HOME >> BIOLOGY >> NEWS
New model can aid in understanding immune system diseases

University of Iowa News Release EMBARGOED UNTIL 11 A.M. CT (US), TUESDAY, AUGUST 17, 2004 New Model Can Aid In Understanding Immune System Diseases Researchers trying to understand diseases and develop new treatments can't always depend on existing tools or organisms to make discoveries; sometimes they first must create models of the problems they want to study.

Such is the case with Epstein-Barr, a common virus that is often harmless but likely contributes to malignancies and autoimmnune disease in people with compromised immunity. A University of Iowa team has engineered a mouse that provides new insights into the virus.

The animal model has implications for advancing treatments for patients with AIDS or an organ transplant who get a certain type of cancer, and for people with immune system diseases such as lupus, arthritis and multiple sclerosis. The study results appear in the August issue of the journal Immunity.

The advance builds on previous UI studies done in cell culture and provides researchers with a model that allows them to see biological functions related to Epstein-Barr within the context of a whole organism, said Gail Bishop, Ph.D., Distinguished Professor of Microbiology and Internal Medicine in the UI Roy J. and Lucille A. Carver College of Medicine and a research career scientist with the Department of Veterans Affairs (VA) Iowa City Health Care System.

"Mice cannot be infected with Epstein-Barr because they do not have the receptor for this virus. What we have done is express in the mouse the most important transforming protein that is involved in the virus in humans," said Bishop, who also is associate director for basic science research at the Holden Comprehensive Cancer Center at the UI.

The Epstein-Barr virus, a member of the of herpes virus family, infects most people by adulthood, then remains latent (inactivated) after an initial and usually symptomless infection. People who get the
'"/>

Contact: Becky Soglin
becky-soglin@uiowa.edu
319-335-6660
University of Iowa
17-Aug-2004


Page: 1 2 3

Related biology news :

1. Molecular motor implicated in tissue remodeling
2. New fruitfly model of diabetes has future implications for pancreatic cell transplantation
3. Computer models expose humans as main cause of caribou decline
4. Physics gravity model applicable to disease spread
5. BioMed Central to consult funders and librarians over Open Access payment model
6. Study reveals surprising remodeling property of gene regulation process
7. Gene therapy reaches muscles throughout the body and reverses muscular dystrophy in animal model
8. Genetic model for devastating form of paraplegia suggests new treatments
9. New model explains why costly insect outbreaks hard to predict
10. A genetic model for hereditary spastic paraplegia (HSP) disease
11. New version of premier global climate model released

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/20/2017)... , July 20, 2017 Delta (NYSE: DAL ... board any Delta aircraft at Reagan Washington National Airport (DCA). ... Delta launches biometrics to ... Delta,s biometric ... Sky Club is now integrated into the boarding process to allow ...
(Date:6/23/2017)... and ITHACA, N.Y. , June ... Cornell University, a leader in dairy research, today announced ... designed to help reduce the chances that the global ... onset of this dairy project, Cornell University has become ... Sequencing the Food Supply Chain, a food safety initiative ...
(Date:5/23/2017)... first robotic gym for the rehabilitation and functional motor sense evaluation of ... Italy . The first 30 robots will be available from June ... . The technology was developed and patented at the IIT laboratories and ... thanks to a 10 million euro investment from entrepreneur Sergio Dompè. ... ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... October 11, 2017 , ... A new ... rates in frozen and fresh in vitro fertilization (IVF) transfer cycles. ... to IVF success. , After comparing the results from the fresh and frozen ...
(Date:10/10/2017)... ... October 10, 2017 , ... Dr. Bob Harman, founder ... local San Diego Rotary Club. The event entitled “Stem Cells and ... had 300+ attendees. Dr. Harman, DVM, MPVM was joined by two human doctors: ...
(Date:10/9/2017)... , Oct. 9, 2017  BioTech Holdings ... mechanism by which its ProCell stem cell therapy ... limb ischemia.  The Company, demonstrated that treatment with ... of limbs saved as compared to standard bone ... molecule HGF resulted in reduction of therapeutic effect.  ...
(Date:10/7/2017)... ... October 06, 2017 , ... With ... microscopy and surface analysis, Nanoscience Instruments is now expanding into Analytical Services. ... range of contract analysis services for advanced applications. Services will leverage techniques ...
Breaking Biology Technology:
Cached News: