HOME >> BIOLOGY >> NEWS
New proteomics tool offers a clear look at cellular proteins IDAT can detect proteins at an unprecedented resolution for research and clinical use

(Philadelphia PA) Scientists may have identified the genes in the human genome, but proteomics is the growing field of research that describes how proteins encoded in those genes work. Researchers at the University of Pennsylvania School of Medicine have created the first new technology for the proteomic era, a technique sensitive enough to detect individual proteins and robust enough to screen hundreds or thousands of molecules in mass automation.

The versatile technique, called IDAT, has a variety of potential uses from detecting cancer earlier to sifting through samples of molecules to find new candidates for drug research. In todays edition of Proceedings of the National Academy of Science, the researchers describe how they used IDAT to identify a protein marker for breast cancer at a resolution up to nine orders of magnitude more powerful than conventional techniques, and explain how the technique can be further refined.

"Nine orders of magnitude is a significant jump. If we were discussing computers, we would be talking about the differences between bytes and Gigabytes," said Mark I. Greene, MD, PhD, Professor in the Penn Department of Pathology and Laboratory Medicine. "IDAT has the potential to do for proteomics what PCR did for genomics in the last two decades."

IDAT works by snagging a target protein even in a vast mixture of separate molecules and broadcasting the presence of the targeted protein with a strong signal. IDAT stands for Immuno-Detection Amplified by T7 RNA polymerase and it combines the detecting ability of antibodies, highly specific immune system molecules, with the speed of a particular enzyme, T7 RNA polymerase, to act as an alarm system. The enzyme and the antibody both interact through another molecule called a promoter. When the antibody snags the targeted protein, it triggers the promoter that, in turn, triggers the enzyme into creating the signal. Researchers could then screen for the signal, actually a molecule
'"/>

Contact: Greg Lester
lesterg@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
22-Apr-2001


Page: 1 2 3

Related biology news :

1. 16 APS exercise research highlights, from reduced flu mortality to proteomics & obesity
2. New proteomics core at OHSU will speed discovery process
3. Michigan receives NCRR grant for tomorrows proteomics technology
4. PNNL wins record $10.2 million NIH grant for proteomics center
5. Purdue instrument to fashion custom-made proteomics chips
6. Fighting Mycobacterium tuberculosis with structural proteomics
7. NHLBI launches innovative proteomics centers
8. Collaboration to use proteomics to unravel mysteries of heart disease
9. Mass spectrometer weighs in as proteomics breakthrough
10. UB scientists report fast, simple method of generating designer RNA catalysts for proteomics
11. CF Foundation seizes proteomics for drug discovery

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/11/2017)... , April 11, 2017 NXT-ID, ... security technology company, announces the appointment of independent Directors Mr. ... to its Board of Directors, furthering the company,s corporate ... ... NXT-ID, we look forward to their guidance and benefiting from ...
(Date:4/4/2017)... NEW YORK , April 4, 2017   ... solutions, today announced that the United States Patent and ... The patent broadly covers the linking of an iris ... the same transaction) and represents the company,s 45 th ... our latest patent is very timely given the multi-modal ...
(Date:3/29/2017)... , March 29, 2017  higi, the health IT ... North America , today announced a ... the acquisition of EveryMove. The new investment and acquisition ... of tools to transform population health activities through the ... data. higi collects and secures data today ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... ... October 10, 2017 , ... ... program has won a US2020 STEM Mentoring Award. Representatives of the FirstHand program ... in Volunteer Experience from US2020. , US2020’s mission is to change the trajectory ...
(Date:10/10/2017)... ... October 10, 2017 , ... USDM Life Sciences , ... life sciences and healthcare industries, announces a presentation by Subbu Viswanathan and Jennifer ... “Automating GxP Validation for Agile Cloud Platforms,” will present a revolutionary approach to ...
(Date:10/9/2017)... ... ... At its national board meeting in North Carolina, ARCS® Foundation President ... and Astronomy, has been selected for membership in ARCS Alumni Hall of Fame ... Prize in Fundamental physics for the discovery of the accelerating expansion of the universe, ...
(Date:10/7/2017)... ... October 06, 2017 , ... ... Hi-C metagenome deconvolution product, featuring the first commercially available Hi-C kit. Researchers ... perform Hi-C metagenome deconvolution using their own facilities, supplementing the company’s full-service ...
Breaking Biology Technology:
Cached News: