New statistical method links multiple genes to common complex diseases

Lance Hahn analyzed 10 functional polymorphisms that alter the levels of the suspect estrogen metabolites. When they looked at the polymorphisms individually, he and his colleagues found no indication of increased cancer risk. It was only when they looked at different combinations that they found that women with four specific polymorphisms were significantly more likely to develop breast cancer than those with only three, two or one of these gene variants.

They found this complex association by applying their technique to the genetic information that Parl had compiled on 200 women with breast cancer and an age-matched group of 200 female patients without the illness. First, they constructed a series of tables that compare pairs of polymorphisms. Because a person can inherit a given polymorphism from her father, mother or both parents, each table has nine cells. In each cell, they calculate the number of subjects with breast cancer and the number of control subjects without the illness who have the indicated pair of polymorphisms. If the number with cancer is higher, then the cell is listed as high risk; if the number without cancer is higher, then it is considered low risk. If none of the subjects have a particular combination of the two polymorphisms, the cell is labeled as empty.

The researchers constructed these tables for all possible pairs of polymorphisms. Then they constructed similar tables for all combinations of three, four, five all the way up to nine polymorphisms. By examining the pattern of high and low risks in these tables, the geneticists determined that only one combinationfour polymorphisms in three genesincreased an individuals cancer risk. Moores approach isnt limited to analyzing interactions among three or four genes. Using machine learning algorithms and a new multi-processor supercomputer on campus, he estimates that they will be able to search for similar interactions among as many as 20 genes selected from a list of thousands

Contact: David F. Salisbury
Vanderbilt University

Page: 1 2 3 4

Related biology news :

1. Published research contains high level of statistical errors
2. Fears of gene-therapy DNA passed to next generation statistically unfounded: Penn geneticists estimates affect FDA gene-therapy policy
3. OHSU researchers discover possible method for early detection, prevention of premature birth
4. Japanese researchers develop novel method of introducing transgenes into animals
5. New screening method turns up potential compound for treating anthrax
6. Radiologists provide safe delivery method for gene therapy
7. New method is first to mimic subtle genetic changes
8. New method for determining age of artifacts fills chronological gap for scientists
9. Proven method of bone analysis may clarify human origins
10. UVa researchers describe method of protecting chromosomes during cell division
11. Computer method identifies potentially active enzymes

Post Your Comments:

(Date:10/5/2018)... ... October 04, 2018 , ... ... University of Illinois Extension and Monroe County Economic Development Corporation (EDC), has ... Institute of Food and Agriculture (NIFA) Non-Land Grant College of Agriculture (NLGCA) ...
(Date:10/3/2018)... , ... October 03, 2018 , ... ... York City, announces the appointment of healthcare visionary, Jimmy Lee, as Strategic Advisor ... over 30 years of healthcare industry experience. As a Senior Executive at Anthem, ...
(Date:10/2/2018)... ... October 02, 2018 , ... Through this webinar, sponsored by ... They will also learn the role of calcium kinetics in cardiac safety testing. The ... officer at PPSC Biography; and Tsang Wai Lam, an assay development scientist at PPSC. ...
Breaking Biology News(10 mins):
(Date:9/27/2018)... , ... September 26, 2018 , ... ... are way ahead of their primary care physicians, according to a new Zeldis ... study, patients and doctors were asked about consumer adoption of fitness and health ...
(Date:9/24/2018)... ... September 24, 2018 , ... ReGrow Helmet , ... highest quality and most affordable option for hair regrowth in the comfort of one’s ... on October 2, 2018. , The sophisticated design and advanced technology of the ...
(Date:9/15/2018)... ... 14, 2018 , ... Nationally recognized public accounting and consulting firm Cherry ... of the Firm’s Nashville practice, on her appointment to Launch Tennessee’s Board ... named Managing Partner of the Firm’s Nashville practice in December 2017 . In this ...
(Date:9/12/2018)... ... September 12, 2018 , ... NDA ... professional and former Senior Director of Regulatory Affairs and Quality Systems at WellDoc, ... Director of Regulatory Affairs and Quality Systems at WellDoc, Inc., she conducted quality ...
Breaking Biology Technology:
Cached News: