HOME >> BIOLOGY >> NEWS
New protein separation technology

ANN ARBOR---If you think you finally understand the human genome and why it's important, get ready for proteomics. Discovering how cells respond to genetic instructions by creating millions of protein variations and figuring out what all those proteins do will be the next frontier of biomedical research.

The ability to identify cellular proteins will be especially valuable in cancer research, because each type of cancer produces its own protein biomarkers, according to Samir M. Hanash, M.D., Ph.D., a professor of pediatrics and communicable diseases in the University of Michigan Medical School. Unfortunately, current technology is neither accurate nor sensitive enough to detect most of these proteins, which often exist only in trace amounts.

A new liquid-phase protein separation technology under development at the U-M could help scientists solve the proteomics puzzle. The system eliminates the difficult, time-consuming 2-D gel electrophoresis method scientists now use to separate cells into individual proteins---the critical first step in proteomics analysis.

In the U-M system, proteins remain in a liquid phase throughout the separation process. According to David Lubman, Ph.D., a U-M professor of chemistry, liquid phase has many advantages over gels. "The process takes hours instead of days. It can handle large quantities of protein and detect trace amounts of protein," Lubman says. "It is easily interfaced for mass spectrometry detection, data are automatically digitized online and the entire process has the potential to be fully automated."

Hanash presented data from studies of the U-M protein separation method compared to traditional 2-D PAGE techniques on April 18 at the "Experimental Biology 2000" meeting in San Diego, Calif. Results also were published in the March 15 issue of Analytical Chemistry in an article by Hanash, Lubman, and others on their research team.

"Everyone d
'"/>

Contact: Sally Pobojewski
pobo@umich.edu
734-647-1844
University of Michigan
17-Apr-2000


Page: 1 2

Related biology news :

1. New molecular link key to cellular proteins involved in cancer progression, other diseases
2. Researchers identify protein promoting vascular tumor growth
3. UCI scientists successfully target key HIV protein; breakthrough may lead to new drug therapies
4. Experimental drug shown to block mutant protein causing blood disease
5. Loss of the neuronal adhesion protein d-catenin leads to severe cognitive dysfunction
6. Images of tail of protein needed for cell multiplication suggest anticancer drug targets
7. New dye directly reveals activated proteins in living cells
8. Disruption of protein-folding causes neurodegeneration, mental retardation
9. A new protein is discovered to play a key role in cancer progression
10. Optimizing proteins death domain halts leukemia in laboratory study
11. Stuck on you: Scientists lay bare secrets of bacterial attachment proteins

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/9/2016)... 2016 Elevay is currently known ... freedom for high net worth professionals seeking travel for ... connected world, there is still no substitute for a ... sealing your deal with a firm handshake. This is ... advantage of citizenship via investment programs like those offered ...
(Date:4/28/2016)... First quarter 2016:   , Revenues amounted ... quarter of 2015 The gross margin was 49% (27) ... the operating margin was 40% (-13) Earnings per share ... operations was SEK 249.9 M (21.2) , Outlook   ... M. The operating margin for 2016 is estimated to ...
(Date:4/19/2016)... , UAE, April 20, 2016 ... implemented as a compact web-based "all-in-one" system solution for ... biometric fingerprint reader or the door interface with integration ... modern access control systems. The minimal dimensions of the ... readers into the building installations offer considerable freedom of ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... Prairie, WI (PRWEB) , ... June 23, 2016 ... ... consultancy focused on quality, regulatory and technical consulting, provides a free webinar ... is presented on July 13, 2016 at 12pm CT at no charge. , ...
(Date:6/23/2016)... June 22, 2016  Amgen (NASDAQ: AMGN ... QB3@953 life sciences incubator to accelerate the ... shared laboratory space at QB3@953 was created to help ... obstacle for many early stage organizations - access to ... sponsorship, Amgen launched two "Amgen Golden Ticket" awards, providing ...
(Date:6/22/2016)... DIEGO , June 22, 2016 ... that will allow them to produce up to ... from one lot within one week. These high-quality, ... time laboriously preparing cells and spend more time ... possible through a proprietary, high-volume manufacturing process that ...
(Date:6/22/2016)...  According to Kalorama Information, the dominant trends ... include significant efforts in automation as well as ... affordable sequencers, say the healthcare market research firm, ... sample prep materials.  The healthcare market research company,s ... Next Generation Sequencing (NGS) , highlights major trends ...
Breaking Biology Technology:
Cached News: