The aim of this study was to find out whether EHDA could be used to generate corticosteroid aerosols in a size range between one and five micrometers with a low geometric standard deviation (GSD) and in quantities sufficiently high to make administration to patients feasible.
The authors of the study, Electro-Hydrodynamic Atomization of Drug Solutions for Inhalation Purposes, are Jeroen C. Ijsebaert, Kees B. Geerse, and Jan C. M. Marijnissen from the Particle Technology Group, DelftChemTech, Faculty of Applied Sciences, Delft University of Technology, Delft, The Netherlands; and Jan-Willem J. Lammers and Pieter Zanen from the Department of Pulmonary Diseases, University Hospital Utrecht, Utrecht, The Netherlands. Their findings appeared in the December 2001 edition of the Journal of Applied Physiology.
The energy source for EHDA is an electric field. A liquid is supplied to a nozzle, and an electric field is generated between the nozzle and a counterelectrode. When the electrical stress overcomes the surface tension of the liquid, a cone is formed, from which a thin jet emerges. The jet breaks up into monodisperse droplets.
The device spray section in the experiment used a nozzle-ring configuration. The nozzle and the ring were connected to two high-voltage power supplies, which yield the necessary electric field. The ring "focuses" the spray to prevent immediate heavy loss of the charged aerosol. The corona discharge is generated from a grounded sharp needle, placed perpendicular below the nozzle. The distance between the needle and the nozzle can be varied. While they are transported to the exit of the system by a filtered airflow (high-efficiency par
Contact: Donna Krupa
American Physiological Society