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New mechanism for display of foreign proteins to immune system

oteins for the TAP-independent pathway of crosspresentation and contributes to immunity to viruses and transplanted tissues.

"We show unequivocally that this pathway is truly separate from the conventional TAP-dependent pathway. Having two distinct pathways involved in generating peptides, potentially in different amounts, could serve to increase the total number and diversity of peptides that are effectively presented and thereby broaden immune responses," says Dr. Rock. "This could also limit the ability of viruses to evade detection through their counter-surveillance mechanisms that block only one of these pathways."


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Contact: Heidi Hardman
hhardman@cell.com
617-397-2879
Cell Press
17-Aug-2004


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