HOME >> BIOLOGY >> NEWS
New molecular clues to herpes control

Chapel Hill - A study at the University of North Carolina at Chapel Hill may have identified a new way to halt herpes simplex virus in its molecular tracks. The findings, though still too basic for clinical use, shed new light on how this stubbornly persistent virus reproduces itself within nerve cells and may suggest possible ideas for designing therapies aimed at specific molecular targets.

"The picture that's emerging is that the virus, because it's an intracellular parasite, subverts normal regulatory cellular mechanisms in ways that optimize its own replication," said Dr. Steven L. Bachenheimer, professor of microbiology and immunology at UNC-CH School of Medicine.

Reporting in October's Journal of Virology, Bachenheimer and Tim I. McLean, a student in the curriculum of genetics and microbiology, note that a cellular protein kinase called JNK (pronounced 'junk'), seems important for herpes simplex virus type-1 (HSV1) to replicate. HSV1 is the highly transmissible herpes virus associated with painful cold sores.

"If we inhibit the activity of JNK, we see a reduction in viral yield in the cell," Bachenheimer said. In some cells the reduction was significant. Viral replication was down about 70%.

In laboratory tests on tissue cultures of primate and human cells, the UNC researchers demonstrated that JNK is activated three to four hours after the herpes virus infects the cell. The enzyme functions along a signaling pathway involved in responses to stress signaling.

They found that JNK activates a transcription factor - a protein that helps regulate the machinery that makes copies of DNA stored in the nucleus. These copies are blueprints that tell the cellular machinery which proteins to manufacture.

Because viruses ultimately depend on the host cell for reproduction, it seems likely that HSV1 would use its proteins to redirect pre-existing signaling pathways to promote its own replication.

"The virus is very clever in insinuating itse
'"/>

Contact: Karen Stinneford or Lynn Wooten
Lwooten@unch.unc.edu
919-966-3366
University of North Carolina School of Medicine
13-Oct-1999


Page: 1 2

Related biology news :

1. New molecular link key to cellular proteins involved in cancer progression, other diseases
2. Bacteria use molecular lasso to cop copper
3. UCLA molecular biologists uproot the tree of life
4. UCSD researchers are first to demonstrate molecular link between inflammation and cancer
5. Briggs takes to the molecular level Darwins findings on plants sensing the direction of light
6. Scientists identify molecular link driving spread of skin cancer
7. Study suggests first molecular target to halt spread of HPV
8. UNC scientists discover molecular pathway leading to nerve growth and regeneration
9. Innovative efforts target epigenetics, molecular imaging
10. Scientists discover molecular target for treatment of T cell acute lymphoblastic leukemia
11. Proteins transform DNA into molecular velcro

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/23/2020)... ... June 23, 2020 , ... In its June 22 online post, business and ... L. Sherley, M.D., Ph.D., founder and director of stem cell biotechnology company Asymmetrex ... 16 that starting July 5 it would begin offering free tissue stem ...
(Date:6/13/2020)... , ... June 11, 2020 , ... ... services, announces a significant expansion of its forensic genealogy team. Bode’s Forensic ... attorneys through proven forensic genealogy and DNA analysis methods. The team has added ...
(Date:6/5/2020)... ... 2020 , ... “Although we are disappointed to have to make this decision ... the public. We remain committed to creating a global platform to showcase the ... Sutcliffe, President of WMIS. , The abstract deadline for the virtual ...
Breaking Biology News(10 mins):
(Date:5/26/2020)... PARK, Calif. (PRWEB) , ... May 26, 2020 , ... ... , the most recognized brand of smart garage door openers, announce a new integration ... line of Wi-Fi enabled garage door openers powered by Aladdin Connect® can now be ...
(Date:5/21/2020)... CITY, Calif. (PRWEB) , ... May 20, 2020 ... ... announce the addition of Simon Prakash, who will serve as the company’s executive ... joins at a time when Exo is disrupting the medical imaging space, bringing ...
(Date:5/15/2020)... ... ... Sentien Biotechnologies, Inc., a clinical-stage biotechnology company developing novel approaches to cell therapy, ... continue to lead Sentien’s Board of Directors, a role he has filled for the ... management team. , Mr. Ganz has more than 30 years of experience ...
(Date:5/14/2020)... ... May 13, 2020 , ... Early ... readouts, providing little or no information on the drug’s mechanism of action (MOA). ... of compounds by measuring the activity of molecular pathways. This information can complement ...
Breaking Biology Technology:
Cached News: