HOME >> BIOLOGY >> NEWS
Newly Discovered Gene Halts Cell Division and May Have Cancer Link

ntial role in the cell cycle, Dr. Benezra says. After a cell's DNA is copied, each pair of the duplicated chromosomes is bound together at structures, called centromeres, that fit around each chromosome like a napkin ring. In order for a cell to divide, thread-like fibers must attach to each centromere and pull the chromosomes apart. That's where the MAD2 gene comes in.

The research suggests that MAD2 produces a protein that sits at the centromere of each chromosome and waits for the thread-like fibers to attach. If the fibers attach properly, cell division proceeds and each new cell gets a complete copy of the genetic blueprint of the original cell. But if the fibers fail to anchor to one of the centromeres, the corresponding chromosome pair can't separate normally and MAD2 puts the brakes on cell division.

Dr. Benezra speculates that MAD2 is only one of several genes involved in triggering this cell division checkpoint. In yeast, for example, six genes are known to exert their control over the checkpoint. Dr. Benezra, whose team discovered the MAD2 gene by accident, also is investigating a second human gene suspected of being involved in the checkpoint.

The new research may help to improve future treatment options for cancer patients. In the study, the researchers identified a human breast tumor cell line that is sensitive to the cancer drugs taxol and nocodazole. The drugs, called spindle inhibitors, block the formation of the thread-like fibers that pull chromosomes apart during cell division.

After the researchers treated the breast tumor cell line with nocodazole, the cells continued to undergo cell division, which suggests the cells may be defective in the checkpoint. When the investigators looked further, they confirmed their suspicion -- the cell line had low levels of MAD2 expression compared to control cells that were resistant to both drugs.

The drugs may be especially effective in the treatment of tumors with a defective checkpoint,
'"/>

Contact: Chris Westerman
westermac@mskcc.org
212-639-3576
Memorial Sloan-Kettering Cancer Center
11-Oct-1996


Page: 1 2 3

Related biology news :

1. Newly identified master gene key in babys first breath
2. Newly discovered protein may be key to muscular dystrophy
3. Newly designed nanoparticle quantum dots simultaneously target and image prostate tumors in mice
4. Newly grown kidneys can sustain life in rats
5. Newly discovered gene controls levels of bad cholesterol in mice
6. Newly identified gene linked to brain development
7. Newly cloned gene key to global adaptation of wheat
8. Newly identified genes may help predict outcome in childhood leukemia
9. Newly identified gene may halt fuzzy, moldy fruit
10. Newly found gene resistant to economically crippling wheat disease
11. Newly invented Endometrial Function Test (EFT®) solves the puzzle of unexplained infertility

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Newly Discovered Gene Halts Cell Division and May Have Cancer Link

(Date:8/26/2015)... , August 26, 2015 The ... and Five Factor), Application (Travel & Immigration, Government, Banking, ... Global Forecast to 2020", published by MarketsandMarkets, Multi-Factor Authentication ... 2020, growing at a CAGR of 17.7% between 2015 ... 82 F igures spread through 169 ...
(Date:8/25/2015)... LAKE CITY and BELLEVUE, Wash. ... global leader in advanced robotic systems, announced today it ... robotic unmanned ground vehicle (UGV), at the National Tactical ... City.  The Guardian S is the ... the culmination of years of research and in-field trials ...
(Date:8/24/2015)... TOWN, South Africa , August 24, 2015 ... Germany ,s largest biometrics manufacturer DERMALOG and ... with the "2015 African Biometrics Company of the Year ... in Nigeria .   -Cross ... and http://www.presseportal.de/nr/8896 - On Thursday evening, ...
Breaking Biology News(10 mins):Multi-Factor Authentication Market Worth 9.60 Billion USD by 2020 2Multi-Factor Authentication Market Worth 9.60 Billion USD by 2020 3Multi-Factor Authentication Market Worth 9.60 Billion USD by 2020 4Multi-Factor Authentication Market Worth 9.60 Billion USD by 2020 5Sarcos to Debut First-of-its-Kind Snake Robot 2Sarcos to Debut First-of-its-Kind Snake Robot 3Frost & Sullivan Honors DERMALOG with Biometrics Prize for Achievements in Africa 2Frost & Sullivan Honors DERMALOG with Biometrics Prize for Achievements in Africa 3
(Date:8/26/2015)... ... 26, 2015 , ... Lee Biosolutions, a global biotech healthcare ... of highly valued cardiac markers used in early detection of heart disease due ... has led to the development and commercialization of important cardiac biomarkers used in ...
(Date:8/26/2015)... GERMANTOWN, Md. , Aug. 26, 2015 ... synthetic biology, announced today the closing of its previously ... in full by the underwriters of their option to ... the public offering price of $41.00 per share.  The ... of shares of common stock sold by Intrexon to ...
(Date:8/26/2015)... , August 26, 2015 After litigating ... Europlasma NV relating to P2i United States ... their dispute in the United States ... the part of either party. As a result of the ... of California dismissed the case without ...
(Date:8/26/2015)... ... 26, 2015 , ... The 2015 Epigenomics & Metabolomics Meeting in ... Asymmetrex to share the first report on progress with its crowdsourcing campaign ... adult tissue stem cells. , With a name like “H2A.Z asymmetry,” the new biomarker ...
Breaking Biology Technology:Lee Biosolutions Announces Increased Investment in the Development and Manufacturing of Biomarkers Used in Early Detection Of Heart Disease 2Intrexon Announces Closing of $230 Million Public Offering of Common Stock including Full Exercise of Underwriters' Option to Purchase Additional Shares 2Intrexon Announces Closing of $230 Million Public Offering of Common Stock including Full Exercise of Underwriters' Option to Purchase Additional Shares 3Intrexon Announces Closing of $230 Million Public Offering of Common Stock including Full Exercise of Underwriters' Option to Purchase Additional Shares 4P2i Settles United States Litigation 2Asymmetrex Reports Positive Indicators for Crowdsourcing Campaign to Evaluate New Biomarker for Counting Adult Tissue Stem Cells for the First Time 2Asymmetrex Reports Positive Indicators for Crowdsourcing Campaign to Evaluate New Biomarker for Counting Adult Tissue Stem Cells for the First Time 3Asymmetrex Reports Positive Indicators for Crowdsourcing Campaign to Evaluate New Biomarker for Counting Adult Tissue Stem Cells for the First Time 4
Cached News: