HOME >> BIOLOGY >> NEWS
New role of genes in breast cancer

An Australian twin study has uncovered that high breast density, the strongest known risk factor for breast cancer, is genetically linked.

"The hunt is now on to find the genes responsible for breast density," says Professor John Hopper, Director of the University of Melbourne's Centre for Genetic Epidemiology, which houses the Australian Twin Registry.

"Once found, the genes may help define new sub-types of breast cancer, and enable targeted prevention strategies and treatment. It might also explain a greater amount of the genetic effect on breast cancer than do the recently discovered genes BRCA1 and BRCA2," he says.

Australian breast cancer researchers, in collaboration with Canadian colleagues, published the study results in the latest edition of New England Journal of Medicine. The study involved 607 twin pairs from Melbourne, Sydney and Perth, recruited through the Australian Twin Registry, and 355 North American twin pairs.

The research found that in both the Australian and North American twins, genetically-identical twin pairs had similar breast densities. Non-identical pairs, who share half their genes, had breast densities about half as similar.

Breast density is determined by the amount of connective and epithelial tissue - which appears light on a mammogram - compared with amount of fat tissue - which appears dark. It is not related to firmness and cannot be felt in the breast. It is only detectable by having a mammogram.

Women with breast density in the top 20 percent have a five-fold increased risk of breast cancer than women in the bottom 20 percent for their age.

"Although there is evidence that age and some lifestyle factors, such as having children, can change breast density, there is still a large spread in the distribution of breast density across women of the same age," says Hopper.

"This results show that genetic factors play the major role in explaining why women of the sam
'"/>

Contact: Jason Major
jmajor@unimelb.edu.au
61-383-440-181
University of Melbourne
19-Sep-2002


Page: 1 2

Related biology news :

1. Belgian researchers explore revolutionary approach to angiogenesis
2. Tracing genes, biologists show lizard migration is traced to Florida
3. Certain genes boost fish oils protection against breast cancer
4. Fossil genes reveal how life sheds form and function
5. Missing genes may help explain why plague bacteria are so deadly
6. Do genes respond to global warming?
7. Genetic map of important tree genes outlined
8. Mitochondrial genes cause nuclear mischief
9. Identifying tick genes could halt disease, bioterrorism threat
10. A genetic disorder yields insight into genes and cognition
11. Mouse study shows NPAS3 and NPAS1 genes may be linked to psychosis

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/27/2018)... Calif. (PRWEB) , ... November 27, 2018 , ... ... Sons. The companies have worked together to integrate the LabArchives Classroom Edition ... The combined offering will be available beginning January of 2019. ...
(Date:11/23/2018)... ... 23, 2018 , ... uBiome, the leader in microbial genomics, ... Oppenheimer Center for Neurobiology of Stress and Resilience, to its Medical Advisory Board. ... Mayer will bring to uBiome his expertise on the connections between the digestive ...
(Date:11/20/2018)... NEW YORK (PRWEB) , ... November 19, 2018 ... ... Report by Applications (academic research tools, drug development, agriculture, human clinical therapeutics, ... and plant breeding products), by Technology (drug compound and target screening, and agriculture ...
Breaking Biology News(10 mins):
(Date:11/20/2018)... SPRINGS, Ga. (PRWEB) , ... November 19, 2018 , ... ... now receive custom dental implants from Dr. Dan Myers at THE DENTIST ... offering dental implant placement and restorations for the last 20 years. He now offers ...
(Date:11/13/2018)... ... November 12, 2018 , ... AseptiScope(TM), Inc. announces ... large U.S. studies, published last week, confirm pose a significant health risk. ... (AJIC) conclude that stethoscopes are often improperly or rarely disinfected. In the AJIC ...
(Date:11/11/2018)... ... 09, 2018 , ... Triple W, an innovator of connected health devices, today ... for DFree ®, the first health tech wearable device for incontinence that monitors ... the bathroom. The announcement was made during CES Unveiled New York, an invite-only tech ...
(Date:11/7/2018)... Mass. (PRWEB) , ... November 07, 2018 , ... ... system for algae at AzCATI, the Arizona Center for Algae Technology and Innovation at ... facilitate process development and trials for those involved with algal and predator control applications. ...
Breaking Biology Technology:
Cached News: