HOME >> BIOLOGY >> NEWS
New sequence involved in DNA replication timing may aid in cancer detection

Bethesda, MD - Scientists have discovered a DNA sequence that is involved in controlling the timing of DNA replication. Because alterations in DNA replication timing are associated with cancer, this discovery may lead to improved methods for cancer detection.

The research appears as the "Paper of the Week" in the October 1 issue of the Journal of Biological Chemistry, an American Society for Biochemistry and Molecular Biology journal.

Before a cell can divide, it must duplicate its DNA. Duplication, which occurs during the S phase of the cell cycle, is initiated at many replication origins in the DNA molecule. These replication origins fire at specific times throughout S phase, causing each segment of the genome to replicate at a precise time.

"S phase lasts about 8 hours in human cells and about 40 minutes in cells of the fission yeast, Schizosaccharomyces pombe," explained Joel A. Huberman of Roswell Park Cancer Institute. "In both cases, some portions of DNA molecules are nearly always duplicated early in S phase while other portions are nearly always duplicated late."

Until recently, very little was known about how cells control replication timing. Studies in budding yeast (Saccharomyces cerevisiae) have suggested that, by default, replication origins fire early in S phase, but they can be forced to fire later by flanking and internal DNA sequences. Now, Huberman and Chulee Yompakdee have discovered a stretch of DNA that verifies this hypothesis.

To study DNA replication timing, Huberman and Yompakdee used fission yeast as a model organism because of its small size, rapid cell cycle, and convenient genetics. "Human beings have 46 large chromosomes, while cells of the tiny fission yeast contain three much smaller chromosomes," noted Huberman. "Despite these differences, the process of DNA replication is very similar in humans and fission yeast."

The scientists found that the DNA surrounding m
'"/>

Contact: Nicole Kresge
nkresge@asbmb.org
301-634-7415
American Society for Biochemistry and Molecular Biology
24-Sep-2004


Page: 1 2

Related biology news :

1. Scientists sequence genome of kind of organism central to biospheres carbon cycle
2. Human chromosome 5 final sequence analysis released to public
3. Microarrays, key genome expression trackers, work better when probes are sequence-verified
4. New research outlines public health consequences
5. Genetic sequence identified for anti-bacterial sea slug protein
6. Gene-rich human Chromosome 19 sequence completed
7. Scientists crack genome sequence of a major parasitic pathogen
8. UN study shows environmental consequences from ongoing boom in personal computer sales
9. Announcement of the chicken genome sequence and genome variation maps
10. Ecosystem consequences of a single, genetically based plant trait
11. U of Minnesota receives NSF grant to sequence bacterial genome

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/14/2019)... ... August 13, 2019 , ... Join Anguraj Sadanandam, ... Institute of Cancer Research (ICR) in a live webinar on Wednesday, ... of biomarker and companion diagnostic development including machine learning approaches in different gastrointestinal ...
(Date:8/9/2019)... ARLINGTON, Va. (PRWEB) , ... August 09, 2019 , ... ... options for patients, more and more patients will visit urgent care centers (UCC) in ... firm Kalorama Information. The report, The Market for Urgent Care Centers , is ...
(Date:8/6/2019)... ... August 06, 2019 , ... VetStem ... clinical, regulatory and GMP manufacturing experience. In November it spun out a ... extensive regulatory experience and one of the first cGMP cell manufacturing facilities ...
Breaking Biology News(10 mins):
(Date:8/14/2019)... Pa. (PRWEB) , ... August 13, 2019 , ... ... nuclear receptor and in vitro toxicology testing solutions, announced the appointment of Mark ... industry experience to the Board. , Mark McLoughlin will lend his healthcare expertise ...
(Date:8/7/2019)... ... ... Locus Agricultural Solutions (Locus AG) reports record levels of carbon sequestered in ... ® , which is pulling up to 121% more carbon into the soil than ... from the treatment of almonds, cherries, turf/sod, grapes and citrus across the U.S., as ...
(Date:8/6/2019)... DEERFIELD, Ill. (PRWEB) , ... August 05, 2019 ... ... announced that Jason Casarella has been recognized as a distinguished leader by PharmaVOICE ... is featured in an article in the magazine’s July/August special issue. , As ...
(Date:7/30/2019)... , ... July 30, 2019 , ... ... premiere team building and cooking events company. Not only has the company already ... also started offering Private Cooking Parties to its guests. , With Lajollacooks4u’s Private ...
Breaking Biology Technology:
Cached News: