HOME >> BIOLOGY >> NEWS
New proteomics tool offers a clear look at cellular proteins IDAT can detect proteins at an unprecedented resolution for research and clinical use

(Philadelphia PA) Scientists may have identified the genes in the human genome, but proteomics is the growing field of research that describes how proteins encoded in those genes work. Researchers at the University of Pennsylvania School of Medicine have created the first new technology for the proteomic era, a technique sensitive enough to detect individual proteins and robust enough to screen hundreds or thousands of molecules in mass automation.

The versatile technique, called IDAT, has a variety of potential uses from detecting cancer earlier to sifting through samples of molecules to find new candidates for drug research. In todays edition of Proceedings of the National Academy of Science, the researchers describe how they used IDAT to identify a protein marker for breast cancer at a resolution up to nine orders of magnitude more powerful than conventional techniques, and explain how the technique can be further refined.

"Nine orders of magnitude is a significant jump. If we were discussing computers, we would be talking about the differences between bytes and Gigabytes," said Mark I. Greene, MD, PhD, Professor in the Penn Department of Pathology and Laboratory Medicine. "IDAT has the potential to do for proteomics what PCR did for genomics in the last two decades."

IDAT works by snagging a target protein even in a vast mixture of separate molecules and broadcasting the presence of the targeted protein with a strong signal. IDAT stands for Immuno-Detection Amplified by T7 RNA polymerase and it combines the detecting ability of antibodies, highly specific immune system molecules, with the speed of a particular enzyme, T7 RNA polymerase, to act as an alarm system. The enzyme and the antibody both interact through another molecule called a promoter. When the antibody snags the targeted protein, it triggers the promoter that, in turn, triggers the enzyme into creating the signal. Researchers could then screen for the signal, actually a molecule
'"/>

Contact: Greg Lester
lesterg@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
22-Apr-2001


Page: 1 2 3

Related biology news :

1. 16 APS exercise research highlights, from reduced flu mortality to proteomics & obesity
2. New proteomics core at OHSU will speed discovery process
3. Michigan receives NCRR grant for tomorrows proteomics technology
4. PNNL wins record $10.2 million NIH grant for proteomics center
5. Purdue instrument to fashion custom-made proteomics chips
6. Fighting Mycobacterium tuberculosis with structural proteomics
7. NHLBI launches innovative proteomics centers
8. Collaboration to use proteomics to unravel mysteries of heart disease
9. Mass spectrometer weighs in as proteomics breakthrough
10. UB scientists report fast, simple method of generating designer RNA catalysts for proteomics
11. CF Foundation seizes proteomics for drug discovery

Post Your Comments:
(Date:7/2/2015)... 2015 Research and ... the "Natural Language Processing Market by Type ... Pattern & Image Recognition) - Worldwide Forecast to ... The key vendors occupying the market are 3M, ... Corporation, NetBase Solutions, SAS Institute Inc., Verint Systems ...
(Date:7/2/2015)... Research and Markets( http://www.researchandmarkets.com/research/jvft55/next_generation ) has ... Market by Application, Technology, Function & Geography - Global ... The next generation biometrics market is expected to ... 17.9% between 2015 and 2020 Travel & ... Safran SA ( France ), NEC ...
(Date:7/2/2015)... GOTHENBURG, Sweden , July 2, 2015 ... fingerprint sensors FPC1025, FPC1035, FPC1145 and FPC1155 from the distributor ... is one of FPC,s distributors in Asia ... Q4 2015. The sensors will be used by smartphone manufacturers ... 268 MSEK is included in the communicated revenue guidance of ...
Breaking Biology News(10 mins):Natural Language Processing Market by Type (Rule-Based, Statistical, and Hybrid), Technologies (Recognition, IVR, OCR, Pattern & Image Recognition) - Worldwide Forecast to 2020 2Next Generation Biometrics Market 2015 - Global Forecast to 2020 with Safran, NEC, 3M Cogent, Fujitsu & Suprema Dominating the $24 Billion Market 2Next Generation Biometrics Market 2015 - Global Forecast to 2020 with Safran, NEC, 3M Cogent, Fujitsu & Suprema Dominating the $24 Billion Market 3FPC Receives Order for Touch Fingerprint Sensors of 268 MSEK 2
(Date:7/7/2015)... , ... July 07, 2015 , ... ... 2020 from $107.56 million in 2015, growing at a CAGR of 17.89% between ... aptamers, RNA-based aptamers, and XNA-based aptamers. Based on applications, the report is segmented ...
(Date:7/7/2015)... ... July 07, 2015 , ... Since its inception in ... What began as a conference for European Statistical Programmers, has evolved in the ... biometrical area. Statistical Programmers, Data Managers and Biostatisticians all over the world, share, ...
(Date:7/7/2015)... (PRWEB) , ... July 07, 2015 , ... CSM, a ... team as Vice President of Finance. Morse has an extensive background in financial management ... to the CSM team. In his new role, Morse will oversee all financial areas ...
(Date:7/7/2015)... ... July 07, 2015 , ... Currently ... system was developed to solve many of the complex logistical and data ... that involve multiple clinical sites and/or remote data coordination centers. , CentrePoint ...
Breaking Biology Technology:Aptamers Market Growing at 17.89% CAGR to 2020 – New Research Available at RnRMarketResearch.com 2Aptamers Market Growing at 17.89% CAGR to 2020 – New Research Available at RnRMarketResearch.com 3Aptamers Market Growing at 17.89% CAGR to 2020 – New Research Available at RnRMarketResearch.com 4Aptamers Market Growing at 17.89% CAGR to 2020 – New Research Available at RnRMarketResearch.com 5PhUSE Delighted to Welcome Member Number 5.000 2CSM Appoints Michael Morse as Vice President of Finance 2ActiGraph Launches CentrePoint Cloud-based Study Management Software Platform 2ActiGraph Launches CentrePoint Cloud-based Study Management Software Platform 3
Cached News: