HOME >> BIOLOGY >> NEWS
New milestones on the path to conquering HIV drug resistance (AIDS)

NEW BRUNSWICK/PISCATAWAY, N.J. HIV is a moving target, unpredictably changing direction to elude anti-AIDS drugs, but researchers at Rutgers are clearly on the track of solutions to combat HIV drug resistance. Leading a multidisciplinary ensemble of colleagues, Rutgers Chemistry Professor Eddy Arnold recently reported on studies that revealed how some drugs may be getting the better of the virus' molecular defenses.

Reports in the May issues of Nature Structural & Molecular Biology and the Journal of Medicinal Chemistry propose answers to why it is relatively difficult for the AIDS virus to develop resistance to the drug, tenofovir, or the DAPY (diarylpyrimidine) family of compounds, and offers explanations of the mechanisms involved.

Tenofovir and the DAPY compounds are different types of reverse transcriptase (RT) inhibitors. RT is the enzyme or molecular machine the AIDS virus uses to replicate its genetic material. The two life-saving drugs approach the problem of drug resistance in different ways.

Arnold and his colleagues work on drugs that target HIV RT. "We try to understand how these drugs work and how they may be able to evade resistance mechanisms so that we can apply the information to the design of better drugs," said Arnold, a resident faculty member of the Center for Advanced Biotechnology and Medicine. The research institute is jointly administered by the University of Medicine and Dentistry of New Jersey and Rutgers, The State University of New Jersey.

Since 1987, Arnold has collaborated with Stephen Hughes of the National Cancer Institute's Cancer Research and Development Center at Frederick, Md., constituting what Arnold calls "an inseparable team." Hughes is providing the biochemical analysis of the problem in conjunction with Arnold's X-ray crystallography a method by which X-ray diffraction patterns obtained from crystals are used to map the three-dimensional atomic structure of large molecules.

"W
'"/>

Contact: Joseph Blumberg
blumberg@ur.rutgers.edu
732-932-7084 x652
Rutgers, the State University of New Jersey
29-Jun-2004


Page: 1 2 3

Related biology news :

1. New reserach shows promise in conquering ulcer-causing H. pylori
2. Master of antimalarial resistance
3. Anthrax enzyme images reveal secrets of antibiotic resistance, suggest new drug design
4. Evolvability could be a driving force in drug resistance
5. Insecticide resistance: A constraint on evolutionary change
6. New drug shows promise against Gleevec resistance in mice
7. Study investigates breast cancer resistance to tamoxifen and possible way to reverse it
8. Antibiotic resistance risk from triclosan questioned
9. Cancer drug resistance research leads to possible therapeutic target for Alzheimers disease
10. Researchers string together players in pesticide resistance orchestra
11. Chicken litter harbors agents that generate antibiotic multi-resistance, according to UGA study

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New milestones the path conquering HIV drug resistance AIDS

(Date:10/29/2014)... have been blamed for increasing the risk of ... family history of schizophrenia, are widely accepted. Others, ... a parasite transmitted by soil, undercooked meat and ... A new study by Gary Smith, professor of ... Pennsylvania,s School of Veterinary Medicine, used epidemiological modeling ...
(Date:10/29/2014)... number of chemicals from household and industrial products are ... bodies. But for most of them, scientists have yet ... taken the first step toward doing that by estimating ... new method is published in the ACS journal ... and colleagues note that the risks to human health ...
(Date:10/29/2014)... on September 19, 2014, leading geneticist and humanitarian Prof. ... Sciences and Medicine at the University of Washington in ... Aviv University, was awarded the 2014 Lasker-Koshland Special Achievement ... honorary degree from TAU, Prof. King was the 2012-2013 ... for the past 18 years she has been the ...
Breaking Biology News(10 mins):Penn vet professor investigates parasite-schizophrenia connection 2Penn vet professor investigates parasite-schizophrenia connection 3Geneticist and humanitarian: Prof. Mary-Claire King receives Lasker Award 2
(Date:10/30/2014)... Ras Al Khaimah, UAE (PRWEB) October 30, 2014 ... the appointment of Dr. James A. Manganello, Chairman of the ... (NSCEC) of The Bahamas. The appointment was made by ... The Bahamas on September 24th, 2014. , More ... Cell Therapy and Research Bill , Prime Minister Perry Christie ...
(Date:10/30/2014)... in the development of quantum technologies has been proposed ... published today (28 October) in Nature Communications , ... a new type of flexibly designed microscopic trap for ... and specialised superfast computers, often depend on harnessing the ... these tiny particles are hugely problematic because of the ...
(Date:10/27/2014)... 27, 2014 The Italian ... exhibit and sell its artificial "lower limb", after ... patent.      (Photo: http://photos.prnewswire.com/prnh/20141027/713097 ... fighting, the definitive judgement has arrived: Roadrunnerfoot, the ... and accessible hi-tech prostheses with composite materials, has ...
(Date:10/27/2014)... MA (PRWEB) October 27, 2014 ... profit. SoundConnect , an industry leading unified ... its partners and agents to deliver cloud-based audio ... accelerate growth opportunities. , With SoundConnect’s Q4 ... every twenty-five video and/or web conferencing licenses sold, ...
Breaking Biology Technology:Grace Century’s Stem Cell Biobank Project Announces Chairman’s Appointment to National Stem Cell Ethics Committee of The Bahamas 2Grace Century’s Stem Cell Biobank Project Announces Chairman’s Appointment to National Stem Cell Ethics Committee of The Bahamas 3Italian Lower Limb Prosthesis Company Wins Lawsuit Against German Giant Ottobock 2SoundConnect Unveils Q4 Partner Incentives 2
Cached News: