HOME >> BIOLOGY >> NEWS
New study shows hope for treating inhalant abuse

UPTON, N.Y. -- A new study by scientists at the U.S. Department of Energy's Brookhaven National Laboratory suggests that vigabatrin (a.k.a. gamma vinyl-GABA or GVG) may block the addictive effects of toluene, a substance found in many household products commonly used as inhalants. These results broaden the promise of GVG as a potential treatment for a variety of addictions. The study will be published in the December 1, 2004 issue of Synapse, available online September 30.

Inhalant abuse or "huffing" continues to grow as a serious health problem: According to the National Institute on Drug Abuse, the number of new inhalant users increased from 627,000 in 1994 to 1.2 million in 2000. The chronic use of inhalants has been associated with heart, liver, kidney, and brain damage -- and can even result in sudden death.

The Brookhaven Lab study demonstrates that animals previously trained to expect toluene in a given location spent far less time "seeking" toluene in that location after being treated with GVG than animals treated with a placebo. This elimination of conditioned place preference -- a model of craving in which animals develop a preference for a place where they have previously had access to a drug, even when the drug is absent -- is similar to the aversion seen in Brookhaven's earlier studies of GVG with nicotine and heroin.

"The findings of this study extend the potential value of GVG to treat addiction," says Stephen Dewey, the Brookhaven Lab neuroanatomist who led the study. "More importantly, our results show promise in treating inhalant abuse as it continues to grow as a problem among adolescents." There are currently no pharmaceutical treatments for inhalant abuse.

The study was conducted by putting rats through a series of conditioning tests. The tests were intended to condition the animals to learn which chambers of a three-chambered apparatus contained toluene vapors. On the final day of the study, scientist
'"/>

Contact: Dennis Tartaglia
dennist@mbooth.com
212-481-7000
M Booth & Associates
30-Sep-2004


Page: 1 2 3

Related biology news :

1. Student science contest participation influences study, career choices, alumni say
2. International study findings link acne-like rash to effectiveness of new targeted cancer treatment
3. Cigarette smoke causes breaks in DNA and defects to a cells chromosomes, Pitt study finds
4. New study indicates arsenic could be suitable as first-line treatment in type of leukaemia
5. Phase II trials of second-generation antisense cancer drug planned following successful early study
6. Preclinical safety study shows adipose-derived stem cells improve heart function after heart attack
7. Indiana University, EPA to study airborne PCBs
8. K-State, other universities to study how climate affects plant evolution
9. USC study links historical increases in life span to lower childhood exposure to infection
10. Washington University in St. Louis leads group studying aging process
11. Simian virus 40 not associated with non-Hodgkin lymphoma, study shows

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/23/2020)... , ... August 21, 2020 , ... ... Corporation has been published and is now available on the company’s global ... diffraction—serves the X-ray analysis community, presenting current news and crystallographic research. , ...
(Date:8/21/2020)... , ... August 20, 2020 , ... ... Hassan Movahhed , a Clinical Operations executive with expertise in clinical trial ... joined the firm as an Expert Consultant. Throughout his career, Mr. Movahhed has ...
(Date:8/7/2020)... ... August 06, 2020 , ... Nine middle ... National STEM Scholar Program, a unique professional development program that provides advanced STEM ... middle school science teachers nationwide. , Created in partnership between the National Stem ...
Breaking Biology News(10 mins):
(Date:8/3/2020)... (PRWEB) , ... August 03, 2020 , ... ... collection, today announced Jim Corrigan, President and CEO has been named one of ... broad cross-section of industry sectors, PharmaVoice 100 honorees are selected based on how ...
(Date:7/31/2020)... (PRWEB) , ... July 29, 2020 , ... ... reliable, solid-state radar transmitter systems that can be configured to drive Klystrons, TWTs, ... controller that can drive one or two switches in a push-pull configuration; yielding ...
(Date:7/31/2020)... , ... July 29, 2020 , ... ... of the top radiation centers in 16 countries, has reached its 20th anniversary ... is now in routine use at top universities including University of Pennsylvania, University ...
(Date:7/18/2020)... , ... July 16, 2020 , ... “We are thrilled ... Wave Bioactives. “It’s the only technology of its kind on the market and we ... onions with the protective capacity of traditional cultured ingredients, creating a natural way to ...
Breaking Biology Technology:
Cached News: