HOME >> BIOLOGY >> NEWS
New study rebuts claims about Icelandic genetic heterogeneity

There has been some controversy in the media and within the scientific research community concerning whether Icelanders are genetically homogenous or heterogeneous relative to other European populations.

Following an article published in Annals of Human Genetics in January 2003 by E. rnason, who concluded that Icelanders were one of the most heterogeneous populations in Europe, researchers from deCODE Genetics and the University of Oxford, have published an article in Annals of Human Genetics (issue 67:4, July 2003) corroborating findings from earlier studies that Iceland is indeed home to one of the most homogenous gene pools in Europe.

This latest research article, 'A Reassessment of Genetic Diversity in Icelanders: Strong Evidence from Multiple Loci for Relative Homogeneity Caused by Genetic Drift' by A. Helgason, G. Nicholson, K. Stefnsson and P. Donnelly, both greatly expands sample sizes from individual populations and the number of genetic loci analysed, and uses population genetics simulations to demonstrate that genetic drift, not admixture (as claimed by E. rnason), has been the overriding factor influencing patterns of genetic variation in Iceland. Moreover, these simulations also reveal that the summary statistics (gene diversity and mean pairwise mutational differences) used by E. rnason, to argue for the relative genetic heterogeneity of Icelanders in his analysis of mitochondrial DNA (mtDNA) sequences, are poor comparative measures of genetic diversity in closely related populations such as those of Iceland and other European countries.

Agnar Helgason, corresponding author on the new study, says: "A consideration of 83 unlinked nuclear SNPs, 14 serogenetic loci, Y-chromosome haplotypes constructed from five microsatellites and mtDNA HVS1 and HVS2 control region sequences, provides a clear and consistent picture of Icelanders being amongst the more genetically homogeneous populations in Europe, characterised by small effective p
'"/>

Contact: Melanie Thomson
melanie.thomson@oxon.blackwellpublishing.com
44-0-1865-476270
Blackwell Publishing Ltd.
19-Aug-2003


Page: 1 2

Related biology news :

1. Student science contest participation influences study, career choices, alumni say
2. New study shows hope for treating inhalant abuse
3. International study findings link acne-like rash to effectiveness of new targeted cancer treatment
4. Cigarette smoke causes breaks in DNA and defects to a cells chromosomes, Pitt study finds
5. New study indicates arsenic could be suitable as first-line treatment in type of leukaemia
6. Phase II trials of second-generation antisense cancer drug planned following successful early study
7. Preclinical safety study shows adipose-derived stem cells improve heart function after heart attack
8. Indiana University, EPA to study airborne PCBs
9. K-State, other universities to study how climate affects plant evolution
10. USC study links historical increases in life span to lower childhood exposure to infection
11. Washington University in St. Louis leads group studying aging process

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/13/2018)... ... November 13, 2018 , ... Fluence Bioengineering today unveiled ... VYPR 2 is well suited for sole-source and supplemental lighting applications addressing virtually ... , “As an all-purpose light which can be adapted to virtually any setting, ...
(Date:11/13/2018)... ... 12, 2018 , ... Board-certified periodontist Dr. Jin Y. Kim, with two locations ... in Santa Ana, CA and surrounding areas, who want to explore permanent, long-term replacement ... Kim regularly helps patients get the advantages that come with All-on-4® dental implants ...
(Date:11/9/2018)... Pa. (PRWEB) , ... November 08, 2018 , ... ... with advanced touch screen control. Heating blocks, also known as dry bath incubators ... variety of tubes and containers. , For the new heating blocks, Boekel ...
Breaking Biology News(10 mins):
(Date:11/7/2018)... ... November 07, 2018 , ... Diversified Technologies, Inc. (DTI) ... the Arizona Center for Algae Technology and Innovation at ASU. Funded by a USDA ... for those involved with algal and predator control applications. , Algae ponds get up ...
(Date:11/5/2018)... ... 2018 , ... Frederick National Laboratory for Cancer Research is ... research and education in the Frederick County area. , Frederick Center for ... STEM-based undergraduate and graduate degree and certificate programs offered by partnering colleges or ...
(Date:11/5/2018)... (PRWEB) , ... November 05, 2018 , ... ... launching live educational support for healthcare professionals through its website, http://www.glycomark.com , ... offer a live chat and video option via the website in November from ...
(Date:11/3/2018)... Va. (PRWEB) , ... November 01, 2018 , ... ... first-ever Metrics Champion Consortium Summit. Dr. Jean Mulinde, Senior Advisor, Division of Clinical ... manage risk, monitor safety and ensure data reliability. , What should clinical research ...
Breaking Biology Technology:
Cached News: