HOME >> BIOLOGY >> NEWS
New study clarifies connection of brain and heart failure

y inducing the release of mediators that do penetrate the barrier. These neuroactive substances are released in excess by peripheral tissues under the stress of heart failure and signal the brain to alter volume regulation and autonomic function. Interestingly, the cardiovascular regions of forebrain that sense and respond to circulating peptides also process the signals originating in cardiovascular afferent nerves and are capable of modulating cardiovascular reflexes.

Until now, the potential importance of humoral heart-brain signaling in the pathogenesis of heart has not been fully examined. A new study summarizes recent studies supporting the concept that the forebrain plays a critical role in the pathogenesis of ischemia-induced heart failure and suggesting that the forebrain contribution must be considered in designing therapeutic strategies. Of particular emphasis in this study is the concept of forebrain signaling by neuroactive products of the renin-angiotensin system and the immune system.

A New Study

The authors of "Heart Failure and the Brain: New Perspectives," are Joseph Francis, Zhi-Hua Zhang, Shun-Guang Wei, and Alan Kim Johnson, from the University of Iowa and Robert B. Felder and Robert M. Weiss, representing the Research Service, Department of Veterans Affairs Medical Center, all in Iowa City, IA. Their findings appear in the February 2003 edition of the American Journal of Physiology Regulatory, Integrative and Comparative Physiology.

Methodology

A rat model with ischemia-induced heart failure allowed both acute and chronic interventions to address the key questions regarding the contribution of the forebrain to the progression to heart failure after a myocardial infarction (MI), more commonly known as a heart attack. The key question to be addressed was "How important is forebrain activation to the course of heart failure after MI?"

To further define the mechanisms activating t
'"/>

Contact: Donna Krupa
djkrupa1@aol.com
703-527-7357
American Physiological Society
18-Mar-2003


Page: 1 2 3 4

Related biology news :

1. Student science contest participation influences study, career choices, alumni say
2. New study shows hope for treating inhalant abuse
3. International study findings link acne-like rash to effectiveness of new targeted cancer treatment
4. Cigarette smoke causes breaks in DNA and defects to a cells chromosomes, Pitt study finds
5. New study indicates arsenic could be suitable as first-line treatment in type of leukaemia
6. Phase II trials of second-generation antisense cancer drug planned following successful early study
7. Preclinical safety study shows adipose-derived stem cells improve heart function after heart attack
8. Indiana University, EPA to study airborne PCBs
9. K-State, other universities to study how climate affects plant evolution
10. USC study links historical increases in life span to lower childhood exposure to infection
11. Washington University in St. Louis leads group studying aging process

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/19/2016)... 2016 The new GEZE SecuLogic ... web-based "all-in-one" system solution for all door components. It ... the door interface with integration authorization management system, and ... The minimal dimensions of the access control and the ... installations offer considerable freedom of design with regard to ...
(Date:4/14/2016)... TEL AVIV, Israel , April 14, 2016 /PRNewswire/ ... in Behavioral Authentication and Malware Detection, today announced the ... has already assumed the new role. Goldwerger,s ... for BioCatch, on the heels of the deployment of ... In addition, BioCatch,s behavioral biometric technology, which discerns unique ...
(Date:3/31/2016)... , March 31, 2016  Genomics firm Nabsys has ... CEO, Barrett Bready , M.D., who returned to ... the original technical leadership team, including Chief Technology Officer, ... Product Development, Steve Nurnberg and Vice President of Software ... the company. Dr. Bready served as CEO ...
Breaking Biology News(10 mins):
(Date:5/26/2016)... 2016 Despite the volatility that continues ... space. Today,s pre-market research on ActiveWallSt.com directs the investor community,s ... RDUS ), Cerus Corp. (NASDAQ: CERS ... Five Prime Therapeutics Inc. (NASDAQ: FPRX ). Register ... http://www.activewallst.com/ On Wednesday, shares in ...
(Date:5/26/2016)... , ... May 26, 2016 , ... ... FireflySci cuvettes are used in leading laboratories all over the globe. Their cute ... In addition to manufacturing awesome cuvettes, FireflySci makes spectrophotometer calibration standards that never ...
(Date:5/25/2016)... ... May 25, 2016 , ... The Ankle Plating ... options designed to address fractures of the distal tibia and fibula. This system ... Ankle Plating System 3 is composed of seven plate families that span the ...
(Date:5/25/2016)... ... ... Scientists at the University of Athens say they have evidence that the variety ... that could lead to one good one. Surviving Mesothelioma has just posted an article ... team evaluated 98 mesothelioma patients who got a second kind of drug ...
Breaking Biology Technology:
Cached News: