HOME >> BIOLOGY >> NEWS
New roles for protein modifications in cell migration

lloprotease) protease, a family of secreted or membrane proteins first identified as components of various snake venoms, where they have hemorrhagic and anti-coagulatory effects. ADAM-family proteases have been implicated in a number of human physiological and pathological processes, including blood coagulation disorders, rheumatoid arthritis and asthma. These proteins act to proteolytically release membrane-bound growth factors or to disrupt components of extracellular matrices such as collagen and proteoglycans (which help to build skin and soft tissue), and their roles in development and differentiation are the focus of interest in many research labs.

Nishiwakifs team analyzed a number of mutations that result in aberrant gonadal phenotypes similar to those seen in mig-17 mutants, including the mutation of the gene that encodes MIG-23. This protein was found to be structurally related to nucleoside diphosphatases (NDPases), glycosylating proteins found in the Golgi apparatus, the intracellular processing center where proteins are modified, sorted and released from the cell. Glycosylation involves the addition of a sugar to a site on a protein chain, a post-translational modification whose roles are incompletely understood, but which is thought to serve a regulatory function in some signaling molecules. On further investigation, MIG-23 mutants showed reductions in NDPase activity. The wild-type MIG-23 protein successfully rescued yeast mutants for NDPase, lending solid support to the case for the NDPase nature of MIG-23.

The similarity between the MIG-23 and MIG-17 phenotypes suggested that the mutation of MIG-23 might result in abnormal MIG-17 glycosylation. Using gel electrophoresis, Nishiwaki and colleagues demonstrated that MIG-17 molecules in MIG-23 mutants had lower than normal molecular weights consistent with the loss of glycosylation, while immunoblotting studies confirmed that in these mutants MIG-17 failed to bind sugars at the normal l
'"/>

Contact: Doug Sipp
sipp@cdb.riken.jp
RIKEN Center for Developmental Biology
25-Dec-2003


Page: 1 2 3

Related biology news :

1. UT Southwestern scientists prove certain proteins play unexpected roles in genetic transcription
2. New molecular link key to cellular proteins involved in cancer progression, other diseases
3. Researchers identify protein promoting vascular tumor growth
4. UCI scientists successfully target key HIV protein; breakthrough may lead to new drug therapies
5. Experimental drug shown to block mutant protein causing blood disease
6. Loss of the neuronal adhesion protein d-catenin leads to severe cognitive dysfunction
7. Images of tail of protein needed for cell multiplication suggest anticancer drug targets
8. New dye directly reveals activated proteins in living cells
9. Disruption of protein-folding causes neurodegeneration, mental retardation
10. A new protein is discovered to play a key role in cancer progression
11. Optimizing proteins death domain halts leukemia in laboratory study

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New roles for protein modifications cell migration

(Date:7/20/2015)... -- Acuity Market Intelligence,s latest research "The Global Biometrics ... Privacy" forecasts that between 2014 and 2020 nearly ... to smart mobile devices by 2.2 billion mobile ... to generate more than $67.9 billion in total ...    "Biometrics is at the center ...
(Date:7/9/2015)... July 9, 2015  Unchained Labs just can,t ... acquisition of Avid Nano. Avid Nano designs, develops ... systems.    Also today, Unchained Labs ... easiest to use protein sizing system. The pUNk ... protein,s hydrodynamic size, size distribution, aggregation population and ...
(Date:7/8/2015)... The consumer products industry for innovative ... products such as wearables, smart wallets & other smart technology ... devices continues to rapidly grow.  Biometrics & Wearable Device Companies ... Google Inc. (NASDAQ: GOOG ), Apple Inc. (NASDAQ: ... (NASDAQ: GPRO ) and Baidu Inc. (NASDAQ: BIDU ...
Breaking Biology News(10 mins):Biometrics on Smart Mobile Devices to Redefine Digital Identity with 12.9 Billion Biometric App Downloads between 2014 and 2020 2Unchained Labs just can't get enough, acquires Avid Nano, rocks out the new pUNk! 2Consumers Flock to This Summer's Must Have Tech Gadgets as Latest Digital Wallets, Smart Technology & Wearable Products Continue to Grow in Popularity & Functionality 2Consumers Flock to This Summer's Must Have Tech Gadgets as Latest Digital Wallets, Smart Technology & Wearable Products Continue to Grow in Popularity & Functionality 3Consumers Flock to This Summer's Must Have Tech Gadgets as Latest Digital Wallets, Smart Technology & Wearable Products Continue to Grow in Popularity & Functionality 4Consumers Flock to This Summer's Must Have Tech Gadgets as Latest Digital Wallets, Smart Technology & Wearable Products Continue to Grow in Popularity & Functionality 5Consumers Flock to This Summer's Must Have Tech Gadgets as Latest Digital Wallets, Smart Technology & Wearable Products Continue to Grow in Popularity & Functionality 6
(Date:7/24/2015)... , July 24, 2015  Champions Oncology (OTC-BB: ... technology solutions and services to personalize the development and ... its financial and operational results for the fourth quarter ... Tuesday, July 28, 2015, before market open. ... the results that day at 9:00 a.m. EDT (6:00 ...
(Date:7/24/2015)... 24, 2015 , Adds integrated ... Expands product offering for chronic kidney disease and oncology ... diabetes-related complications and dermatology , Increases group revenue ... or ,the Company"), a leading China ... marketing biopharmaceutical products, today announced that it has acquired ...
(Date:7/23/2015)... ... July 23, 2015 , ... Science and technology continue to improve all ... and devices – according to Susan Chang, MD, director of the Division of Neuro-oncology ... and new technology are impacting the development of new treatments and advancing strategies to ...
(Date:7/23/2015)... (PRWEB) , ... July 23, 2015 , ... The Pittcon ... the Harry S. Mosher Professor of Chemistry and Professor, by courtesy, of Applied Physics ... Optical Single-Molecule Detection in Solids Led to Super-Resolution Nanoscopy in Cells and Beyond” , ...
Breaking Biology Technology:Champions Oncology to Announce Fourth Quarter Financial Results on Tuesday, July 28 23SBio Acquires Zhejiang Wansheng Pharmaceutical 23SBio Acquires Zhejiang Wansheng Pharmaceutical 33SBio Acquires Zhejiang Wansheng Pharmaceutical 4Experts Present How Science and New Technology are Driving New Brain Tumor Treatments and Improving Quality of Life 2Experts Present How Science and New Technology are Driving New Brain Tumor Treatments and Improving Quality of Life 3The 2014 Nobel Prize in Chemistry Recipient W. E. Moerner, to Deliver Wallace H. Coulter Lecture at Pittcon 2016 2The 2014 Nobel Prize in Chemistry Recipient W. E. Moerner, to Deliver Wallace H. Coulter Lecture at Pittcon 2016 3
Cached News: