagnostics Board and Adjournment of Meeting 2SQI Diagnostics Inc. Announces New Nominees to SQI Diagnostics Board and Adjournment of Meeting 3SQI Diagnostics Inc. Announces New Nominees to SQI Diagnostics Board and Adjournment of Meeting 4SQI Diagnostics Inc. Announces New Nominees to SQI Diagnostics Board and Adjournment of Meeting 5S&P Capital IQ Initiates Coverage on Abattis Bioceuticals Corp. in S&P Capital IQ Factual Stock Reports 2S&P Capital IQ Initiates Coverage on Abattis Bioceuticals Corp. in S&P Capital IQ Factual Stock Reports 3S&P Capital IQ Initiates Coverage on Abattis Bioceuticals Corp. in S&P Capital IQ Factual Stock Reports 4S&P Capital IQ Initiates Coverage on Abattis Bioceuticals Corp. in S&P Capital IQ Factual Stock Reports 5Landmark deCODE Studies Demonstrate the Power of Truly Big Genomics for Improving Medicine Worldwide 2Cytokinetics Announces Publication of Results from Phase II Trial of Tirasemtiv in Patients with Myasthenia Gravis 2Cytokinetics Announces Publication of Results from Phase II Trial of Tirasemtiv in Patients with Myasthenia Gravis 3Cytokinetics Announces Publication of Results from Phase II Trial of Tirasemtiv in Patients with Myasthenia Gravis 4Cytokinetics Announces Publication of Results from Phase II Trial of Tirasemtiv in Patients with Myasthenia Gravis 5Cytokinetics Announces Publication of Results from Phase II Trial of Tirasemtiv in Patients with Myasthenia Gravis 6
Cached News: