HOME >> BIOLOGY >> NEWS
New mechanism for display of foreign proteins to immune system

A new research study published in the August issue of Immunity reveals details about a poorly understood mechanism used to alert the immune system to the presence of virus infected cells and abnormal cells like cancer cells. The findings provide new insight into how the immune system identifies potentially harmful cells and may be exploited for future development of more effective vaccines.

It is well established that the immune system has sentinel cells whose job it is to report the presence of foreign invaders or cancers. In a process called crosspresentation, the sentinel cell internalizes foreign proteins, called antigens, from the environment and breaks them up into tiny fragments that are then displayed on the cell surface. Through this display the sentinel cell can then stimulate special immune cells called cytotoxic T lymphocytes to spring into action and battle the abnormal cells.

One of the ways that sentinel cells accomplish crosspresentation has been described in detail. Antigens are internalized into a specific compartment, transferred to the cytosol, chopped up by proteosomes, and then transported by the transporter associated with antigen processing (TAP) for display. However, there is some evidence that an alternative mechanism that does not involve TAP may also contribute to crosspresentation.

A research team led by Dr. Kenneth L. Rock from the Department of Pathology at the University of Massachusetts Medical School in Worcester examined the molecular mechanisms involved in the poorly understood TAP-independent crosspresentation pathway. By using chemical agents that differentially blocked one pathway and not the other, the TAP-independent pathway of presentation was shown to be distinct from the TAP-dependent pathway. This alternative pathway requires cysteine proteases and not proteosomes for chopping up proteins. The researchers went on to show that the cysteine protease Cat S plays a major role in generating presented pr
'"/>

Contact: Heidi Hardman
hhardman@cell.com
617-397-2879
Cell Press
17-Aug-2004


Page: 1 2

Related biology news :

1. Information system to help scientists analyze mechanisms of social behavior
2. Joslin researchers clarify mechanisms for beta-cell formation
3. Infants sighs may reset breathing regulation mechanism as well as help lungs develop
4. Researchers in UGA Vet School discover a mechanism that blocks replication of a retrovirus
5. New genetic mechanism for evolution
6. Protective mechanism exploited by tumors may provide new cancer treatment
7. New research suggests previously unrecognized mechanism by which blood vessels are patterned
8. UCSD biologists discover cells defense mechanism against class of disease-causing bacterial toxins
9. Biologists ID defense mechanism of leading fungal pathogen
10. UNC scientists uncover crucial mechanism for blood vessel development
11. Findings redefine mechanism of action of RNA helicase enzymes

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/13/2019)... ... June 13, 2019 , ... KICVentures announced today its plans ... Orthopedic and Pain Management-Driven ASC Conference in Chicago on Thursday, June 13th at 6:30 ... Dr. Chicago, IL in the 3rd floor Ticino Hospitality room in space #74T. , ...
(Date:6/11/2019)... ... 10, 2019 , ... Improved Pharma LLC announces the publication of “Predictive and ... The article was published online on April 29th, 2019. The authors are Stephen ... Chen of Purdue University. , The article is the most recent addition to a ...
(Date:6/6/2019)... ... June 05, 2019 , ... Ziegler, a ... advisor to Pathologists Bio-Medical Laboratories (PBM) on its recent acquisition by PathGroup. ... that provides services to more than one dozen hospitals and surgery centers in ...
Breaking Biology News(10 mins):
(Date:6/18/2019)... ... June 17, 2019 , ... ... entered into an agreement for production and manufacturing of GMP-grade adeno-associated virus (AAV) ... rhodopsin-mediated autosomal dominant retinitis pigmentosa (RHO-adRP) and IC-200 for the treatment of BEST1 ...
(Date:6/11/2019)... CITY, Calif. (PRWEB) , ... June 10, 2019 ... ... (IOPP) today announced IOPP will add 80 of its scientific journals to DeepDyve’s ... of physics-related content to DeepDyve’s continually expanding library of more than 20 million ...
(Date:5/31/2019)... ... May 29, 2019 , ... For many years, the primary forms ... cancer demand breakthrough therapies. Advances in immuno-oncology have led to the advent of Chimeric ... with engineered T cell receptors known as “CARs”. The CAR enables the final product ...
(Date:5/22/2019)... ... 22, 2019 , ... Artemis (formerly Agrilyst), the leading enterprise Cultivation ... round co-led by Astanor Ventures and Talis Capital with participation ... iSelect Fund . The company has raised $11.75m to date and will use the ...
Breaking Biology Technology:
Cached News: