HOME >> BIOLOGY >> NEWS
New software streamlines the search for disease-causing genes

One of the greatest challenges in molecular medicine is identifying the genes that cause specific diseases often a painstaking process requiring months of laboratory trial and error. Now researchers have designed a computer program with the potential for dramatically speeding up the search for disease-causing genes and hastening the discovery of new drugs to treat a wide range of genetic illnesses.

The new software called Digital Disease is described in a study in the June 8 issue of the journal Science.

"The beauty of our software is that it runs in under a second on a computer instead of taking months to years in a lab," says Jonathan Usuka, a graduate student in chemistry and co-author of the Science study.

Usuka developed Digital Disease in collaboration with colleagues at the Roche pharmaceutical company, where he has been working as a part-time consultant while completing his doctoral dissertation.

Of mice and men

"The idea behind Digital Disease is shockingly simple," Usuka says. The software scans databases containing computerized maps of DNA molecules, then instantly locates irregularities in genes that might be responsible for cancer, diabetes and other ailments. Instead of searching through maps of the human genome, Digital Disease scans the DNA of mice, which are genetically similar to people.

"Human genes and mouse genes are about 80 percent identical," Usuka points out, "so if you can identify a genetic mutation in mice, you can easily locate the same mutation in humans."

Genes are located on chromosomes, which are actually molecules of DNA. Each gene, in turn, is made up of thousands of chemical subunits called nucleotides strung together in a specific sequence.

Every nucleotide contains one of four chemicals known by the abbreviations A, T, C and G. The order in which the four nucleotides occur determines how a gene functions and its ultimate effect on the physical makeup of both people and mice - everything f
'"/>

Contact: Mark Shwartz
mshwartz@stanford.edu
650-723-9296
Stanford University
6-Jun-2001


Page: 1 2 3 4

Related biology news :

1. U of T microbiologists achieve results with pattern recognition software
2. New software developed at Rensselaer predicts promising ingredients for new drugs
3. Genetic testing, computer risk-assessment software prove effective in predicting breast cancer
4. Virginia Bioinformatics Institute and Phenomenome Discoveries developing software to allow visualization of genes and proteins
5. DNA gene chips and novel software used to describe kidney development
6. Officials design Web-based software for managing hazardous chemicals
7. New research software to simulate biochemical processes
8. Genome scientists muster computer software tools for handling the flood of raw data from the Human Genome Project and related efforts
9. MTU researchers develop new software to help clean up contamination sites
10. Screening technique streamlines search for anticancer drugs
11. Leader in cancer treatment and prevention research honored

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/2/2016)... 2016 Perimeter Surveillance & Detection ... Physical Infrastructure, Support & Other Service  The ... offers comprehensive analysis of the global Border Security ... revenues of $17.98 billion in 2016. Now: ... leader in software and hardware technologies for advanced video ...
(Date:5/16/2016)...   EyeLock LLC , a market leader of ... an IoT Center of Excellence in Austin, ... of embedded iris biometric applications. EyeLock,s iris ... security with unmatched biometric accuracy, making it the most ... EyeLock,s platform uses video technology to deliver a fast ...
(Date:4/28/2016)... BANGALORE, India , April 28, 2016 /PRNewswire/ ... product subsidiary of Infosys (NYSE: INFY ), and ... global partnership that will provide end customers with ... banking and payment services.      (Logo: http://photos.prnewswire.com/prnh/20130122/589162 ... area for financial services, but it also plays a fundamental ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... ... June 23, 2016 , ... ClinCapture, the only ... Center and will showcase its product’s latest features from June 26 to June ... scientific poster on Disrupting Clinical Trials in The Cloud during the conference. ...
(Date:6/23/2016)... ... June 23, 2016 , ... ... of intelligent tools designed, tuned and optimized exclusively for Okuma CNC machining centers ... The result of a collaboration among several companies with expertise in toolholding, cutting ...
(Date:6/23/2016)... June 23, 2016 ReportsnReports.com ... report to its pharmaceuticals section with historic and ... and much more. Complete report on ... pages, profiling 15 companies and supported with 261 ... http://www.reportsnreports.com/reports/601420-global-cell-culture-media-industry-2016-market-research-report.html . The Global Cell ...
(Date:6/22/2016)... Research and Markets has announced the addition of the "Biomarkers: ... The global biomarkers market has grown ... market is expected to grow at a five-year compound annual growth ... billion in 2015 to $96.6 billion in 2020. ... 2020) are discussed. As well, new products approved in 2013 and ...
Breaking Biology Technology:
Cached News: