HOME >> BIOLOGY >> NEWS
New technique identifies M. tuberculosis genes

For most of this century, tuberculosis, or TB, has not been considered a major disease in the United States. In the late '80s, after a century of steady decline, the number of cases of TB in the United States began to increase due to increases in immigrants from countries where TB is prevalent, homeless people in crowded conditions, the elderly and AIDS patients. Although the increase in cases has been reversed in the last several years, more than 18,000 cases of TB were reported in the United States in 1998. Worldwide, TB remains a serious health problem. The World Health Organization has estimated that one-third of the world's population is infected with Mycobacterium tuberculosis, the bacterium that causes TB.

United States researchers have picked up their efforts over the past decade. One, Josephine Clark-Curtiss, Ph.D., research associate professor of biology at Washington University in St. Louis, and her colleagues have recently identified 15 M. tuberculosis genes that are expressed only when the bacteria are growing in the immune system's prime gatekeeper, a disease-fighting cell called a macrophage.

Using an elaborate new technique that is widely applicable to a host of different research situations, James Graham, Ph.D., a post-doctoral researcher in Clark-Curtiss' lab, captured DNA complementary to messenger RNA (called cDNA) of genes active in human macrophages, cells that engulf and degrade pathogenic bacteria, rendering them harmless.

But in the case of M. tuberculosis, the killer bacteria have found a way, once inside the macrophage, to prevent the development of a macrophage compartment known as the phagolysosome. This key compartment produces a number of enzymes that puts the coup de grace on M.tuberculosis.

Clark-Curtiss believes the 15 genes isolated in her laboratory play important roles in the pathogen's metabolism, propagation and self-protection once i
'"/>

Contact: Tony Fitzpatrick
tony_fitzpatrick@aismail.wustl.edu
314-935-5272
Washington University in St. Louis
27-Sep-1999


Page: 1 2 3 4

Related biology news :

1. ASU researchers demonstrate new technique that improves the power of atomic force micrscopy
2. New technique helps scientists reveal interactions between genes and drugs
3. New technique images gene expression in mice
4. Researchers report major advance in gene therapy technique
5. Busy sequencing technique saves money and time
6. Laser technique used to build micro-polymeric structure on a human hair, without harming it
7. Better techniques needed to predict earthquake hazards, UC study finds
8. Scientists develop new cloning technique that dramatically shortens the search for genes
9. New imaging technique developed to identify breast cancer
10. Imaging technique reveals new structure in retinal cells
11. Statistical technique helps researchers gain more information from a single data run

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/15/2016)... Yissum Research Development Company of the ... the Hebrew University, announced today the formation of ... various human biological indicators. Neteera Technologies has completed its ... investors. ... electromagnetic emissions from sweat ducts, enables reliable and speedy ...
(Date:3/11/2016)... , March 11, 2016 http://www.apimages.com ) ... Cross reference: Picture is available at AP Images ( http://www.apimages.com ) ... DERMALOG will be used to produce the new refugee identity cards. ... biometric innovations, at CeBIT in Hanover next ... from DERMALOG will be used to produce the new refugee identity ...
(Date:3/10/2016)... --  Unisys Corporation (NYSE: UIS ) today announced ... testing its biometric identity solution at the Otay Mesa border ... identify certain non-U.S. citizens leaving the country. ... determine the efficiency and accuracy of using biometric technologies in ... until May 2016. --> the United States ...
Breaking Biology News(10 mins):
(Date:5/26/2016)... , ... May 26, 2016 , ... ... FireflySci cuvettes are used in leading laboratories all over the globe. Their cute ... In addition to manufacturing awesome cuvettes, FireflySci makes spectrophotometer calibration standards that never ...
(Date:5/25/2016)... , ... May 25, 2016 , ... ... a variety of fracture-specific plating options designed to address fractures of the distal ... fixation solutions. , The Acumed Ankle Plating System 3 is composed of seven ...
(Date:5/25/2016)... ... ... Scientists at the University of Athens say they have evidence that the variety of ... could lead to one good one. Surviving Mesothelioma has just posted an article on ... evaluated 98 mesothelioma patients who got a second kind of drug therapy ...
(Date:5/25/2016)... ... 25, 2016 , ... Biohaven Pharmaceutical Holding Company Ltd. (Biohaven) ... company’s orphan drug designation request covering BHV-4157 for the treatment of Spinocerebellar Ataxia ... , Spinocerebellar ataxia is a rare, debilitating neurodegenerative disorder that is estimated ...
Breaking Biology Technology:
Cached News: