HOME >> BIOLOGY >> NEWS
New software streamlines the search for disease-causing genes

One of the greatest challenges in molecular medicine is identifying the genes that cause specific diseases often a painstaking process requiring months of laboratory trial and error. Now researchers have designed a computer program with the potential for dramatically speeding up the search for disease-causing genes and hastening the discovery of new drugs to treat a wide range of genetic illnesses.

The new software called Digital Disease is described in a study in the June 8 issue of the journal Science.

"The beauty of our software is that it runs in under a second on a computer instead of taking months to years in a lab," says Jonathan Usuka, a graduate student in chemistry and co-author of the Science study.

Usuka developed Digital Disease in collaboration with colleagues at the Roche pharmaceutical company, where he has been working as a part-time consultant while completing his doctoral dissertation.

Of mice and men

"The idea behind Digital Disease is shockingly simple," Usuka says. The software scans databases containing computerized maps of DNA molecules, then instantly locates irregularities in genes that might be responsible for cancer, diabetes and other ailments. Instead of searching through maps of the human genome, Digital Disease scans the DNA of mice, which are genetically similar to people.

"Human genes and mouse genes are about 80 percent identical," Usuka points out, "so if you can identify a genetic mutation in mice, you can easily locate the same mutation in humans."

Genes are located on chromosomes, which are actually molecules of DNA. Each gene, in turn, is made up of thousands of chemical subunits called nucleotides strung together in a specific sequence.

Every nucleotide contains one of four chemicals known by the abbreviations A, T, C and G. The order in which the four nucleotides occur determines how a gene functions and its ultimate effect on the physical makeup of both people and mice - everything f
'"/>

Contact: Mark Shwartz
mshwartz@stanford.edu
650-723-9296
Stanford University
6-Jun-2001


Page: 1 2 3 4

Related biology news :

1. U of T microbiologists achieve results with pattern recognition software
2. New software developed at Rensselaer predicts promising ingredients for new drugs
3. Genetic testing, computer risk-assessment software prove effective in predicting breast cancer
4. Virginia Bioinformatics Institute and Phenomenome Discoveries developing software to allow visualization of genes and proteins
5. DNA gene chips and novel software used to describe kidney development
6. Officials design Web-based software for managing hazardous chemicals
7. New research software to simulate biochemical processes
8. Genome scientists muster computer software tools for handling the flood of raw data from the Human Genome Project and related efforts
9. MTU researchers develop new software to help clean up contamination sites
10. Screening technique streamlines search for anticancer drugs
11. Leader in cancer treatment and prevention research honored

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/17/2016)... -- AIC announces that it has just released a new white paper authored by Zettar ... high speed data transfer storage solutions. Photo - http://photos.prnewswire.com/prnh/20161116/440463 ... ... ... Setting up a high performance computing or HPC system can be ...
(Date:11/15/2016)... , Nov. 15, 2016  Synthetic Biologics, ... developing therapeutics focused on the gut microbiome, today ... of 25,000,000 shares of its common stock and ... stock at a price to the public of ... to Synthetic Biologics from the offering, excluding the ...
(Date:11/14/2016)... Nov. 14, 2016  xG Technology, Inc. ("xG" or ... critical wireless communications for use in challenging operating environments, ... 30, 2016. Management will hold a conference call to ... p.m. Eastern Time (details below). Key Recent ... $16 million binding agreement to acquire Vislink Communication Systems. ...
Breaking Biology News(10 mins):
(Date:12/8/2016)... UK (PRWEB) , ... December 08, 2016 , ... ... precision light to control cells — optogenetics — is key to exciting advances ... of the art, spatially patterned light projected via free-space optics stimulates small, transparent ...
(Date:12/8/2016)... England , December 8, 2016 ... has expanded its customisable SureSeq™ NGS panel range with the ... allowing fast and cost-effective study of variants in familial hypercholesterolemia ... number variation (CNV) detection on a single small panel and ... hotspot content. This includes all exons for LDLR , ...
(Date:12/8/2016)... ... December 08, 2016 , ... ... commercial launch of flexible packaging for their exceptionally efficient human mesenchymal stem/stromal ... extends RoosterBio’s portfolio of bioprocess media products engineered to radically streamline culture ...
(Date:12/8/2016)...  Soligenix, Inc. (OTCQB: SNGX) (Soligenix or the ... and commercializing products to treat rare diseases where ... the long-term follow-up data from its Phase 2 ... Defense Regulator (IDR), in the treatment of oral ... undergoing chemoradiation therapy (CRT).  The additional 12-month safety ...
Breaking Biology Technology:
Cached News: