HOME >> BIOLOGY >> NEWS
New signaling pathway found, may be linked to movement disorders

St. Louis, July 11, 2002 Though previous evidence points to the contrary, scientists have discovered that the protein known as fibroblast growth factor 14 (FGF14) may not actually behave like a growth factor. The research suggests that FGF14 is instead involved in transmitting signals from one nerve cell to another and may help regulate walking and other movements. The protein could, therefore, be linked to movement disorders such as Parkinson's and Huntington's diseases.

"We believe we have found a new signaling pathway in the brain," says study leader David M. Ornitz, M.D., Ph.D., professor of molecular biology and pharmacology at Washington University School of Medicine in St. Louis. "Once we learn what FGF14 does at the molecular level, I believe we may uncover a new mechanism for regulating nerve cell function."

The work is published in the July 3 issue of the journal Neuron. It is the first study to examine the role of FGF14 in living animals and could provide new targets for testing future drugs designed to treat movement disorders and seizures, says Ornitz, who also leads the cancer and developmental biology program at the Alvin J. Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine.

Ornitz and the team of investigators developed a strain of mice lacking the gene for FGF14. They expected these mice to have brain abnormalities and to perhaps die before birth. To their surprise, however, the mice seemed physically healthy and lived relatively normal lives, though most were about 15 percent under-weight after two weeks of age.

But the young mice did develop coordination problems and abnormal posture. Compared with normal mice, the genetically altered animals walked sluggishly and shuffled, and they had reduced muscle strength. They also were less sensitive to stimulants such as cocaine and amphetamines and were more prone to drug-induced seizures. The investigators also examined t
'"/>

Contact: Darrell E. Ward
wardd@msnotes.wustl.edu
314-286-0122
Washington University School of Medicine
11-Jul-2002


Page: 1 2

Related biology news :

1. Activated signaling pathway may predict lung cancer patients response to gefitinib
2. NRH1 and Wnt signaling come together in convergent extension
3. From lung to gut the Wnt signaling pathway transforms cell fate
4. Equine clonings triple play sheds light on calcium, cell signaling, human disease
5. UT Southwestern researchers learn importance of insulin family signaling in male sex determination
6. Mantis shrimp fluoresce to enhance signaling in the dim ocean depths
7. OHSU researchers discover molecular signaling system controlling aspects of embryonic development
8. New study identifies gene signaling puberty
9. Are the bright colors of some avian eggs signaling female genetic quality to their mates?
10. Scientists map signaling molecule crucial to survival, disease
11. Researchers identify molecular signaling system that is crucial for plant fertility

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/28/2020)... ... May 28, 2020 , ... DuPont ... liquefaction: AMYLEX® 6T. The innovative enzyme enables numerous business gains for breweries ... locally-sourced raw materials, improve productivity, maximize yield, ensure consistent quality and ultimately ...
(Date:5/21/2020)... ... May 19, 2020 , ... ... operations management solutions, today introduced BioMed to their award-winning computerized maintenance management ... connecting the people and systems around biomedical engineering to better allocate staff ...
(Date:5/14/2020)... N.J. (PRWEB) , ... May ... ... SIMPLY – a platform that helps Life Science Manufacturers accurately and easily ... LAUNCH," automating the development of Gross-to-Net models by projecting discounts/rebates to Commercial ...
Breaking Biology News(10 mins):
(Date:5/15/2020)... (PRWEB) , ... May 15, 2020 , ... Sentien Biotechnologies, ... appointment of Richard Ganz as Executive Chairman. Mr. Ganz will continue to lead ... as well as work closely with CEO Brian Miller and Sentien’s management team. ...
(Date:5/14/2020)... ... May 12, 2020 , ... ... translational research, is bringing together thousands of industry leaders, clinicians, research scientists, medical ... two plenary speakers, Carl June, MD, Director of the Center for Cellular Immunotherapies ...
(Date:5/14/2020)... ... May 13, 2020 , ... Early stages of ... little or no information on the drug’s mechanism of action (MOA). Gene expression ... by measuring the activity of molecular pathways. This information can complement phenotypic readouts ...
(Date:5/5/2020)... ... May 04, 2020 , ... ... the life sciences industry, today announced that Informa Training Partners, a life sciences ... name to Red Nucleus Boston, effective immediately. , “The name change solidifies a ...
Breaking Biology Technology:
Cached News: