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New way to protect brain from stroke damage

nical efforts to prevent brain injury through the therapeutic use of NMDA receptor antagonists have been disappointing," they wrote.

The new study pinpoints a new target underlying toxic levels of calcium in the brain, disclosing a potential new therapeutic target for stroke, the researchers added. Blockers of ASIC1a, either alone or in concert with other neuroprotective methods, might therefore prove useful for stroke therapy, they said.

Zhi-Gang Xiong, Xiao-Man Zhu, Xiang-Ping Chu, Manabu Minami, Jessica Hey, Wen-Li Wei, John F. MacDonald, John A Wemmie, Margaret P Price, Michael J Welsh, and Roger P. Simon: "Neuroprotection in Ischemia: Blocking Calcium-Permeable Acid-Sensing Ion Channels"


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Contact: Heidi Hardman
hhardman@cell.com
617-397-2879
Cell Press
16-Sep-2004


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