New view of evolving genes, proteins to aid bioinformatics

Rockville, MD -- Today's evolutionary theory is not enough to tell us how even simple mutation biases may skew the evolutionary process, according to a report by scientists from the University of Maryland Biotechnology Institute (UMBI).

In the March edition of the journal Evolution and Development, research associate Lev Yampolsky and research biologist Arlin Stoltzfus of UMBI's Center for Advanced Research in Biotechnology (CARB) make a case that simple biases in mutation will change the evolutionary process. They use mathematics and computer simulations to explore the role of mutation biases using the classic "Bateson-Dobzhansky-Muller" model.

"Recognizing this kind of bias as an evolutionary cause will increase our ability to explain and predict evolution, and will aid researchers as they seek to understand such things as the amino acid composition of proteins, the appearance of new strains of viruses strains, and the distribution of introns in genes, all of which exhibit components of change that suggest a role of biases in the process of mutation," explains Stoltzfus. (Introns are DNA sequences in genes that don't encode proteins, thus having no defined purpose.)

The CARB study also helps to make more sense of the results of the rapidly growing science of bioinformatics, the data analysis of genomes and proteins. Since the 1970's when the technique of gene sequencing was developed, evidence has been accumulating that mutation biases strongly influence the evolution of genes and proteins, say the authors. The influence has been interpreted as a sign of "neutral evolution", a kind of random noise in the evolutionary process.

But now Yampolsky and Stoltzfus argue that in a more general theory, mutation-biased evolution does not have to be neutral.

In historic perspective, the new paper shows that it is still possible to stake out a new position on an old issue in evolutionary theory. Charles Darwin and other 19th century scientists realiz

Contact: Steve Berberich
University of Maryland Biotechnology Institute

Page: 1 2

Related biology news :

1. Technique plucks rapidly evolving genes from a pathogens genome
2. Rapidly evolving genes providing new insights in plant evolution
3. In mutually beneficial relationship, slowest-evolving species gains upper hand
4. University of Cincinnati geologist finds survival benefit to evolving after mass extinctions
5. Therapy hinders AIDS virus from evolving drug resistance, Hopkins researchers find
6. Rapid size change in introduced fruit fly indicates it is evolving as it invades North America
7. Tracing genes, biologists show lizard migration is traced to Florida
8. Access to DNA secrets yields better understanding of genes, possible tool for disease diagnosis
9. Heart may heal with help from oxygen-sensitive genes, new study suggests
10. Family history doesnt predict colon cancer genes, behavior
11. Modified zebrafish may point the way toward T cell leukemia genes, aid in drug development

Post Your Comments:

(Date:10/29/2015)... , Oct. 29, 2015 Today, ... announced a partnership with 2XU, a global leader ... deliver a smart hat with advanced bio-sensing technology. ... other athletes to monitor key biometrics to improve ... strategic partnership, the two companies will bring together the ...
(Date:10/27/2015)... 2015 Munich, Germany ... technology (ASGM) automatically maps data from mobile eye tracking ... , so that they can be quantitatively analyzed with ... Munich, Germany , October 28-29, 2015. SMI,s Automated ... mobile eye tracking videos created with SMI,s Eye ...
(Date:10/26/2015)... , October 26, 2015 ... --> ReportnsReports.com adds Biometrics Market ... 2021 as well as Emerging Biometrics ... reports to its collection of IT ... . --> http://www.reportsnreports.com/reports/427352-biometrics-market-shares-market-strategies-and-market-forecasts-2015-to-2021.html ...
Breaking Biology News(10 mins):
(Date:11/25/2015)... Nov. 25, 2015  PharmAthene, Inc. (NYSE MKT: PIP) ... a stockholder rights plan (Rights Plan) in an effort ... carryforwards (NOLs) under Section 382 of the Internal Revenue ... PharmAthene,s use of its NOLs could be substantially ... defined in Section 382 of the Code. In general, ...
(Date:11/25/2015)... /PRNewswire/ - Aeterna Zentaris Inc. (NASDAQ:  AEZS; TSX: AEZ) ... remain fundamentally strong and highlights the following developments: ... DSMB recommendation to continue the ZoptEC Phase 3 ... final interim efficacy and safety data , ... with heavily pretreated castration- and Taxane-resistant prostate cancer ...
(Date:11/24/2015)... 24, 2015  Asia-Pacific (APAC) holds the third-largest ... market. The trend of outsourcing to low-cost locations ... higher volume share for the region in the ... margins in the CRO industry will improve. ... ( http://www.frost.com/sublib/display-report.do?id=P86A-01-00-00-00&src=PR ), finds that the market earned ...
(Date:11/24/2015)... ... 2015 , ... Copper is an essential micronutrient that all ... copper is also toxic to cells. With a $1.3 million award from the ... a systematic study of copper in the bacteria Pseudomonas aeruginosa (P. aeruginosa), a ...
Breaking Biology Technology:
Cached News: