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New test offers hope of easy and affordable screening for hereditary breast cancer genes

n two tumours from the same family, then this indicates the presence of a mutated breast cancer predisposition gene.

This is an easy and affordable procedure which may be useful as a screening tool in at-risk families. More families could benefit from genetic testing because LOH reduces costs by eliminating unnecessary genetic mutational analyses; it also has the potential to halve the cost of mutational analyses because it can indicate whether the BRCA1 or BRCA2 gene is mutated, and therefore only one gene needs to be tested for. In families where mutational analysis is not possible at the moment because they have no alive, affected relative, women can have LOH and risk taking decisions based on the results of LOH alone.

LOH testing may also find an application in the search for other possible breast cancer genes. As scientists discover genetic regions where there may be potential breast cancer predisposition genes, LOH testing (by using markers near these regions of interest) would help in identifying these genes.


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Contact: Emma Mason
wordmason@aol.com
+44-0-7711-296-986
Federation of European Cancer Societies
20-Mar-2002


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