HOME >> BIOLOGY >> NEWS
New study shows hope for treating inhalant abuse

UPTON, N.Y. -- A new study by scientists at the U.S. Department of Energy's Brookhaven National Laboratory suggests that vigabatrin (a.k.a. gamma vinyl-GABA or GVG) may block the addictive effects of toluene, a substance found in many household products commonly used as inhalants. These results broaden the promise of GVG as a potential treatment for a variety of addictions. The study will be published in the December 1, 2004 issue of Synapse, available online September 30.

Inhalant abuse or "huffing" continues to grow as a serious health problem: According to the National Institute on Drug Abuse, the number of new inhalant users increased from 627,000 in 1994 to 1.2 million in 2000. The chronic use of inhalants has been associated with heart, liver, kidney, and brain damage -- and can even result in sudden death.

The Brookhaven Lab study demonstrates that animals previously trained to expect toluene in a given location spent far less time "seeking" toluene in that location after being treated with GVG than animals treated with a placebo. This elimination of conditioned place preference -- a model of craving in which animals develop a preference for a place where they have previously had access to a drug, even when the drug is absent -- is similar to the aversion seen in Brookhaven's earlier studies of GVG with nicotine and heroin.

"The findings of this study extend the potential value of GVG to treat addiction," says Stephen Dewey, the Brookhaven Lab neuroanatomist who led the study. "More importantly, our results show promise in treating inhalant abuse as it continues to grow as a problem among adolescents." There are currently no pharmaceutical treatments for inhalant abuse.

The study was conducted by putting rats through a series of conditioning tests. The tests were intended to condition the animals to learn which chambers of a three-chambered apparatus contained toluene vapors. On the final day of the study, scientist
'"/>

Contact: Dennis Tartaglia
dennist@mbooth.com
212-481-7000
M Booth & Associates
30-Sep-2004


Page: 1 2 3

Related biology news :

1. Student science contest participation influences study, career choices, alumni say
2. International study findings link acne-like rash to effectiveness of new targeted cancer treatment
3. Cigarette smoke causes breaks in DNA and defects to a cells chromosomes, Pitt study finds
4. New study indicates arsenic could be suitable as first-line treatment in type of leukaemia
5. Phase II trials of second-generation antisense cancer drug planned following successful early study
6. Preclinical safety study shows adipose-derived stem cells improve heart function after heart attack
7. Indiana University, EPA to study airborne PCBs
8. K-State, other universities to study how climate affects plant evolution
9. USC study links historical increases in life span to lower childhood exposure to infection
10. Washington University in St. Louis leads group studying aging process
11. Simian virus 40 not associated with non-Hodgkin lymphoma, study shows

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/14/2019)... ... 2019 , ... CellMax Life , a diagnostics company ... present new findings at the ASCO Gastrointestinal Cancer Symposium in San Francisco this ... this study show CellMax Life’s blood test, based on its proprietary CMxTM platform, ...
(Date:1/10/2019)... ... January 10, 2019 , ... ... gap between inexpensive in vitro studies and significantly more expensive in vivo studies ... efficacy and toxicity. To address this need, researchers have begun to adopt 3D ...
(Date:1/7/2019)... ... , ... Concerto HealthAI, a technology leader in definitive Real ... other key therapeutic areas, and its Chief Executive Officer, Dr. Jeff Elton, will ... entire healthcare landscape, on January 8, 2019, at 2:30 p.m. in San Francisco, ...
Breaking Biology News(10 mins):
(Date:1/24/2019)... , ... January 22, 2019 , ... ... each trial has its own set of assumptions, and RFP creation and management ... evaluating bids is like comparing apples to oranges. These challenges can ultimately lead ...
(Date:1/21/2019)... , ... January 21, 2019 , ... ... newest product line, SporActiv™, for the industrial and institutional cleaning market. MDG’s SporActiv ... residential and commercial cleaning needs. Applications include odor control, floor and tile cleaners, ...
(Date:1/20/2019)... NEW YORK (PRWEB) , ... January 17, 2019 ... ... ordering clinical testing was, until recently, the exclusive purview of physicians. That's changing ... okay. The global direct to consumer (DTC) laboratory testing market totaled $208 million ...
(Date:1/20/2019)... , ... January 17, 2019 , ... ... Platinum Partner announces the launch of a specialized automation technology, titled Automate 3D. ... for automatic generation of models and drawings to deliver to end-users, customers, and ...
Breaking Biology Technology:
Cached News: