HOME >> BIOLOGY >> NEWS
New test for radiation damage to DNA developed at Brookhaven Lab

UPTON, NY -- In research that could help assess the radiation risks faced by astronauts, improve the cancer-killing potential of radiation therapy, and distinguish between DNA damage caused by normal living and that caused by low-level radiation, scientists at the U.S. Department of Energy's Brookhaven National Laboratory have developed a new way to detect and quantify varieties of radiation damage that previously could not be measured.

Scientists have long known that ionizing radiation, such as gamma rays and x-rays, can damage deoxyribonucleic acid (DNA), the genetic-code-carrying molecule that tells cells which proteins to make. The oxygen we breathe can cause damage, too. Most of the time, our bodies repair the damage we receive from everyday radiation sources such as sunlight and from oxygen. But unrepaired or incorrectly repaired damage can be lethal to cells or cause cancer.

"For years, people have been worried about the consequences of double strand breaks," says Betsy Sutherland, who leads the Brookhaven research team. These closely spaced breaks through both strands of the DNA double helix are known to be difficult for cells to repair. Scientists have also hypothesized that radiation might produce other forms of clustered damage on both DNA strands, like oxidation of the bases A, G, C, and T. Could these clustered damage sites be equally, or more, harmful? The problem with finding out, Sutherland says, is that no one has had a way to determine if radiation actually induces these kinds of damage, or to measure their frequencies and assess their repairability -- until now.

"We figured out how to do it," Sutherland says. The idea is fairly simple: Sutherland and her team use special enzymes supplied by collaborators in France that are designed to cut DNA strands at sites of specific kinds of damage. The team first irradiates the DNA (or cells in culture), then chops the DNA with the enzymes, and finally separates and counts the fragments on e
'"/>

Contact: Karen McNulty
kmcnulty@bnl.gov
631-344-8350
DOE/Brookhaven National Laboratory
10-Jul-2000


Page: 1 2

Related biology news :

1. New evidence of radiation risk in childhood leukaemia
2. Chernobyl study: Risk of thyroid cancer rises with radiation dose
3. Many physicians misperceive radiation risks to developing fetuses from X-rays and CT scans
4. New insight into how tumors resist radiation
5. Ultraviolet irradiation in ventilation systems could reduce office sickness
6. Diet may improve cognition, slow aging, and help protect against cosmic radiation
7. Study explores safety of low-dose radiation
8. UMHS researchers find clues to growing new jawbones in cancer patients after radiation therapy
9. New NASA facility will help protect space crews from radiation
10. A test for sensitivity of normal tissue to radiation damage?
11. Finding dirty bombs and other radiation threats

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/10/2020)... ... July 09, 2020 , ... Today CJ BIO announced the first ... insight on the “fifth taste” phenomenon that is revolutionizing ingredient mixes, nutritional content and ... be live on Monday, July 13, 2020 at11:00 AM (CDT) during SHIFT20, the virtual ...
(Date:7/2/2020)... ... July 01, 2020 , ... AltruBio Inc. http://www.altrubio.com ... a biologic for the treatment of steroid-refractory acute graft-versus-host disease (SR-aGVHD), at European ... J Martin of the Fred Hutchinson Cancer Research Center, this single-arm, open-label Phase ...
(Date:7/1/2020)... ... 2020 , ... Catalent, a global leader in clinical supply ... facility in Minakuchi, located in the Shiga prefecture of Japan. , Operating in ... new 60,000-square-foot facility will provide customers with flexible clinical supply solutions, serving both ...
Breaking Biology News(10 mins):
(Date:8/31/2020)... WILMINGTON, Del. (PRWEB) , ... August 29, 2020 ... ... of a new Animal Nutrition manufacturing capability in Wuxi, China. The new plant ... DuPont’s global quality standards and advanced technology. , “This facility will improve ...
(Date:8/12/2020)... ... August 11, 2020 , ... The FSHD ... Facioscapulohumeral Muscular Dystrophy Clinical Trial Research Network (FSHD CTRN), with consideration ... is a consortium of academic research centers in the United States and Europe ...
(Date:8/7/2020)... ... August 06, 2020 , ... VGXI, a highly regarded CDMO ... the purchase of greenfield for a new, expanded manufacturing facility. The site is ... in the initial acquisition, with an option to purchase an additional 21 acres ...
(Date:7/31/2020)... ... July 29, 2020 , ... R3 Stem Cell International ... only $3950. With 50 million stem cells total, patients may choose which extremities they ... works for arthritic joints (BMC Musculoskelet Disord. 2016). At R3 International, umbilical cord tissue ...
Breaking Biology Technology:
Cached News: