HOME >> BIOLOGY >> NEWS
New protein separation technology

ANN ARBOR---If you think you finally understand the human genome and why it's important, get ready for proteomics. Discovering how cells respond to genetic instructions by creating millions of protein variations and figuring out what all those proteins do will be the next frontier of biomedical research.

The ability to identify cellular proteins will be especially valuable in cancer research, because each type of cancer produces its own protein biomarkers, according to Samir M. Hanash, M.D., Ph.D., a professor of pediatrics and communicable diseases in the University of Michigan Medical School. Unfortunately, current technology is neither accurate nor sensitive enough to detect most of these proteins, which often exist only in trace amounts.

A new liquid-phase protein separation technology under development at the U-M could help scientists solve the proteomics puzzle. The system eliminates the difficult, time-consuming 2-D gel electrophoresis method scientists now use to separate cells into individual proteins---the critical first step in proteomics analysis.

In the U-M system, proteins remain in a liquid phase throughout the separation process. According to David Lubman, Ph.D., a U-M professor of chemistry, liquid phase has many advantages over gels. "The process takes hours instead of days. It can handle large quantities of protein and detect trace amounts of protein," Lubman says. "It is easily interfaced for mass spectrometry detection, data are automatically digitized online and the entire process has the potential to be fully automated."

Hanash presented data from studies of the U-M protein separation method compared to traditional 2-D PAGE techniques on April 18 at the "Experimental Biology 2000" meeting in San Diego, Calif. Results also were published in the March 15 issue of Analytical Chemistry in an article by Hanash, Lubman, and others on their research team.

"Everyone d
'"/>

Contact: Sally Pobojewski
pobo@umich.edu
734-647-1844
University of Michigan
17-Apr-2000


Page: 1 2

Related biology news :

1. New molecular link key to cellular proteins involved in cancer progression, other diseases
2. Researchers identify protein promoting vascular tumor growth
3. UCI scientists successfully target key HIV protein; breakthrough may lead to new drug therapies
4. Experimental drug shown to block mutant protein causing blood disease
5. Loss of the neuronal adhesion protein d-catenin leads to severe cognitive dysfunction
6. Images of tail of protein needed for cell multiplication suggest anticancer drug targets
7. New dye directly reveals activated proteins in living cells
8. Disruption of protein-folding causes neurodegeneration, mental retardation
9. A new protein is discovered to play a key role in cancer progression
10. Optimizing proteins death domain halts leukemia in laboratory study
11. Stuck on you: Scientists lay bare secrets of bacterial attachment proteins

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New protein separation technology

(Date:8/28/2014)... PA, August 28, 2014 Dyslexia, the most ... is a neurological reading disability that occurs when ... language don,t function normally. , The use of ... brain activity is disrupted in dyslexia. However, most ... number of brain regions, leaving a gap in ...
(Date:8/28/2014)... of new roads will be built worldwide by 2050. ... wildernesses, where they bring an influx of destructive loggers, ... study has created a ,global roadmap, for prioritising road ... competing demands of development and environmental protection. , The ... that natural importance of ecosystems and a ,road-benefits, layer ...
(Date:8/28/2014)... . Cars, planes ... of sophisticated assembly lines. Mobile assembly carriers, on to which ... assembly lines. In the case of a car body, the ... a precise spatial and chronological sequence, resulting in a complete ... of such an assembly line at molecular level has been ...
Breaking Biology News(10 mins):Dyslexic readers have disrupted network connections in the brain 2Study shows where on the planet new roads should and should not go 2Study shows where on the planet new roads should and should not go 3Nanoscale assembly line 2Nanoscale assembly line 3
(Date:8/27/2014)... California (PRWEB) August 27, 2014 ... (LLNL), through Lawrence Livermore National Security LLC ... to develop and deliver a state-of-the-art laser system ... facility (ELI Beamlines), under construction in the Czech ... performance, the laser system, called the " High ...
(Date:8/27/2014)... , Aug. 27, 2014 Reportlinker.com ... available in its catalogue: Global Chelating ... About Chelating Agent A chelating ... covalent bonds with metal ions, thereby forming a ... some metal-ions have on chemical processes, formulations, and ...
(Date:8/27/2014)... 27, 2014 Guggenheim Securities, the investment banking ... the hiring of veteran equity analyst Charles "Tony" Butler ... Butler will focus on the biotech/biopharma sector. ... of experience and a broad network of relationships in ... Director and Head of Equities at Guggenheim Securities. "His ...
(Date:8/27/2014)... 2014  ARCH Venture Partners, one of the ... development of seed and early-stage advanced technology companies, ... with more than $400 million in subscriptions. ARCH ... target by more than $150 million. ... and potential of our approach to finding and ...
Breaking Biology Technology:LLNL Synchs up with ELI Beamlines on Timing System 2LLNL Synchs up with ELI Beamlines on Timing System 3Global Chelating Agents Market 2014-2018 2Global Chelating Agents Market 2014-2018 3Global Chelating Agents Market 2014-2018 4Guggenheim Securities Hires Analyst Charles "Tony" Butler to Expand Healthcare Coverage 2Latest ARCH Venture Partners Fund Closes Above $400 Million 2Latest ARCH Venture Partners Fund Closes Above $400 Million 3
Cached News: