HOME >> BIOLOGY >> NEWS
New insights on sirtuins, involved in gene expression and aging

(PHILADELPHIA) -- In recent years, scientists have become interested in the workings of a family of enzymes called sirtuins, known to play critical roles in a variety of vital life processes, including metabolism, aging, and gene expression. Previous studies, for example, have suggested that low-calorie diets that extend life boost sirtuin activity dramatically, hinting at a link between metabolism and aging through sirtuins. Sirtuins also promote genomic stability, a process that goes awry in cancer and particularly as one ages.

Now, scientists at The Wistar Institute report new findings that further elucidate how sirtuins work and suggest how scientists might identify or design an activator to boost sirtuin activity using a structure-based approach. The research will be published Tuesday, May 18, in the Proceedings of the National Academy of Sciences.

"We know that the Sir2 sirtuin silences gene expression and stabilizes the genome in yeast," says Wistar professor Ronen Marmorstein, Ph.D., senior author of the study. "We also know that sirtuins are highly conserved in humans. The idea researchers are exploring is that if we could activate sirtuins, perhaps we could promote genomic stability and decrease cancer as well as other aging-related problems."

Marmorstein's research team has been focusing on the molecular details of how sirtuins work. Sirtuins are a family of enzymes, proteins that facilitate chemical reactions that involve converting a substrate to a product, forming intermediate substances along the way. Using a yeast sirtuin protein as a model, Marmorstein and his research team captured three-dimensional images of the sirtuin protein in association with a substrate and intermediate mimics, while in previous research his group determined the structure of the protein in association with product. Together, Marmorstein's work provides a comprehensive structural picture of enzymatic activity of sirtuins, an important step toward
'"/>

Contact: Franklin Hoke
hoke@wistar.upenn.edu
215-898-3716
The Wistar Institute
17-May-2004


Page: 1 2

Related biology news :

1. Heart gene yields insights into evolution, disease risk
2. Two-month study of life in mid-Atlantic yields trove of species, new insights & questions
3. New survey reveals insights into unique relationship between mothers and pediatricians
4. Study yields insights into precancerous condition
5. Mutant mice lead to memory insights
6. Study of proteins offers insights into organization of biological networks
7. Common worm provides insights into salmonella virulence
8. Discovery in parasite movement may offer insights into malaria
9. Rapidly evolving genes providing new insights in plant evolution
10. Yeast model yields insights into Parkinsons disease
11. Targeting transcription: New insights into turning genes on

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/14/2019)... ... , ... Join Jonathan Riek, PhD, VP, Musculoskeletal & Metabolic Imaging, BioTel ... 1pm EDT to learn about two common imaging methods in NAFLD/NASH to aid with ... common diffuse liver disease, with a worldwide prevalence of 20-46 percent. NAFLD can be ...
(Date:8/9/2019)... ... August 09, 2019 , ... With a demand in healthcare to lower unneeded ... visit urgent care centers (UCC) in the coming years, according to a new report ... for Urgent Care Centers , is a detailed look at the current state of ...
(Date:8/6/2019)... ... August 06, 2019 , ... The demand ... plant-based food in particular quickly entered the limelight – meat alternatives. Yet, to ... thermogelling and emulsifying ingredient such as methyl cellulose. This ingredient is highly synthetic. ...
Breaking Biology News(10 mins):
(Date:6/11/2019)... ... June 10, 2019 , ... ... add 80 of its scientific journals to DeepDyve’s rental service for peer-reviewed journals. ... continually expanding library of more than 20 million articles, sourced from more than ...
(Date:6/11/2019)... ... 2019 , ... Veterinary Regenerative Medicine company, VetStem Biopharma ... that their GMP facility for cell production is now approved by the California ... an important milestone for VetStem as it expands into contract cell manufacturing services. ...
(Date:6/6/2019)... ... 05, 2019 , ... WCCT Global, Inc ., a full-service early phase ... they will be receiving 3 awards at the 2019 CRO Leadership Awards, to be ... the categories of overall Quality and Compatibility (Access to desired markets, cultural fit, timely ...
(Date:5/31/2019)... ... May 29, 2019 , ... ... providing proprietary interest to our methodology, processes, and diagnostic techniques. The patent ... extends Somnology’s IP rights including our proprietary sleep scoring methodology. The approval ...
Breaking Biology Technology:
Cached News: