HOME >> BIOLOGY >> NEWS
New roles for protein modifications in cell migration

In every stage of development, cells are directed to make their way through the body to contribute to the building of or take up residence in new tissues and organs. The guidance of cell migration is achieved by signals intrinsic to the cell or from its surrounding environment. In work published on December 21 in the online edition of Nature Cell Biology, the RIKEN Center for Developmental Biology (CDB) Laboratory for Cell Migration, under team leader Kiyoji Nishiwaki, has demonstrated the role of a protein modification known as glycosylation in guiding the migration of gonadal cells in the nematode, C. elegans.

This study, conducted in collaboration with researchers from the Japanese National Institute of Advanced Industrial Science and Technology, and the Universities of Nagoya (Japan) and Toronto (Canada), is the first to reveal the function of glycosylation in the action of an ADAM-family protease, a finding of potential significance to the study and treatment of human autoimmune diseases and other disorders that involve defects in ADAM-family protein function.

Interactions between the basement membrane of the migrating gonad and that of the body wall are one of the keystone processes of gonadal development. The C. elegans gonad is U-shaped, the result of the directed migration of cells known as distal tip cells present at the leading ends of the developing gonad in larvae. The gene mig-17, which Nishiwaki previously showed to be essential to this guided movement, is expressed in muscle cells and secreted into the body cavity where it binds to the migrating gonadal tip cells. Distal tip cells in worms engineered to lack the MIG -17 protein fail to steer cell migration properly, resulting in abnormal development and a emeanderingf gonad phenotype. However, the means by which MIG-17 coordinates the timing and direction of the developing gonadfs progress though the larval body has remained unknown.

MIG-17 is an ADAM (a disintegrin and meta
'"/>

Contact: Doug Sipp
sipp@cdb.riken.jp
RIKEN Center for Developmental Biology
25-Dec-2003


Page: 1 2 3

Related biology news :

1. UT Southwestern scientists prove certain proteins play unexpected roles in genetic transcription
2. New molecular link key to cellular proteins involved in cancer progression, other diseases
3. Researchers identify protein promoting vascular tumor growth
4. UCI scientists successfully target key HIV protein; breakthrough may lead to new drug therapies
5. Experimental drug shown to block mutant protein causing blood disease
6. Loss of the neuronal adhesion protein d-catenin leads to severe cognitive dysfunction
7. Images of tail of protein needed for cell multiplication suggest anticancer drug targets
8. New dye directly reveals activated proteins in living cells
9. Disruption of protein-folding causes neurodegeneration, mental retardation
10. A new protein is discovered to play a key role in cancer progression
11. Optimizing proteins death domain halts leukemia in laboratory study

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New roles for protein modifications cell migration

(Date:10/15/2014)... spreading rapidly and to an unexpected extent. The outbreak ... and the virus shows a new disease dynamic in ... this reason, the German National Academy of Sciences Leopoldina, ... and the Union of the German Academies of Sciences ... epidemic today. , In the statement the academies call ...
(Date:10/15/2014)... NXT-ID, Inc. (NASDAQ: NXTD and NXTDW) ... growing mobile commerce market releases photos and video of the recent ... October 13 th . Gino Pereira , ... angel investor Mr. Chad A. Verdi rang the bell.  ... his investors and employees "for their work and dedication in bringing ...
(Date:10/15/2014)... 15, 2014   Neurotechnology , a provider ... availability of the VeriLook Surveillance 3.0 software ... real-time biometric face identification using live video streams ... The new version not only identifies faces in ... objects while they are moving through the video ...
Breaking Biology News(10 mins):Academies call for consequences from the Ebola virus epidemic 2Academies call for consequences from the Ebola virus epidemic 3Academies call for consequences from the Ebola virus epidemic 4Academies call for consequences from the Ebola virus epidemic 5Photo Release: NXT-ID Inc. Rings Opening Bell of the NASDAQ Stock Market October 13th 2Photo Release: NXT-ID Inc. Rings Opening Bell of the NASDAQ Stock Market October 13th 3VeriLook Surveillance 3.0 SDK Identifies Faces and Moving Objects, Differentiates Pedestrians from Other Moving Objects in Video Surveillance Systems 2VeriLook Surveillance 3.0 SDK Identifies Faces and Moving Objects, Differentiates Pedestrians from Other Moving Objects in Video Surveillance Systems 3
(Date:10/22/2014)... and BOSTON , Oct. 22, 2014 ... leading global specialty pharmaceutical company, and Rhythm, a biopharmaceutical ... exclusive option to acquire Rhythm,s wholly owned subsidiary, Rhythm ... ghrelin agonist, for the treatment of diabetic gastroparesis and ... completed a successful Phase 2 trial of relamorelin for ...
(Date:10/22/2014)... (PRWEB) October 21, 2014 The North ... concerned market North America with analysis and forecast of ... 2013, and is expected to reach $623.6 million by ... 2018. , Browse through the TOC of the North ... of the in-depth analysis provided. This also provides a ...
(Date:10/22/2014)... October 22, 2014 Involution Studios ... release of a new infographic, Understanding Ebola . ... a beautifully designed, easy to follow informative tool for ... of outbreak, symptoms and prevention. , "As the news ... the 2014 Ebola outbreak represents not only a healthcare ...
(Date:10/22/2014)... (PRWEB) October 22, 2014 Currently ... Sartorius, A & D Weighing, Rice Lake, and ... Semi-Micro Balance . The Sartorius CPA Semi-Micro Balance ... affordable high-quality, precise, and user-friendly laboratory balance. , ... laboratory equipment, their laboratory balances are well known ...
Breaking Biology Technology:Actavis Signs Option to Acquire Rhythm Subsidiary and its GI Development Product, Relamorelin 2Actavis Signs Option to Acquire Rhythm Subsidiary and its GI Development Product, Relamorelin 3Actavis Signs Option to Acquire Rhythm Subsidiary and its GI Development Product, Relamorelin 4Actavis Signs Option to Acquire Rhythm Subsidiary and its GI Development Product, Relamorelin 5The North American crystal oscillator market is expected to reach $623.6 million by 2018 - New Report by MicroMarket Monitor 2The North American crystal oscillator market is expected to reach $623.6 million by 2018 - New Report by MicroMarket Monitor 3The North American crystal oscillator market is expected to reach $623.6 million by 2018 - New Report by MicroMarket Monitor 4Involution Studios' Ebola Infographic Provides Key Disease Information and Statistics at a Glance 2Pipette.com Launches the Addition of Sartorius CPA Semi-Micro Balance to Their Product Portfolio with Special Promotional Pricing 2Pipette.com Launches the Addition of Sartorius CPA Semi-Micro Balance to Their Product Portfolio with Special Promotional Pricing 3
Cached News: