New role of genes in breast cancer

An Australian twin study has uncovered that high breast density, the strongest known risk factor for breast cancer, is genetically linked.

"The hunt is now on to find the genes responsible for breast density," says Professor John Hopper, Director of the University of Melbourne's Centre for Genetic Epidemiology, which houses the Australian Twin Registry.

"Once found, the genes may help define new sub-types of breast cancer, and enable targeted prevention strategies and treatment. It might also explain a greater amount of the genetic effect on breast cancer than do the recently discovered genes BRCA1 and BRCA2," he says.

Australian breast cancer researchers, in collaboration with Canadian colleagues, published the study results in the latest edition of New England Journal of Medicine. The study involved 607 twin pairs from Melbourne, Sydney and Perth, recruited through the Australian Twin Registry, and 355 North American twin pairs.

The research found that in both the Australian and North American twins, genetically-identical twin pairs had similar breast densities. Non-identical pairs, who share half their genes, had breast densities about half as similar.

Breast density is determined by the amount of connective and epithelial tissue - which appears light on a mammogram - compared with amount of fat tissue - which appears dark. It is not related to firmness and cannot be felt in the breast. It is only detectable by having a mammogram.

Women with breast density in the top 20 percent have a five-fold increased risk of breast cancer than women in the bottom 20 percent for their age.

"Although there is evidence that age and some lifestyle factors, such as having children, can change breast density, there is still a large spread in the distribution of breast density across women of the same age," says Hopper.

"This results show that genetic factors play the major role in explaining why women of the sam

Contact: Jason Major
University of Melbourne

Page: 1 2

Related biology news :

1. Belgian researchers explore revolutionary approach to angiogenesis
2. Tracing genes, biologists show lizard migration is traced to Florida
3. Certain genes boost fish oils protection against breast cancer
4. Fossil genes reveal how life sheds form and function
5. Missing genes may help explain why plague bacteria are so deadly
6. Do genes respond to global warming?
7. Genetic map of important tree genes outlined
8. Mitochondrial genes cause nuclear mischief
9. Identifying tick genes could halt disease, bioterrorism threat
10. A genetic disorder yields insight into genes and cognition
11. Mouse study shows NPAS3 and NPAS1 genes may be linked to psychosis

Post Your Comments:

(Date:1/20/2019)... ... 16, 2019 , ... uBiome, the leader in microbial genomics, ... artificial intelligence (AI) and a data-centric approach to decentralize medicine using blockchain to ... People will Crohn’s or other chronic medical conditions join a relevant study through ...
(Date:1/14/2019)... SUNNYVALE, Calif. (PRWEB) , ... January 14, 2019 ... ... a proprietary technology to detect precancer and cancer cells in blood, will present ... revealing significant advancement in the fight against colorectal cancer. The results from this ...
(Date:1/10/2019)... N.J. (PRWEB) , ... January 10, 2019 , ... ... to improve the translational gap between inexpensive in vitro studies and significantly more ... prediction of in vivo efficacy and toxicity. To address this need, researchers have ...
Breaking Biology News(10 mins):
(Date:1/28/2019)... ... January 28, 2019 , ... Fragment-based ... weight compounds. In this early stage, false positives can be problematic due to ... is vital that screening techniques are highly sensitive to detect weak interactions. ...
(Date:1/21/2019)... ... January 21, 2019 , ... Microbial Discovery ... for the industrial and institutional cleaning market. MDG’s SporActiv liquid and powder product ... needs. Applications include odor control, floor and tile cleaners, carpets, drains, portable restroom ...
(Date:1/20/2019)... ... January 17, 2019 , ... TrakCel, the leading ... The Quick Life Science Group (Quick Healthcare and QuickSTAT) today announce a partnership ... global cell and gene therapy industry to track products and manage the logistical ...
(Date:1/10/2019)... ... ... a local shelter when he was around two years old. According to his mom, ... was adopted, he tore his right cruciate ligament. Though he had his ACL surgically ... injury. , Sure enough, when Rascal was about nine years old, he began showing symptoms ...
Breaking Biology Technology:
Cached News: