HOME >> BIOLOGY >> NEWS
New study provides first linkage of fetal alcohol exposure and enlarged heart

August 25, 2003 (Bethesda, MD) -- Cardiac malformations exist in children with fetal alcohol syndrome and animal models of prenatal alcohol exposure, and an enlarged heart (cardiac hypertrophy) has been found in children with fetal alcohol syndrome. The high incidence of heart defects indicates that alcoholism during pregnancy has to be considered as a serious and preventable cause of congenital heart disease.

Moreover, low birth weight is linked to a later emergence of cardiovascular and metabolic medical disorders, including ischemic heart disease, hypertension, insulin resistance, and non-insulin-dependent diabetes. Accordingly, many scientists have suspected that changes in the fetal environment produce physiological adaptations by the fetus that lead to small birth weight. Such adaptations, known as fetal programming, may be beneficial before birth but may also produce adverse outcomes for years to come.

One consistent feature found in animal research models is that low birth weight is associated with prenatal exposure to glucocorticoid steroids (any compound capable of significantly influencing intermediary metabolism, such as promotion of hepatic glycogen deposition, and of exerting a clinically useful anti-inflammatory effect). Even brief prenatal exposure to elevated glucocorticoids can result in permanent adverse changes in the adult offspring's cardiovascular system. Glucocorticoids are important in normal development, but excessive exposure through the mother leads to reduced birth weight.

Scientists have also found that very low levels of steroids produced by the adrenal glands (corticosterone or (Cort)) are sufficient to normalize birth weight and increase fetal Cort levels. However, removal of one or both adrenal glands in the mother will cause reduced birth weight and decreased levels of maternal plasma Cort.

As fetal adrenals start functioning during the last week of gestation, maternal Cort may affect fetal
'"/>

Contact: Donna Krupa
djkrupa1@aol.com
703-527-7357
American Physiological Society
25-Aug-2003


Page: 1 2 3 4 5

Related biology news :

1. Student science contest participation influences study, career choices, alumni say
2. New study shows hope for treating inhalant abuse
3. International study findings link acne-like rash to effectiveness of new targeted cancer treatment
4. Cigarette smoke causes breaks in DNA and defects to a cells chromosomes, Pitt study finds
5. New study indicates arsenic could be suitable as first-line treatment in type of leukaemia
6. Phase II trials of second-generation antisense cancer drug planned following successful early study
7. Preclinical safety study shows adipose-derived stem cells improve heart function after heart attack
8. Indiana University, EPA to study airborne PCBs
9. K-State, other universities to study how climate affects plant evolution
10. USC study links historical increases in life span to lower childhood exposure to infection
11. Washington University in St. Louis leads group studying aging process

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/20/2017)... DAL ) customers now can use fingerprints instead of their ... (DCA). ... launches biometrics to board aircraft at Reagan Washington National Airport ... Delta,s biometric boarding pass experience that launched in May at ... process to allow eligible Delta SkyMiles Members who are enrolled in CLEAR ...
(Date:6/14/2017)... IBM ) is introducing several innovative partner startups at VivaTech ... startups and global businesses, taking place in Paris ... will showcase the solutions they have built with IBM Watson ... France is one of the most dynamic ... in the number of startups created between 2012 and 2015*, ...
(Date:5/16/2017)... 2017   Bridge Patient Portal , an ... MD EMR Systems , an electronic medical record ... have established a partnership to build an interface ... GE Centricity™ products, including Centricity Practice Solution (CPS), ... These new integrations will allow healthcare delivery networks ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... ... October 10, 2017 , ... ... conjugate (ADC) therapeutics, today confirmed licensing rights that give it exclusive global ... technology developed in collaboration with Children’s Hospital Los Angeles (CHLA). Additionally, ...
(Date:10/10/2017)... , Oct. 10, 2017 SomaGenics announced ... the NIH to develop RealSeq®-SC (Single Cell), expected to ... profiling small RNAs (including microRNAs) from single cells using ... highlights the need to accelerate development of approaches to ... "New techniques for measuring levels of ...
(Date:10/9/2017)... ... , ... The award-winning American Farmer television series will feature 3 Bar Biologics ... at 8:30aET on RFD-TV. , With global population estimates nearing ten billion people ... to feed a growing nation. At the same time, many of our valuable resources ...
(Date:10/7/2017)... Arizona (PRWEB) , ... October ... ... 15 years’ experience providing advanced instruments and applications consulting for microscopy and ... in-house expertise in application consulting, Nanoscience Analytical offers a broad range of ...
Breaking Biology Technology:
Cached News: