HOME >> BIOLOGY >> NEWS
New insights into cause of stomach cancer

Australian scientists have discovered a vital clue to the causes of stomach cancer and inflammatory bowel disease.

Stomach cancer is the fourth most common form of cancer death in Australia and the second most common in parts of South Asia including Japan and Korea. Until now, little was known about what caused this disease, which is difficult to treat and usually incurable.

The team's discovery, a collaborative effort largely between the University of Melbourne and the Ludwig Institute for Cancer Research in Melbourne, has identified the possible targets for the development of drugs to treat these diseases. The research will be published in the October edition of the journal, Nature Medicine.

Using mice, Dr Matthias Ernst at the Ludwig and Associate Professor Andy Giraud from the University of Melbourne (Western Hospital) found the clue when they made specific mutations to a molecule found on the surface of cells that is traditionally involved in helping regulate the body's immune system.

The receptor molecule called, gp130, acts as a molecular 'antenna', to transmit instructions to individual cells from soluble messenger molecules called cytokines found in the circulation and body fluids. This message service is what tells the cell how to respond to its environment.

Ernst and Giraud were surprised when the mice carrying mutations in gp130 developed cellular changes and other symptoms that mirrored those of gastric cancer and large bowel inflammation in humans.

Previous research in the USA and Japan has largely dismissed the regulatory role that gp130 plays in the protection of the digestive tract against stomach cancer and some forms of inflammatory bowel disease.

"Nobody suspected that interference with the messenger service engaged by gp130 could be linked with a 100 percent prevalence of early stages of gastric cancer in mice," says Giraud.

"Drug treatment is years away, but now that we have b
'"/>

Contact: Jason Major
jmajor@unimelb.edu.au
61-38-344-0181
University of Melbourne
12-Sep-2002


Page: 1 2 3

Related biology news :

1. Heart gene yields insights into evolution, disease risk
2. Two-month study of life in mid-Atlantic yields trove of species, new insights & questions
3. New survey reveals insights into unique relationship between mothers and pediatricians
4. Study yields insights into precancerous condition
5. Mutant mice lead to memory insights
6. Study of proteins offers insights into organization of biological networks
7. Common worm provides insights into salmonella virulence
8. Discovery in parasite movement may offer insights into malaria
9. New insights on sirtuins, involved in gene expression and aging
10. Rapidly evolving genes providing new insights in plant evolution
11. Yeast model yields insights into Parkinsons disease

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New insights into cause stomach cancer

(Date:7/30/2014)... A group of researchers from the University of Helsinki ... experimentally to reproduce in mice morphological changes which have ... gradual modifications in the embryonic development of mice teeth, ... morphologically are very similar to those observed in the ... millions of years ago. , To modify the ...
(Date:7/30/2014)... is pleased to announce its new relationship with the ... and CINP will partner to publish International Journal ... open-access journal. , Alan Frazer, Editor-in-Chief of IJNP ... expertise of OUP will further facilitate the goal for ... very leading journals within neuropsychopharmacology. The conversion of the ...
(Date:7/30/2014)... $1 million from the Cornelia Cogswell Rossi Foundation to ... , The newly established Connie Cogswell Rossi ... a greater breadth and depth of knowledge of neurobehavioral ... of research to improve human health. , The new ... Laboratory and its external partners, supporting research to enhance ...
Breaking Biology News(10 mins):Scientists reproduce evolutionary changes by manipulating embryonic development of mice 2OUP to partner with the International College of Neuropsychopharmacology 2Rossi Foundation pledges $1M for JAX neurobehavioral research center 2
(Date:7/30/2014)... (PRWEB) July 30, 2014 ... of leading Immunologists, Principle Investigators, scientists in the ... J Malemud, Professor at Case Western Reserve University ... his keynote address on “The effects of ... production of matrix metalloproteinase-9”. Arya Biragyn, a Senior ...
(Date:7/29/2014)... 2014 SoundConnect , an ... is proud to announce the strategic additions of ... their Boston, Charleston and Atlanta offices. SoundConnect’s ... demand for hosted solutions, collaboration and mobility that ... cost. , SoundConnect was founded in 2004, with ...
(Date:7/29/2014)... have hurdled a number of significant technological challenges ... observing technology originally created for the James Webb ... Investigator Harvey Moseley, a scientist at NASA,s Goddard ... that electrostatically actuated microshutter arrays that is, ... are as functional as the current technology,s magnetically ...
(Date:7/29/2014)... DIEGO , July 29, 2014   Sequenom, ... sciences company that provides innovative genetic analysis solutions, and ... of esoteric laboratory services in the United ... noninvasive prenatal testing patents and applications. "We ... innovation, and patient care, and we welcome the opportunity ...
Breaking Biology Technology:Unveiling Breakthroughs in Clinical & Cellular Immunology 2Unveiling Breakthroughs in Clinical & Cellular Immunology 3SoundConnect Organization and Culture is Evolving 2Revolutionary microshutter technology hurdles significant challenges 2Revolutionary microshutter technology hurdles significant challenges 3Revolutionary microshutter technology hurdles significant challenges 4Sequenom Enters Into License Agreement With Mayo Medical Laboratories 2Sequenom Enters Into License Agreement With Mayo Medical Laboratories 3Sequenom Enters Into License Agreement With Mayo Medical Laboratories 4
Cached News: