HOME >> BIOLOGY >> NEWS
New study clarifies connection of brain and heart failure

y inducing the release of mediators that do penetrate the barrier. These neuroactive substances are released in excess by peripheral tissues under the stress of heart failure and signal the brain to alter volume regulation and autonomic function. Interestingly, the cardiovascular regions of forebrain that sense and respond to circulating peptides also process the signals originating in cardiovascular afferent nerves and are capable of modulating cardiovascular reflexes.

Until now, the potential importance of humoral heart-brain signaling in the pathogenesis of heart has not been fully examined. A new study summarizes recent studies supporting the concept that the forebrain plays a critical role in the pathogenesis of ischemia-induced heart failure and suggesting that the forebrain contribution must be considered in designing therapeutic strategies. Of particular emphasis in this study is the concept of forebrain signaling by neuroactive products of the renin-angiotensin system and the immune system.

A New Study

The authors of "Heart Failure and the Brain: New Perspectives," are Joseph Francis, Zhi-Hua Zhang, Shun-Guang Wei, and Alan Kim Johnson, from the University of Iowa and Robert B. Felder and Robert M. Weiss, representing the Research Service, Department of Veterans Affairs Medical Center, all in Iowa City, IA. Their findings appear in the February 2003 edition of the American Journal of Physiology Regulatory, Integrative and Comparative Physiology.

Methodology

A rat model with ischemia-induced heart failure allowed both acute and chronic interventions to address the key questions regarding the contribution of the forebrain to the progression to heart failure after a myocardial infarction (MI), more commonly known as a heart attack. The key question to be addressed was "How important is forebrain activation to the course of heart failure after MI?"

To further define the mechanisms activating t
'"/>

Contact: Donna Krupa
djkrupa1@aol.com
703-527-7357
American Physiological Society
18-Mar-2003


Page: 1 2 3 4

Related biology news :

1. Student science contest participation influences study, career choices, alumni say
2. New study shows hope for treating inhalant abuse
3. International study findings link acne-like rash to effectiveness of new targeted cancer treatment
4. Cigarette smoke causes breaks in DNA and defects to a cells chromosomes, Pitt study finds
5. New study indicates arsenic could be suitable as first-line treatment in type of leukaemia
6. Phase II trials of second-generation antisense cancer drug planned following successful early study
7. Preclinical safety study shows adipose-derived stem cells improve heart function after heart attack
8. Indiana University, EPA to study airborne PCBs
9. K-State, other universities to study how climate affects plant evolution
10. USC study links historical increases in life span to lower childhood exposure to infection
11. Washington University in St. Louis leads group studying aging process

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/19/2016)... The new GEZE SecuLogic access ... "all-in-one" system solution for all door components. It can ... door interface with integration authorization management system, and thus ... minimal dimensions of the access control and the optimum ... offer considerable freedom of design with regard to the ...
(Date:4/14/2016)... 2016 BioCatch ™, the ... announced the appointment of Eyal Goldwerger as ... Goldwerger,s leadership appointment comes at a time of ... deployment of its platform at several of the world,s ... discerns unique cognitive and physiological factors, is a winner ...
(Date:3/31/2016)... 2016  Genomics firm Nabsys has completed a financial ... Bready , M.D., who returned to the company in ... leadership team, including Chief Technology Officer, John Oliver ... Nurnberg and Vice President of Software and Informatics, ... Dr. Bready served as CEO of Nabsys from ...
Breaking Biology News(10 mins):
(Date:5/3/2016)... ... May 03, 2016 , ... ... unique bioresearch materials from laboratories across the globe, today announced the availability of ... the pace of research toward treatment and prevention measures for the Zika virus, ...
(Date:5/3/2016)... May 3, 2016  Dr. Thomas P. McHugh ... The Woodlands, Texas , now offers ... of treated fat cells in just 25-minutes, leaving a ... 90 percent of Americans report feeling bothered by excess ... reduction procedures are a growing industry. This innovative new ...
(Date:5/2/2016)... Q BioMed Inc. (QBIO), a ... Research Inc. will be attending the Association for Research ... May 1-5, 2016 in Seattle Washington ... vendors and research partners. The meeting provides organizations the ... collaborative opportunities for the MAN-01 program for treatment of ...
(Date:5/2/2016)... ... May 02, 2016 , ... ... the pre-launch success of their revolutionary, veterinarian-designed product for indoor cats. The NoBowl ... and play with their food the way nature intended. NoBowls make cats happy ...
Breaking Biology Technology:
Cached News: