HOME >> BIOLOGY >> NEWS
New software streamlines the search for disease-causing genes

One of the greatest challenges in molecular medicine is identifying the genes that cause specific diseases often a painstaking process requiring months of laboratory trial and error. Now researchers have designed a computer program with the potential for dramatically speeding up the search for disease-causing genes and hastening the discovery of new drugs to treat a wide range of genetic illnesses.

The new software called Digital Disease is described in a study in the June 8 issue of the journal Science.

"The beauty of our software is that it runs in under a second on a computer instead of taking months to years in a lab," says Jonathan Usuka, a graduate student in chemistry and co-author of the Science study.

Usuka developed Digital Disease in collaboration with colleagues at the Roche pharmaceutical company, where he has been working as a part-time consultant while completing his doctoral dissertation.

Of mice and men

"The idea behind Digital Disease is shockingly simple," Usuka says. The software scans databases containing computerized maps of DNA molecules, then instantly locates irregularities in genes that might be responsible for cancer, diabetes and other ailments. Instead of searching through maps of the human genome, Digital Disease scans the DNA of mice, which are genetically similar to people.

"Human genes and mouse genes are about 80 percent identical," Usuka points out, "so if you can identify a genetic mutation in mice, you can easily locate the same mutation in humans."

Genes are located on chromosomes, which are actually molecules of DNA. Each gene, in turn, is made up of thousands of chemical subunits called nucleotides strung together in a specific sequence.

Every nucleotide contains one of four chemicals known by the abbreviations A, T, C and G. The order in which the four nucleotides occur determines how a gene functions and its ultimate effect on the physical makeup of both people and mice - everything f
'"/>

Contact: Mark Shwartz
mshwartz@stanford.edu
650-723-9296
Stanford University
6-Jun-2001


Page: 1 2 3 4

Related biology news :

1. U of T microbiologists achieve results with pattern recognition software
2. New software developed at Rensselaer predicts promising ingredients for new drugs
3. Genetic testing, computer risk-assessment software prove effective in predicting breast cancer
4. Virginia Bioinformatics Institute and Phenomenome Discoveries developing software to allow visualization of genes and proteins
5. DNA gene chips and novel software used to describe kidney development
6. Officials design Web-based software for managing hazardous chemicals
7. New research software to simulate biochemical processes
8. Genome scientists muster computer software tools for handling the flood of raw data from the Human Genome Project and related efforts
9. MTU researchers develop new software to help clean up contamination sites
10. Screening technique streamlines search for anticancer drugs
11. Leader in cancer treatment and prevention research honored

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New software streamlines the search for disease causing genes

(Date:11/18/2014)... WASHINGTON , Nov. 18, 2014  The ... Security Industry Association today jointly announce the formation ... and release of its Identity and Biometric ... (Framework). The Framework received official support from BORDERPOL, ... governments to improve and provide expertise regarding border ...
(Date:11/18/2014)... Md. , Nov. 17, 2014 The Parenteral ... and U.S. regulatory agencies will speak and at least seven ... Metrics Conference at the Omni Shoreham Hotel in ... pleased once again to have significant support from the regulatory ... Europe in our effort to help ...
(Date:11/15/2014)... we may still be a few years away from the ... gain instant access to all that ailed his patients, mobile ... for monitoring and measuring our health are cropping up in ... tad Orwellian to some, but a new survey suggests that ... into their healthcare regime. These are some of ...
Breaking Biology News(10 mins):Identity Management, Document Authentication and Biometric Companies Form "The Airport Entry and Exit Working Group", Releasing the Framework to Help Guide the Department of Homeland Security and Congress Towards Solutions 2Identity Management, Document Authentication and Biometric Companies Form "The Airport Entry and Exit Working Group", Releasing the Framework to Help Guide the Department of Homeland Security and Congress Towards Solutions 3FDA's Janet Woodcock, EMA's Emer Cooke Headline PDA Quality Metrics Conference 2Americans May Be Ready for a Brave New World of Healthcare 2Americans May Be Ready for a Brave New World of Healthcare 3Americans May Be Ready for a Brave New World of Healthcare 4
(Date:11/18/2014)... November 17, 2014 Athena Signature Series: Turning ... Dr. Beverly Emerson, a professor in the Regulatory Biology Laboratory ... most recent discovery points to an “off switch” for drug ... and how her local research is making a global impact ... findings and then join host Cheryl K. Goodman, CEO of ...
(Date:11/18/2014)... FL (PRWEB) November 18, 2014 Brothers ... announced the launch of PAWSitively Curing Cancer, Inc ... This new 501(c) (3) non-profit organization is dedicated to ... donated goes directly to the University of Florida ... partner with PAWSitively Curing Cancer as the recipient of ...
(Date:11/18/2014)... INCLINE VILLAGE, Nev. , Nov. 18, 2014 /PRNewswire/ ... ) today announced that in connection with the acquisition ... approximately $42.7 million in connection with the termination of ... the full principal amount outstanding of $40 million, accrued ... October 2013, PDL entered into a structured financing transaction ...
(Date:11/18/2014)... 2014  Novira Therapeutics, Inc., a privately held biopharmaceutical ... hepatitis B virus (HBV) infection, today announced that ... Scientific Advisory Board (SAB).  "We are ... Christian S. Schade , Chief Executive Officer of Novira.  ... will be invaluable to Novira as our lead core ...
Breaking Biology Technology:PAWSitively Curing Cancer, Inc. Launched By Two Children for National Pet Cancer Awareness Month 2PAWSitively Curing Cancer, Inc. Launched By Two Children for National Pet Cancer Awareness Month 3PDL BioPharma Announces Successful Conclusion of Debt Financing Agreement with Durata Therapeutics 2Novira Therapeutics Announces Appointment of Brian F. Daniels, M.D., to its Scientific Advisory Board 2Novira Therapeutics Announces Appointment of Brian F. Daniels, M.D., to its Scientific Advisory Board 3
Cached News: