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Newly Discovered Human Protein Provides Important Target For Cancer Therapy

criptase enzyme produced by the HIV virus that causes AIDS. Several of the most commonly used AIDS drugs, including AZT, are reverse transcriptase inhibitors.

"The beauty of this finding is that we already know a great deal about the structure of reverse transcriptase inhibitors," Dr. Counter says. "We have a good starting point for developing anti-telomerase drugs."

This work was supported in part by the National Cancer Institute of the United States, the National Cancer Institute of Canada, the Damon Runyon-Walter Winchell Cancer Research Foundation, the MIT-Merck Postdoctoral Fellowships Program, the Howard Hughes Medical Institute, and the Human Frontier Science Program. Dr. Weinberg is a founding Member of the Whitehead Institute for Biomedical Research, an American Cancer Society Research Professor, and the Daniel K. Ludwig Cancer Research Professor at MIT. Drs. Meyerson and Counter are post-doctoral fellows in the Weinberg lab.


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Contact: Eve Nichols or Seema Kumar
Nichols@wi.mit.edu
(617) 258-5183
Whitehead Institute for Biomedical Research
14-Aug-1997


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