New insights into cause of stomach cancer

Australian scientists have discovered a vital clue to the causes of stomach cancer and inflammatory bowel disease.

Stomach cancer is the fourth most common form of cancer death in Australia and the second most common in parts of South Asia including Japan and Korea. Until now, little was known about what caused this disease, which is difficult to treat and usually incurable.

The team's discovery, a collaborative effort largely between the University of Melbourne and the Ludwig Institute for Cancer Research in Melbourne, has identified the possible targets for the development of drugs to treat these diseases. The research will be published in the October edition of the journal, Nature Medicine.

Using mice, Dr Matthias Ernst at the Ludwig and Associate Professor Andy Giraud from the University of Melbourne (Western Hospital) found the clue when they made specific mutations to a molecule found on the surface of cells that is traditionally involved in helping regulate the body's immune system.

The receptor molecule called, gp130, acts as a molecular 'antenna', to transmit instructions to individual cells from soluble messenger molecules called cytokines found in the circulation and body fluids. This message service is what tells the cell how to respond to its environment.

Ernst and Giraud were surprised when the mice carrying mutations in gp130 developed cellular changes and other symptoms that mirrored those of gastric cancer and large bowel inflammation in humans.

Previous research in the USA and Japan has largely dismissed the regulatory role that gp130 plays in the protection of the digestive tract against stomach cancer and some forms of inflammatory bowel disease.

"Nobody suspected that interference with the messenger service engaged by gp130 could be linked with a 100 percent prevalence of early stages of gastric cancer in mice," says Giraud.

"Drug treatment is years away, but now that we have b

Contact: Jason Major
University of Melbourne

Page: 1 2 3

Related biology news :

1. Heart gene yields insights into evolution, disease risk
2. Two-month study of life in mid-Atlantic yields trove of species, new insights & questions
3. New survey reveals insights into unique relationship between mothers and pediatricians
4. Study yields insights into precancerous condition
5. Mutant mice lead to memory insights
6. Study of proteins offers insights into organization of biological networks
7. Common worm provides insights into salmonella virulence
8. Discovery in parasite movement may offer insights into malaria
9. New insights on sirtuins, involved in gene expression and aging
10. Rapidly evolving genes providing new insights in plant evolution
11. Yeast model yields insights into Parkinsons disease

Post Your Comments:
TAG: New insights into cause stomach cancer

(Date:10/2/2015)... DUBLIN , Oct. 02 2015 ... addition of the "Enforcing the Law Using ... http://www.researchandmarkets.com/research/6kp5mx/enforcing_the_law ) has announced the addition of ... report to their offering. --> Research ... addition of the "Enforcing the Law Using ...
(Date:9/30/2015)... global glucose monitoring device and diabetes management market is valued ... on the industry from Kalorama Information. Sales in the traditional glucose ... continuous glucose monitoring and sensor segment, according to the healthcare ... in its latest report, The Global Glucose Monitoring Market ... , ...
(Date:9/28/2015)...  The monitoring of vital signs, such as ... an essential component of patient assessment. Changes in ... a patient,s condition. However, in general care areas ... during routine observation rounds only once every four ... these observation rounds, the warning signs can go ...
Breaking Biology News(10 mins):
(Date:10/9/2015)... HERSHEY, Pa. and ROCKVILLE, ... Therapeutics, Inc. ("ITI"), a privately-held biotechnology company developing ... today announced that it has entered into an ... on LAMP-vax products for the treatment or prevention ... Upon execution of the agreement, Immunomic Therapeutics will ...
(Date:10/9/2015)... ... October 09, 2015 , ... Leading microbial genomics startup uBiome ... better understand the relationship between weight management and the microbiome. The study uses the ... participants using an iPhone app. , The uBiome app is available as a free ...
(Date:10/8/2015)... N.J. , Oct. 8, 2015  Genetic testing ... may aid the identification of more couples at risk ... a study presented today at the 2015 American Society ... October 10 in Baltimore, Maryland . ... Quest Diagnostics (NYSE: DGX ) are presenting at ...
(Date:10/8/2015)... , October 8, 2015 ... .   --> Goldman Small Cap ... the small cap and microcap sectors, announced today ... report on PharmaCyte Biotech, Inc. (OTCQB - PMCB), ... on developing and preparing treatments for cancer and ...
Breaking Biology Technology:
Cached News: