New role of genes in breast cancer

An Australian twin study has uncovered that high breast density, the strongest known risk factor for breast cancer, is genetically linked.

"The hunt is now on to find the genes responsible for breast density," says Professor John Hopper, Director of the University of Melbourne's Centre for Genetic Epidemiology, which houses the Australian Twin Registry.

"Once found, the genes may help define new sub-types of breast cancer, and enable targeted prevention strategies and treatment. It might also explain a greater amount of the genetic effect on breast cancer than do the recently discovered genes BRCA1 and BRCA2," he says.

Australian breast cancer researchers, in collaboration with Canadian colleagues, published the study results in the latest edition of New England Journal of Medicine. The study involved 607 twin pairs from Melbourne, Sydney and Perth, recruited through the Australian Twin Registry, and 355 North American twin pairs.

The research found that in both the Australian and North American twins, genetically-identical twin pairs had similar breast densities. Non-identical pairs, who share half their genes, had breast densities about half as similar.

Breast density is determined by the amount of connective and epithelial tissue - which appears light on a mammogram - compared with amount of fat tissue - which appears dark. It is not related to firmness and cannot be felt in the breast. It is only detectable by having a mammogram.

Women with breast density in the top 20 percent have a five-fold increased risk of breast cancer than women in the bottom 20 percent for their age.

"Although there is evidence that age and some lifestyle factors, such as having children, can change breast density, there is still a large spread in the distribution of breast density across women of the same age," says Hopper.

"This results show that genetic factors play the major role in explaining why women of the sam

Contact: Jason Major
University of Melbourne

Page: 1 2

Related biology news :

1. Belgian researchers explore revolutionary approach to angiogenesis
2. Tracing genes, biologists show lizard migration is traced to Florida
3. Certain genes boost fish oils protection against breast cancer
4. Fossil genes reveal how life sheds form and function
5. Missing genes may help explain why plague bacteria are so deadly
6. Do genes respond to global warming?
7. Genetic map of important tree genes outlined
8. Mitochondrial genes cause nuclear mischief
9. Identifying tick genes could halt disease, bioterrorism threat
10. A genetic disorder yields insight into genes and cognition
11. Mouse study shows NPAS3 and NPAS1 genes may be linked to psychosis

Post Your Comments:

(Date:10/5/2018)... ... October 04, 2018 , ... High dose of biotin may cause ... such as cardiac troponin has serious clinical complications. There is an increasing trend of ... still unknown. , High dose of biotin supplement use may continue to increase ...
(Date:10/3/2018)... ... October 03, 2018 , ... ... commercialization of first-in-class stromal cell immunotherapies, announced that ORBCEL-M™, a second generation ... diabetes and progressive diabetic kidney disease in a four-site, pan-European Phase I/II ...
(Date:10/2/2018)... ... October 02, 2018 , ... Through this webinar, sponsored by ... They will also learn the role of calcium kinetics in cardiac safety testing. The ... officer at PPSC Biography; and Tsang Wai Lam, an assay development scientist at PPSC. ...
Breaking Biology News(10 mins):
(Date:10/11/2018)... ... October 11, 2018 , ... ... and software solutions, in collaboration with HP, the global leader in printing, has ... GHS Chemical Labels on all HP PageWide Printers. , The award-winning Avery UltraDuty ...
(Date:10/5/2018)... ... 2018 , ... Earthres Group, Inc., a multi-disciplinary engineering firm, ... identity and better reflects its current breadth of markets and services. Marketing now ... related support services to clients in seven market sectors, and currently operates in ...
(Date:10/2/2018)... (PRWEB) , ... October 02, 2018 , ... ... or ignored, contamination endangers the reliability and reproducibility of experimental data. Each lab ... , In this educational webinar, which is sponsored by Eppendorf , attendees ...
(Date:9/28/2018)... ... September 28, 2018 , ... ... tech innovators, engineers, and scientists from around the world, is excited to announce ... of San Marcos, as the winner of the LabRoots Summer 2018 Textbook Scholarship, ...
Breaking Biology Technology:
Cached News: