HOME >> BIOLOGY >> NEWS
New 'knockout' map helps study gene functions in model plant

Scientists have inactivated almost three-quarters of all genes in the genome of Arabidopsis thaliana, a species widely used in plant research. The feat, which results in the largest so-called "knockout" gene collection of a complex multi-cellular organism, now allows researchers to study the function of each of those genes individually or together.

The findings, published in the August 1 issue of the journal Science, mark an important milestone in the field of plant genomics. Following the release of the Arabidopsis genome sequence in 2000, the National Science Foundation (NSF) jump started the next phase of plant genome research, instituting the Arabidopsis 2010 Project to determine the location and function of each and every Arabidopsis gene by the year 2010. Knowing the function of all the genes in this model plant will aide scientists immensely in their work to improve disease resistance, control how quickly or slowly fruit will ripen, and create healthier and improved crops.

Joe Ecker at the Salk Institute for Biological Studies and his research team created knockouts, or inactivating mutations, in 21,700 of the estimated 29,454 Arabidopsis genes. Knocking out a gene or group of genes allows scientists to observe what goes wrong in the mutant plant and determine what function the inactivated gene(s) had in the plant system.

"This project provides a resource that is essential for understanding the function of genes mutants in which individual genes have been inactivated," says Parag Chitnis, program officer in the NSF's Division of Molecular and Cellular Biosciences. "Because the expression of hundreds of genes can change in a single condition, large complete collections of stable mutations are becoming an important tool for whole genome function and evolutionary biology," the report further emphasizes.

History was made in December of 2000 when the Arabidopsis research community released the complete sequence of
'"/>

Contact: Andrea Spiker
aspiker@nsf.gov
703-292-8070
National Science Foundation
31-Jul-2003


Page: 1 2 3

Related biology news :

1. Atacama rover helps NASA learn to search for life on Mars
2. Reducing allergens in the home helps inner-city children with asthma
3. As informatics grows, Indiana University helps set research agenda
4. New diagnostic technology helps justify earlier cataract surgery
5. New technique helps scientists reveal interactions between genes and drugs
6. Living at home helps young mothers stay in school
7. Hormone helps fish to mate, may affect human hearing
8. Harmless virus helps slow HIV by boosting immune proteins
9. Study helps explain island populations susceptibility to exotic diseases
10. Utah scientist helps discover new mouse species -- and maybe a new genus
11. Choice of food helps hungry caterpillar

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/2/2020)... ... July 01, 2020 , ... AltruBio Inc. http://www.altrubio.com , ... biologic for the treatment of steroid-refractory acute graft-versus-host disease (SR-aGVHD), at European Hematology ... Martin of the Fred Hutchinson Cancer Research Center, this single-arm, open-label Phase 1 ...
(Date:7/1/2020)... ... July 01, 2020 , ... Cure Glioblastoma, a registered ... common and aggressive adult brain cancer—announced today the appointments of its first Senior ... with supporting the organization’s initiatives and overall vision. , "Senior Fellows are more ...
(Date:6/25/2020)... ... June 24, 2020 , ... eClinical Solutions LLC , ... that accelerate drug development, is collaborating with Karyopharm Therapeutics (Nasdaq: KPTI ) ... with severe COVID-19. This is the first study of an XPO1 inhibitor in ...
Breaking Biology News(10 mins):
(Date:6/23/2020)... ... June 23, 2020 , ... Nobilis Therapeutics, ... that it has filed an Investigational New Drug application (IND) with the U.S. ... its lead drug candidate NBTX-001 in patients with panic disorder (PD). , "Adding ...
(Date:6/11/2020)... , ... June 09, 2020 , ... ... Phase I of a Small Business Innovation Research (SBIR) program funded by the ... Century: Rapid Toxin Detection in the Field”. The project’s goal was to engineer ...
(Date:6/3/2020)... ... June 03, 2020 , ... Thought Technology Ltd. is offering ... next installment, Dr. Inna Khazan will discuss the benefits of using mindfulness techniques ... to the feelings, thoughts, and emotions they are having in the present moment ...
(Date:5/30/2020)... ... May 29, 2020 , ... The Conference Forum is ... solely dedicated to the unique role of the Chief Medical Officer in the ... responsibilities, problem-solving, best practices and career development of CMOs and Heads of R&D ...
Breaking Biology Technology:
Cached News: