HOME >> BIOLOGY >> NEWS
New technique images gene expression in mice

PHILADELPHIA, PA, June 21, 2004 Fifteen years ago, a new age of genetic medicine seemed right around the corner. As it turns out, identifying genetic flaws has proved easier than getting corrected genes to work in the cells that need them. Researchers at the Departments of Nuclear Medicine (Radiology) and Pediatrics at Case Western Reserve University may be able to help. They have demonstrated a technique that provides a picture of genetic expression in living mice.

The study used genetic material that should theoretically correct the genetic defect that causes cystic fibrosis, one of the most debilitating, and ultimately fatal, genetic diseases. The results of the study were presented at the Society of Nuclear Medicine's 51st Annual Meeting.

Using the radioactive tracer iodine-125 FIAU and a custom-built small animal imaging system that combines x-ray and planar gamma scintigraphy, the research team demonstrated that the new genetic material was being expressed in the lungs of the mice, exactly where it was needed. When refined, this technique may prove useful for researchers testing novel gene delivery methods.

According to Dr. Zhenghong Lee, PhD, "Though the results are preliminary, they are extremely encouraging." The investigators will continue testing in their mice model systems and will work to translate these promising results to human patients once their preliminary studies are completed.

Cystic fibrosis is a fatal genetic pulmonary disease that causes abnormal mucus to accumulate in the lungs and digestive system. Affecting approximately 30,000 Americans, cystic fibrosis afflicts mostly children and, at one time, took its victims in their teens. Researchers have come a long way in treating the symptoms of disease, and this has allowed victims to live longer, but a cure has yet to be discovered.

The Society of Nuclear Medicine is holding its 51st Annual Meeting June 1923, 2004, at the Pennsylvania Convention Center in downtown
'"/>

Contact: Darren DiPatri
ddipatri@kamber.com
202-955-1242
Society of Nuclear Medicine
21-Jun-2004


Page: 1 2

Related biology news :

1. ASU researchers demonstrate new technique that improves the power of atomic force micrscopy
2. New technique helps scientists reveal interactions between genes and drugs
3. Researchers report major advance in gene therapy technique
4. Busy sequencing technique saves money and time
5. Laser technique used to build micro-polymeric structure on a human hair, without harming it
6. Better techniques needed to predict earthquake hazards, UC study finds
7. Scientists develop new cloning technique that dramatically shortens the search for genes
8. New imaging technique developed to identify breast cancer
9. Imaging technique reveals new structure in retinal cells
10. Statistical technique helps researchers gain more information from a single data run
11. Imaging technique discovered at Stanford monitors cancer cell proliferation

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/6/2019)... MEXICO CITY (PRWEB) , ... June 05, 2019 ... ... temperature-controlled packaging, announces the opening of a new network station and service center ... America — and 12th in the world — with more than $1.75 billion ...
(Date:6/4/2019)... ... June 04, 2019 , ... Most preclinical EEG ... seizure risk signals, usually based on variations of amplitude, frequency or spike train ... diagnostic methodology due to the complexity and variability of the signal, and automation ...
(Date:5/31/2019)... ... May 30, 2019 , ... ... and Mayo Clinic, have documented significant differences in the prevalence of hereditary genetic ... populations compared to non-Hispanic White women. Results will be presented at the 2019 ...
Breaking Biology News(10 mins):
(Date:6/6/2019)... ... June 05, 2019 , ... WCCT Global, Inc ... device industries, announced today that they will be receiving 3 awards at the 2019 ... WCCT received 2 awards in the categories of overall Quality and Compatibility (Access to ...
(Date:5/31/2019)... , ... May 30, 2019 , ... ... is pleased to announce the strategic acquisition of Metabiologics, Inc., a globally recognized ... provides Object exclusive ownership and commercialization rights to a full spectrum of botulinum ...
(Date:5/15/2019)... ... ... Milton Hershey School® has named William Charles Ballough Harding ’78 the 2019 ... he is changing lives by creating solutions to global healthcare challenges through the development ... our founders – Milton and Catherine Hershey – who always hoped for Milton Hershey ...
(Date:5/8/2019)... ... May 07, 2019 , ... Standing at 16.2 hands, Atlas is on the large side ... drill team and barrel racing, among other activities. When loping around a corner in ... from being a busy horse to only being able to walk. Fortunately Atlas’ owner, ...
Breaking Biology Technology:
Cached News: