HOME >> BIOLOGY >> NEWS
New test for radiation damage to DNA developed at Brookhaven Lab

lectrophoretic gels to measure the levels of clusters containing each kind of damage.

The data they've collected so far, both from DNA in solution and from human cell cultures, indicate that radiation does induce clusters of damage such as oxidized DNA bases and so-called abasic sites, where the base is simply knocked off the DNA sugar backbone. Surprisingly, says Sutherland, these other forms of clusters comprise some 80 percent of the complex damage sites observed , with double strand breaks comprising only 20 percent.

"This means that the effects of most types of complex DNA damage in the cells and how they are repaired are completely unknown. The only way to find out about them is to make careful measurements -- and we have a way to do that now," Sutherland says.

The team is currently irradiating cells, measuring various kinds of clustered damage, and assessing how rapidly the cells remove and repair the different forms of damage. Scientists could also use the technique to see if all cells in the body respond the same way, and if there are differences in susceptibility to certain kinds of damage among species, or among different people.

The findings could indicate whether certain people might run a greater risk of radiation damage during long-term missions to Mars or on the Space Station. The National Aeronautics and Space Administration (NASA) estimates that DNA in one-third of astronauts' cells will be hit directly by a heavy charged particle during each year in space. The studies could also help assess the potential of antioxidants to counteract DNA damage, or reveal ways to use radiation more effectively in fighting cancer. "We hope that if we learn how to alter damage to tumor cells, we can improve therapeutic regimens," Sutherland says.


'"/>

Contact: Karen McNulty
kmcnulty@bnl.gov
631-344-8350
DOE/Brookhaven National Laboratory
10-Jul-2000


Page: 1 2

Related biology news :

1. New evidence of radiation risk in childhood leukaemia
2. Chernobyl study: Risk of thyroid cancer rises with radiation dose
3. Many physicians misperceive radiation risks to developing fetuses from X-rays and CT scans
4. New insight into how tumors resist radiation
5. Ultraviolet irradiation in ventilation systems could reduce office sickness
6. Diet may improve cognition, slow aging, and help protect against cosmic radiation
7. Study explores safety of low-dose radiation
8. UMHS researchers find clues to growing new jawbones in cancer patients after radiation therapy
9. New NASA facility will help protect space crews from radiation
10. A test for sensitivity of normal tissue to radiation damage?
11. Finding dirty bombs and other radiation threats

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/27/2021)... ... March 25, 2021 , ... Phlexglobal announced ... Planet Group, has selected Phlexglobal and its innovative regulatory SaaS software, PhlexSubmission, as ... a comprehensive review of five regulatory software companies, with the review team including ...
(Date:3/27/2021)... ... 25, 2021 , ... The 2021 Virtual Conference on Clinical Trial Supply-Europe ... More and more, clinical trial supply conferences are featuring speakers and forums that ... Asymmetrex’s founder and CEO, James L. Sherley, M.D., Ph.D., presented a talk ...
(Date:3/23/2021)... ... March 23, 2021 , ... G-CON Manufacturing (G-CON), the ... by Matica Biotechnology (Matica Bio), a contract development and manufacturing organization (CDMO) specializing ... the cleanroom build out for its new GMP production facility in College Station, ...
Breaking Biology News(10 mins):
(Date:3/27/2021)... ... March 24, 2021 , ... ... Life Sciences and Healthcare firms of all sizes, adds depth to its team ... specialist. Pardillo, who earned his doctorate in computational chemistry from Florida International University ...
(Date:3/27/2021)... ... March 24, 2021 , ... ABI Wellness, ... and reporting approach designed under CEO Mark Watson, today announced a webinar dedicated ... featuring guest speakers Dr. Cameron Clark, Neuropsychologist and Founder of Sharp Thinking, and ...
(Date:3/27/2021)... ... ... The Xtalks editorial team is pleased to announce the launch of the ... joined by editorial team members Ayesha Rashid, Sydney Perelmutter and Mira Nabulsi to discuss ... including insights from industry experts. , The Xtalks Life Science podcast will feature ...
(Date:3/23/2021)... Conn. (PRWEB) , ... March 23, 2021 , ... ... develops solutions for characterizing microbiome populations down to the strain level, recently unveiled ... applications. , Not all microbes are created equal: some are easy to ...
Breaking Biology Technology:
Cached News: