HOME >> BIOLOGY >> NEWS
Newly Discovered Gene Halts Cell Division and May Have Cancer Link

NEW YORK, Oct. 11, 1996 -- Scientists at Memorial Sloan-Kettering Cancer Center have identified a human gene that arrests cell division in the laboratory and, when defective, may lead to the development of cancer. They reported the finding in the Oct. 11 issue of the journal Science.

The study suggests that if the gene's activity is blocked, cell division continues haphazardly and can lead to the formation of new cells that are missing chromosomes -- an event that is notoriously linked to tumor growth.

The researchers suspect that certain genetically unstable breast, ovarian, and prostate tumors may have defects in the gene, known as MAD2. The new discovery may open the door to finding more effective ways to treat such tumors.

"We think the MAD2 gene stops cells from dividing when doing so would leave the newly formed daughter cells without all the chromosomes they need to function properly," says Dr. Robert Benezra, an investigator in the Cell Biology and Genetics Program at Memorial Sloan-Kettering and the study's lead author.

MAD2 is the first human gene to be identified that serves as a checkpoint for cells to progress into the final stages of cell division. Until now, the only other checkpoint gene to be discovered was p53, which allows a cell to copy its DNA at an earlier phase in the cell cycle. Defects in the p53 gene are known to be involved in about half of all tumors.

The MAD2 gene allows a cell to commit to divide only after the gene checks to ensure that chromosomes, which contain DNA's genetic blueprint, are ready to separate normally to form two genetically identical cells.

"If MAD2 is defective and the checkpoint is challenged -- either by drugs or environmental stresses -- cell division can continue out of control and leave some new cells without a copy of each chromosome, which can lead to cancer," Dr. Benezra says.

The MAD2 checkpoint appears to plays an esse
'"/>

Contact: Chris Westerman
westermac@mskcc.org
212-639-3576
Memorial Sloan-Kettering Cancer Center
11-Oct-1996


Page: 1 2 3

Related biology news :

1. Newly identified master gene key in babys first breath
2. Newly discovered protein may be key to muscular dystrophy
3. Newly designed nanoparticle quantum dots simultaneously target and image prostate tumors in mice
4. Newly grown kidneys can sustain life in rats
5. Newly discovered gene controls levels of bad cholesterol in mice
6. Newly identified gene linked to brain development
7. Newly cloned gene key to global adaptation of wheat
8. Newly identified genes may help predict outcome in childhood leukemia
9. Newly identified gene may halt fuzzy, moldy fruit
10. Newly found gene resistant to economically crippling wheat disease
11. Newly invented Endometrial Function Test (EFT®) solves the puzzle of unexplained infertility

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/27/2021)... ... March 25, 2021 , ... Phlexglobal announced ... Planet Group, has selected Phlexglobal and its innovative regulatory SaaS software, PhlexSubmission, as ... a comprehensive review of five regulatory software companies, with the review team including ...
(Date:3/27/2021)... ... 25, 2021 , ... The 2021 Virtual Conference on Clinical Trial Supply-Europe ... More and more, clinical trial supply conferences are featuring speakers and forums that ... Asymmetrex’s founder and CEO, James L. Sherley, M.D., Ph.D., presented a talk ...
(Date:3/23/2021)... ... March 23, 2021 , ... G-CON Manufacturing (G-CON), the ... by Matica Biotechnology (Matica Bio), a contract development and manufacturing organization (CDMO) specializing ... the cleanroom build out for its new GMP production facility in College Station, ...
Breaking Biology News(10 mins):
(Date:3/27/2021)... ... March 24, 2021 , ... ... Life Sciences and Healthcare firms of all sizes, adds depth to its team ... specialist. Pardillo, who earned his doctorate in computational chemistry from Florida International University ...
(Date:3/27/2021)... ... March 24, 2021 , ... ABI Wellness, ... and reporting approach designed under CEO Mark Watson, today announced a webinar dedicated ... featuring guest speakers Dr. Cameron Clark, Neuropsychologist and Founder of Sharp Thinking, and ...
(Date:3/27/2021)... ... ... The Xtalks editorial team is pleased to announce the launch of the ... joined by editorial team members Ayesha Rashid, Sydney Perelmutter and Mira Nabulsi to discuss ... including insights from industry experts. , The Xtalks Life Science podcast will feature ...
(Date:3/23/2021)... Conn. (PRWEB) , ... March 23, 2021 , ... ... develops solutions for characterizing microbiome populations down to the strain level, recently unveiled ... applications. , Not all microbes are created equal: some are easy to ...
Breaking Biology Technology:
Cached News: