HOME >> BIOLOGY >> NEWS
New prime-boost HIV vaccine strategy shows promise in monkeys

ter vaccination and then infected all the macaques with a high dose of SHIV. "Most other studies challenge after several weeks," says Dr. Moss, "but a vaccine that only protects for a short time is not very helpful. We extended the post-vaccination time to check long-term efficacy." Dr. Moss also stresses another important feature of their vaccine strategy: the monkeys were infected by applying the virus in the rectum. "The majority of HIV infections occur when the virus crosses mucous membranes, so we needed to see if our vaccine would work against this route of infection."

Although all 28 monkeys were infected, the vaccinated monkeys showed lower initial SHIV levels and quickly began to suppress the virus further. Twenty weeks after infection, the amount of virus in the bloodstream of the vaccinated monkeys was on average 2,000 times lower than controls. The researchers continue to monitor virus levels in these animals.

"These are among the very best outcomes we have seen in an animal model," says Peggy Johnston, Ph.D., NIAID's assistant director for HIV vaccines, "and we are using NIH's developmental resources and the HIV Vaccine Trials Network (HVTN) to move these and other promising vaccines into human trials in the United States and elsewhere as quickly as possible."

Both teams have already constructed HIV versions of the DNA and MVA vaccines, and human clinical trials are currently planned for the coming year. The rapid progress of these products and their future entry into clinical trials is being supported by NIAID through a range of programs put into place to fast-track HIV vaccines through the various stages of basic and preclinical research, product development and production, and clinical trials.


'"/>

Contact: Gregory Roa
greg.roa@nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
7-Mar-2001


Page: 1 2 3

Related biology news :

1. Cancer vaccine based on pathogenic listeria bacteria shows promise targeting metastases
2. Pneumococcal vaccine reduces ear infections, pneumonia, new study shows
3. UC Irvine scientists to develop vaccine to combat bioterrorism threat from deadly bacteria
4. First clinical study of new pediatric croup vaccine shows safety, tolerability in adults
5. Protective gene may enhance vaccine responses
6. Protein vaccine fully protects mice from lethal aerosol challenge with ricin toxin
7. New glycan arrays discover autoimmunogenic activities of SARS-CoV: concern over monkey vaccine
8. Growing new breed of vaccine-producing plants to fight human diseases worldwide
9. Childrens Hospital Boston receives more than $10 million to help make smallpox vaccine safer
10. Triple-vaccine strategy stimulates strong HIV-specific immune response in monkeys
11. Herpes tool allows researchers to customize Alzheimers vaccine

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/15/2017)... HAMPTON, Va. , Aug. 15 2017   ivWatch LLC ... effectiveness of intravenous (IV) therapy, today announced receipt of its ISO ... (QMS) developed by the International Organization for Standardization (ISO®). ... ivWatch Model 400 Continuous Monitoring device for ... "This ...
(Date:5/23/2017)... the first robotic gym for the rehabilitation and functional motor sense evaluation ... Genoa, Italy . The first 30 robots will be available from ... . The technology was developed and patented at the IIT laboratories ... Technology thanks to a 10 million euro investment from entrepreneur Sergio Dompè. ... ...
(Date:4/19/2017)... ALBANY, New York , April 19, 2017 /PRNewswire/ ... highly competitive, as its vendor landscape is marked by ... in the market is however held by five major ... and Safran. Together these companies accounted for nearly 61% ... majority of the leading companies in the global military ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... October 12, 2017 , ... ... of a United States multicenter, prospective clinical study that demonstrates the accuracy ... test capable of identifying clinically significant acute bacterial and viral respiratory tract ...
(Date:10/11/2017)... ... October 11, 2017 , ... At its national board ... Suneel I. Sheikh, the co-founder, CEO and chief research scientist of Minnesota-based Advanced ... for membership in ARCS Alumni Hall of Fame . ASTER Labs is ...
(Date:10/11/2017)... ... October 11, 2017 , ... Proscia Inc ... hosting a Webinar titled, “Pathology is going digital. Is your lab ready?” with ... adoption best practices and how Proscia improves lab economics and realizes an increase ...
(Date:10/11/2017)... , ... October 11, 2017 , ... ... the implantation and pregnancy rates in frozen and fresh in vitro fertilization ... progesterone and maternal age to IVF success. , After comparing the results from ...
Breaking Biology Technology:
Cached News: