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New sequence involved in DNA replication timing may aid in cancer detection

any late-firing origins contains repeats of a 10-basepair sequence that is rich in the nucleic acid component, guanine. Yompakdee and Huberman named these repeats "Late Consensus Sequences" (LCS). They found that one copy of an LCS produced no detectable effect on replication timing, two copies produced a partial effect, and three copies caused replication to occur in late S phase. The researchers confirmed this finding by removing the LCSs from a late-replicating origin to convert it to an early-replicating origin.

"Interestingly," noted Huberman, "in many cancer cells, the normal order of DNA replication is altered: regions that should replicate late sometimes replicate early and vice versa." As a result, tests for DNA replication timing may eventually become a method for the early detection of cancer.

"Replication timing assays are one of many promising techniques that are currently being studied that may, in the future, allow much earlier cancer detection than is possible today," concluded Huberman.


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Contact: Nicole Kresge
nkresge@asbmb.org
301-634-7415
American Society for Biochemistry and Molecular Biology
24-Sep-2004


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