HOME >> BIOLOGY >> NEWS
New study shows hope for treating inhalant abuse

UPTON, N.Y. -- A new study by scientists at the U.S. Department of Energy's Brookhaven National Laboratory suggests that vigabatrin (a.k.a. gamma vinyl-GABA or GVG) may block the addictive effects of toluene, a substance found in many household products commonly used as inhalants. These results broaden the promise of GVG as a potential treatment for a variety of addictions. The study will be published in the December 1, 2004 issue of Synapse, available online September 30.

Inhalant abuse or "huffing" continues to grow as a serious health problem: According to the National Institute on Drug Abuse, the number of new inhalant users increased from 627,000 in 1994 to 1.2 million in 2000. The chronic use of inhalants has been associated with heart, liver, kidney, and brain damage -- and can even result in sudden death.

The Brookhaven Lab study demonstrates that animals previously trained to expect toluene in a given location spent far less time "seeking" toluene in that location after being treated with GVG than animals treated with a placebo. This elimination of conditioned place preference -- a model of craving in which animals develop a preference for a place where they have previously had access to a drug, even when the drug is absent -- is similar to the aversion seen in Brookhaven's earlier studies of GVG with nicotine and heroin.

"The findings of this study extend the potential value of GVG to treat addiction," says Stephen Dewey, the Brookhaven Lab neuroanatomist who led the study. "More importantly, our results show promise in treating inhalant abuse as it continues to grow as a problem among adolescents." There are currently no pharmaceutical treatments for inhalant abuse.

The study was conducted by putting rats through a series of conditioning tests. The tests were intended to condition the animals to learn which chambers of a three-chambered apparatus contained toluene vapors. On the final day of the study, scientist
'"/>

Contact: Dennis Tartaglia
dennist@mbooth.com
212-481-7000
M Booth & Associates
30-Sep-2004


Page: 1 2 3

Related biology news :

1. Student science contest participation influences study, career choices, alumni say
2. International study findings link acne-like rash to effectiveness of new targeted cancer treatment
3. Cigarette smoke causes breaks in DNA and defects to a cells chromosomes, Pitt study finds
4. New study indicates arsenic could be suitable as first-line treatment in type of leukaemia
5. Phase II trials of second-generation antisense cancer drug planned following successful early study
6. Preclinical safety study shows adipose-derived stem cells improve heart function after heart attack
7. Indiana University, EPA to study airborne PCBs
8. K-State, other universities to study how climate affects plant evolution
9. USC study links historical increases in life span to lower childhood exposure to infection
10. Washington University in St. Louis leads group studying aging process
11. Simian virus 40 not associated with non-Hodgkin lymphoma, study shows

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/28/2017)... , March 28, 2017 The ... Hardware (Camera, Monitors, Servers, Storage Devices), Software (Video Analytics, ... Region - Global Forecast to 2022", published by MarketsandMarkets, ... 2016 and is projected to reach USD 75.64 Billion ... and 2022. The base year considered for the study ...
(Date:3/24/2017)... The Controller General of Immigration from Maldives Mr. Mohamed Anwar ... the prestigious international IAIR Award for the most innovative high security ePassport ... ... Maldives Immigration Controller General, Mr. ... on the right) have received the IAIR award for the "Most innovative ...
(Date:3/23/2017)... , March 23, 2017 The report "Gesture Recognition ... Biometric), Industry, and Geography - Global Forecast to 2022", published by MarketsandMarkets, the ... a CAGR of 29.63% between 2017 and 2022. ... ... ...
Breaking Biology News(10 mins):
(Date:4/20/2017)... , ... April 20, 2017 , ... NetDimensions appoints Bill ... , With over 20 years of experience in the learning technologies industry, Mastin joins ... company within Learning Technologies Group plc (LTG). At LEO, Mastin served as SVP of ...
(Date:4/20/2017)... ... April 20, 2017 , ... Open Therapeutics ... property (IP) sharing and commercialization model. , The Center for Advancing Innovation helps ... of this effort is bringing the IP to the attention of the entrepreneurial ...
(Date:4/19/2017)... (PRWEB) , ... April 18, 2017 , ... ... 1970s and has been a key device for generating monodisperse droplets of known ... droplet processes and for generating monodisperse solid particles by drying monodisperse droplets. ...
(Date:4/19/2017)... ... April 19, 2017 , ... Nobilis Therapeutics Announces ... Seeks to Leverage Clinical Data in its Upcoming Post Traumatic Stress Disorder Trial , ... 81 patient clinical trial assessing efficacy of its NBTX-001, a xenon-based therapeutic in the ...
Breaking Biology Technology:
Cached News: