HOME >> BIOLOGY >> NEWS
New technique identifies M. tuberculosis genes

For most of this century, tuberculosis, or TB, has not been considered a major disease in the United States. In the late '80s, after a century of steady decline, the number of cases of TB in the United States began to increase due to increases in immigrants from countries where TB is prevalent, homeless people in crowded conditions, the elderly and AIDS patients. Although the increase in cases has been reversed in the last several years, more than 18,000 cases of TB were reported in the United States in 1998. Worldwide, TB remains a serious health problem. The World Health Organization has estimated that one-third of the world's population is infected with Mycobacterium tuberculosis, the bacterium that causes TB.

United States researchers have picked up their efforts over the past decade. One, Josephine Clark-Curtiss, Ph.D., research associate professor of biology at Washington University in St. Louis, and her colleagues have recently identified 15 M. tuberculosis genes that are expressed only when the bacteria are growing in the immune system's prime gatekeeper, a disease-fighting cell called a macrophage.

Using an elaborate new technique that is widely applicable to a host of different research situations, James Graham, Ph.D., a post-doctoral researcher in Clark-Curtiss' lab, captured DNA complementary to messenger RNA (called cDNA) of genes active in human macrophages, cells that engulf and degrade pathogenic bacteria, rendering them harmless.

But in the case of M. tuberculosis, the killer bacteria have found a way, once inside the macrophage, to prevent the development of a macrophage compartment known as the phagolysosome. This key compartment produces a number of enzymes that puts the coup de grace on M.tuberculosis.

Clark-Curtiss believes the 15 genes isolated in her laboratory play important roles in the pathogen's metabolism, propagation and self-protection once i
'"/>

Contact: Tony Fitzpatrick
tony_fitzpatrick@aismail.wustl.edu
314-935-5272
Washington University in St. Louis
27-Sep-1999


Page: 1 2 3 4

Related biology news :

1. ASU researchers demonstrate new technique that improves the power of atomic force micrscopy
2. New technique helps scientists reveal interactions between genes and drugs
3. New technique images gene expression in mice
4. Researchers report major advance in gene therapy technique
5. Busy sequencing technique saves money and time
6. Laser technique used to build micro-polymeric structure on a human hair, without harming it
7. Better techniques needed to predict earthquake hazards, UC study finds
8. Scientists develop new cloning technique that dramatically shortens the search for genes
9. New imaging technique developed to identify breast cancer
10. Imaging technique reveals new structure in retinal cells
11. Statistical technique helps researchers gain more information from a single data run

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/25/2016)... Software, the world-leading supplier of image data management solutions ... data management solution OMERO Plus for the newly established ... Photo - http://photos.prnewswire.com/prnh/20160125/325328LOGO ... analysis measures the characteristics and behavior of cells, tissues ... as health and disease, the presence or absence of ...
(Date:1/20/2016)... Jan. 20, 2016   MedNet Solutions , an ... spectrum of clinical research, is pleased to announce the ... achievements are the result of the company,s laser focus ... eClinical , it,s comprehensive, easy-to-use and highly affordable ... --> Key MedNet growth achievements in 2015 include: ...
(Date:1/13/2016)... January 13, 2016 ... addition of the  "India Biometrics Authentication ... Forecast (2015-2020)"  report to their ... has announced the addition of the  ... - Estimation & Forecast (2015-2020)" ...
Breaking Biology News(10 mins):
(Date:2/8/2016)... , Feb. 8, 2016 Should antibiotic ... bone cement products to prevent infection after standard total ... the experts at ECRI Institute have been fielding a ... or Fighting Your Bottom Line?" --> ... Bottom Line?" --> While there ...
(Date:2/8/2016)... , Feb. 8, 2016  BioElectronics Corporation (OTC ... devices, announced today that it is responding to ... from the Securities and Exchange Commission posted on ... , Chairman of the Board of BioElectronics Corporation ... Business Administration at The Fuqua School of Business, ...
(Date:2/8/2016)... has an active R&D program for the development ... the Group has a unique research and development center in ... developing Bio Control products. Stockton has ... and regulatory guidelines, and is active in more than 35 ... Stockton,s flagship product Timorex Gold ® ...
(Date:2/5/2016)... 2016 ATCC, the premier global biological materials ... medical and life science researchers that are working to ... CDC website . --> ... is a single-stranded RNA virus of the Flaviviridae family, ... and Chikungunya Viruses. Zika virus is transmitted to humans ...
Breaking Biology Technology:
Cached News: