HOME >> BIOLOGY >> NEWS
New prostate cancer gene identified

Phoenix, August 8th, 2004-Researchers at the Translational Genomics Research Institute (TGen) have found a new way to speed the discovery of genes that suppress tumors, and in the process identified a gene that appears to be important in prostate cancer. The findings appeared today in the journal Nature Genetics.

The gene, not previously known to be a tumor suppressor, most likely plays a role in regulating and maintaining normal tissue organization. The researchers have shown that the gene, known as EphB2, is inactivated in prostate cancer. This is the first time abnormalities in the gene have been linked to cancer. They believe loss of the gene's function leads to disorganization of cells and also encourages the growth and survival of prostate cancer cells.

"This finding provides critical insight into the factors that cause prostate cancer, which can be used for development of additional diagnostics and therapeutics for prostate cancer," said Dr. Spyro Mousses, head of TGen's Cancer Drug Development Laboratory and the paper's senior author. "Much additional research is warranted to determine the extent of its involvement in prostate cancer and other cancers as well."

"These findings represent a significant advancement in prostate cancer research, as the number of current treatment options for advanced prostate cancer remains limited," said Dr. John Carpten, Senior Investigator at TGen, Director of its Genetic Basis of Human Disease Division, and Head of the TGen Prostate Cancer Research Unit. "The discovery of mutations in this gene allows us the opportunity to explore a new path towards treating a significant number of men with advanced prostate cancer. As TGen's mission is to translate laboratory findings into the clinic, we hope to use this information to ultimately help provide prostate cancer patients more treatment options and a better quality of life."

The study was the result of an increasing trend in genome resea
'"/>

Contact: Candice Nulsen
cnulsen@tgen.org
The Translational Genomics Research Institute
8-Aug-2004


Page: 1 2

Related biology news :

1. Lycopene slows human prostate tumour growth in mice and combined with vitamin E is even better
2. Researchers identify distinctive signature for metastatic prostate cancer
3. Charting the future in prostate cancer care: A call to action
4. Study reveals first genetic step necessary for prostate cancer growth
5. Study narrows search for genes placing men at increased risk for prostate cancer
6. MICs shed light on prostate cancer
7. Alterations in vitamin D receptor gene increase prostate, breast cancer risk
8. U-M scientists find common virus in human prostate tissue
9. Newly designed nanoparticle quantum dots simultaneously target and image prostate tumors in mice
10. Gene expression patterns may help predict risk and progression of prostate cancer
11. Muscle-derived cells and gene therapy may cure for post-prostatectomy erectile dysfunction

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/1/2016)... 1, 2016  Today, the first day of American ... to develop a first of its kind workplace health ... Watson. In the first application of Watson ... IBM ), and Welltok will create a new offering ... cognitive analytics, delivered on Welltok,s health optimization platform. The ...
(Date:1/25/2016)... BLUE BELL, Pa. , Jan. 25, 2016   Unisys ... facial recognition system at John F. Kennedy (JFK) International Airport, ... and Border Protection (CBP) identify imposters attempting to enter ... or do not belong to them. pilot testing ... rolled out initially at three terminals at JFK during January 2016. ...
(Date:1/21/2016)... , January 21, 2016 ... to a new market research report "Emotion Detection and ... Others), Software Tools (Facial Expression, Voice Recognition and ... - Global forecast to 2020", published by MarketsandMarkets, ... expected to reach USD 22.65 Billion by 2020, ...
Breaking Biology News(10 mins):
(Date:2/3/2016)... , Feb. 3, 2016  Discovery Laboratories, ... focused on developing aerosolized KL4 surfactant therapies for ... Directors has approved an inducement award as a ... , its newly appointed President and Chief Executive ... Compensation Committee on February 1, 2016 and granted ...
(Date:2/3/2016)... 2016 New Jersey Health Foundation (NJHF) has ... for researchers in New Jersey ... demonstrates exciting potential.   James M. ... New Jersey Health Foundation Research Grant Program ... institutions— Princeton University, Rutgers University, Rowan University and ...
(Date:2/3/2016)... ... February 03, 2016 , ... Resilinc released online ... analyzes nearly 750 unique supply chain notifications and alerts generated by its ... chain risk management practitioners subscribe to the EventWatch service to receive early warnings ...
(Date:2/3/2016)... ... February 03, 2016 , ... Data Sciences ... solutions focused on social housing of small animal models in research studies. ... ² , DSI’s HD-S11 implant has evolved to allow researchers to simultaneously measure ...
Breaking Biology Technology:
Cached News: