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New prostate cancer gene identified

rch: a massive international collaboration of scientists from several institutions. Large-scale collaborative studies like this are increasingly common in complex disorders that have a huge impact on public health, such as cancer, heart disease, diabetes, and mental disorders.

"This work reveals a new mechanism by which cancer cells can evade normal tissue architecture, which is a hallmark of tumor development," says noted Johns Hopkins University and Howard Hughes researcher Dr. Bert Vogelstein. "While further research is needed to reveal the full impact of EphB2 on prostate cancer, every step helps when fighting this disease."

According to Mousses, complex diseases such as prostate cancer involve more than one gene - often many - and a host of environmental factors, which makes them particularly hard to investigate.

In addition to researchers at TGen, the study involved researchers from the University of Turku in Finland, the National Human Genome Research Institute in Bethesda, MD, Tampere University of Technology in Finland, the Jewish General Hospital in Montreal, Quebec, Canada, Johns Hopkins University School of Medicine in Baltimore, MD, the University of Basel in Switzerland, Tampere University Hospital in Finland, and Mount Sinai Hospital in Toronto, Ontario, Canada.

Prostate cancer is cancer of the gland that makes part of a man's seminal fluid. The prostate is located in front of the rectum and under the bladder. The disease usually progresses slowly and may not require treatment for many years, but prostate cancer was responsible for the deaths of almost 31,000 US men in 2001. It is the second-leading cause of cancer death in US men (after lung cancer.) The American Cancer Society estimates that more than 230,000 cases of prostate cancer will be diagnosed in US men in 2004; 98 percent of these men will live for at least five more years.


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Contact: Candice Nulsen
cnulsen@tgen.org
The Translational Genomics Research Institute
8-Aug-2004


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