New research on investigational Alzheimer's disease treatment suggests significant improvement of symptoms

Reminyl's Dual Mode of Action Provides Novel Approach for Treatment

7 April 2000, Stockholm -- Results from a new five-month study conducted by Janssen Research Foundation show that patients who were treated with Reminyl® (galantamine), a new treatment for Alzheimer's disease showed a significant improvement in their cognitive, functional and behavioural symptoms, when measured by commonly-used assessments of the severity of Alzheimer's disease. The study is being presented today for the first time at the International Stockholm/Springfield Symposium, a meeting of leading experts to discuss advances in Alzheimer's therapy.

After 5 months, patients who were treated with 16 mg/day and 24 mg/day of Reminyl had significantly better scores on all efficacy measures compared to placebo (p<0.001 for both doses). "For the first time, we are able to show that Reminyl has benefits not only on cognition, but on patients' ability to function, while also postponing the emergence of behavioural symptoms," commented Pierre Tariot, MD, a Reminyl investigator and professor of psychiatry, medicine and neurology at the University of Rochester Medical Center, New York. "Even the most basic improvement of symptoms, such as being able to prepare a meal on their own or remembering the events of the day, can provide relief for patients and often their caregivers."

Efficacy was measured using a variety of subscales including the Alzheimer's Disease Assessment Scale (ADAS-cog), which measures a patient's memory, language, orientation and other aspects of cognition; the Clinician's Interview-Based Impression of Change plus Caregiver Input (CIBIC-plus), which provides a global assessment of behaviour, general psychiatric symptoms, cognition and activities of daily living; the 23-item version of the Alzheimer's Disease Cooperative Study Inventory (ADCS-ADL), which also measures activities of daily living; and the NeuroPsychiatric Invent

Contact: Roseann Ward/Louise Strong

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