HOME >> BIOLOGY >> NEWS
New roles for protein modifications in cell migration

In every stage of development, cells are directed to make their way through the body to contribute to the building of or take up residence in new tissues and organs. The guidance of cell migration is achieved by signals intrinsic to the cell or from its surrounding environment. In work published on December 21 in the online edition of Nature Cell Biology, the RIKEN Center for Developmental Biology (CDB) Laboratory for Cell Migration, under team leader Kiyoji Nishiwaki, has demonstrated the role of a protein modification known as glycosylation in guiding the migration of gonadal cells in the nematode, C. elegans.

This study, conducted in collaboration with researchers from the Japanese National Institute of Advanced Industrial Science and Technology, and the Universities of Nagoya (Japan) and Toronto (Canada), is the first to reveal the function of glycosylation in the action of an ADAM-family protease, a finding of potential significance to the study and treatment of human autoimmune diseases and other disorders that involve defects in ADAM-family protein function.

Interactions between the basement membrane of the migrating gonad and that of the body wall are one of the keystone processes of gonadal development. The C. elegans gonad is U-shaped, the result of the directed migration of cells known as distal tip cells present at the leading ends of the developing gonad in larvae. The gene mig-17, which Nishiwaki previously showed to be essential to this guided movement, is expressed in muscle cells and secreted into the body cavity where it binds to the migrating gonadal tip cells. Distal tip cells in worms engineered to lack the MIG -17 protein fail to steer cell migration properly, resulting in abnormal development and a emeanderingf gonad phenotype. However, the means by which MIG-17 coordinates the timing and direction of the developing gonadfs progress though the larval body has remained unknown.

MIG-17 is an ADAM (a disintegrin and meta
'"/>

Contact: Doug Sipp
sipp@cdb.riken.jp
RIKEN Center for Developmental Biology
25-Dec-2003


Page: 1 2 3

Related biology news :

1. UT Southwestern scientists prove certain proteins play unexpected roles in genetic transcription
2. New molecular link key to cellular proteins involved in cancer progression, other diseases
3. Researchers identify protein promoting vascular tumor growth
4. UCI scientists successfully target key HIV protein; breakthrough may lead to new drug therapies
5. Experimental drug shown to block mutant protein causing blood disease
6. Loss of the neuronal adhesion protein d-catenin leads to severe cognitive dysfunction
7. Images of tail of protein needed for cell multiplication suggest anticancer drug targets
8. New dye directly reveals activated proteins in living cells
9. Disruption of protein-folding causes neurodegeneration, mental retardation
10. A new protein is discovered to play a key role in cancer progression
11. Optimizing proteins death domain halts leukemia in laboratory study

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/8/2017)... , Feb. 7, 2017 Report Highlights ... by 2021 from $8.3 billion in 2016 at a ... to 2021. Report Includes - An overview of ... market trends, with data from 2015 and 2016, and ... - Segmentation of the market on the basis of ...
(Date:2/3/2017)... ANTONIO , Feb. 3, 2017  Texas Biomedical Research ... Dr. Larry Schlesinger as the Institute,s new ... Texas Biomed effective May 31, 2017. He is currently the ... Director of the Center for Microbial Interface Biology at Ohio ... Schlesinger as the new President and CEO of Texas Biomed," ...
(Date:2/1/2017)... , February 1, 2017 IDTechEx Research, ... on emerging technology, announces the availability of a new report, ... Continue Reading ... ... industrial and collaborative robots. Source: IDTechEx Report "Sensors for Robotics: Technologies, ...
Breaking Biology News(10 mins):
(Date:2/22/2017)... ... February 22, 2017 , ... ... (TOPEC), the leading medical education provider of women’s health, primary care, and ... Accreditation Council for Continuing Medical Education (ACCME). ACCME’s Accreditation with Commendation is ...
(Date:2/22/2017)... ... February 22, 2017 , ... LabRoots , the ... from around the world, is pleased to announce the launch of a new scholarship ... mathematics (STEM) fields. , This merit-based scholarship is open to all high school seniors, ...
(Date:2/22/2017)... SAN DIEGO , Feb. 22, 2017 ... reported the results of a study that validated the ... pathogens that are associated with increased mortality in immune-suppressed ... transplant patients. The objective of the ... capture of Cytomegalovirus (CMV), Epstein-Barr virus (EBV) and Herpes ...
(Date:2/22/2017)... SAN DIEGO , Feb. 22, ... (OTCQB:CELZ) announced today expansion of its translational research ... product through establishment of laboratory facilities in San ... the San Diego BioLabs facility, a biotechnology incubator ... and Sanofi. In November 2016, the ...
Breaking Biology Technology:
Cached News: