HOME >> BIOLOGY >> NEWS
New way to lock DNA-slicing enzyme onto chromosomes could lead to novel anti-cancer drugs

Investigators at St. Jude Children's Research Hospital have discovered a new way that an enzyme crucial to the cell's ability to decode genes and duplicate chromosomes can be turned into a poison inside cancer cells.

The discovery is an important step toward designing a new class of anti-cancer drugs. Such drugs might be given with an existing agent that also targets this enzyme, creating a one-two punch against both solid tumors and leukemia, according to the researchers.

The enzyme, called Topoisomerase 1 (Top 1), is crucial to the cell's ability to unwind the DNA of chromosomes and separate the two strands making up a giant molecule. This activity permits the cell to transcribe (decode) specific genes or to make a copy of the entire chromosome. Duplication of chromosomes is critical to the process called mitosis, or cell division. After the cell divides, each daughter cell receives a copy of the entire set of duplicated chromosomes.

"We showed that modifying Top 1 so it became locked onto the DNA molecule is enough to cause cell death," said Mary-Ann Bjornsti, Ph.D., associate member of the St. Jude Molecular Pharmacology department. Bjornsti is the senior author of a report on this work, published in the November 25 issue of Proceedings of the National Academy of Sciences.

In order to begin unraveling the double-stranded DNA molecule, Top 1 first clamps onto the spiraled DNA molecule like a pair of C-shaped pliers grasping a twisted cable. Top 1 then breaks a chemical bond between two adjacent building blocks of one DNA strand and uses that bond to bind itself to one of the cut ends of that strand. This process allows the DNA next to Top 1 to rotate and reduce some of the tension in that part of the twisted molecule. This in turn paves the way for other enzymes to unravel the DNA and either decode a specific gene or duplicate the entire chromosome. Normally, Top 1 moves along the DNA, clipping the strand as it goes, while the o
'"/>

Contact: Bonnie Cameron
bonnie.cameron@stjude.org
901-495-4815
St. Jude Children's Research Hospital
12-Dec-2003


Page: 1 2

Related biology news :

1. Anthrax enzyme images reveal secrets of antibiotic resistance, suggest new drug design
2. First glimpse of DNA binding to viral enzyme
3. Two enzymes key to calorie-burning, Brown research shows
4. Argonne scientists determine structure of staph, anthrax enzyme
5. Brain serotonin enzyme finding might explain psychiatric disorders
6. Study finds plant enzyme function changes with location in cell
7. Basic RNA enzyme research promises single-molecule biosensors
8. Molecule that blocks key bacterial enzyme may lead to new antibiotics
9. Study finds first evidence COX-2 enzymes can regulate DNA damage
10. UNC scientists block cellular enzyme activity involved in cancer progression
11. ADAM: Good enzyme for Alzheimer disease

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/23/2020)... ... June 23, 2020 , ... ... monoclonal antibody development services, today announced that the company has received ISO9001:2015 ... the pharmaceutical, diagnostics, and research industries. The decision to pursue ISO9001 accreditation ...
(Date:6/23/2020)... ... , ... In its June 22 online post, business and technology news platform ... Ph.D., founder and director of stem cell biotechnology company Asymmetrex . Superb Crew ... starting July 5 it would begin offering free tissue stem cell counting ...
(Date:6/13/2020)... ... June 11, 2020 , ... Bode Technology (Bode), ... forensic genealogy team. Bode’s Forensic Genealogy Service (FGS) continues to deliver ... analysis methods. The team has added experienced genealogists, each having over a decade ...
Breaking Biology News(10 mins):
(Date:6/28/2020)... ROCKY HILL, Conn. (PRWEB) , ... June 25, ... ... systems company formed to advance photodynamic therapy for treating cancer, today announced the ... Buffalo, New York (“Roswell Park”). The agreement provides Lumeda globally exclusive rights ...
(Date:6/23/2020)... ... , ... Kerafast Inc. , developers of an online ... of the Delta-G-VSV Pseudotyping System for coronavirus research applications. The system, developed by ... entry and COVID-19 vaccine effectiveness at just biosafety level 2 (BSL-2) containment. , ...
(Date:6/23/2020)... ... 2020 , ... Regen Suppliers, the one stop shop for ... get the fourth unit free with no limit on the amniotic derived exosomes. ... have been a game changer for regenerative therapies. The products are manufactured at ...
(Date:6/23/2020)... ... June 23, 2020 , ... ... therapies, today announced that it has filed an Investigational New Drug application (IND) ... clinical trial of its lead drug candidate NBTX-001 in patients with panic disorder ...
Breaking Biology Technology:
Cached News: