HOME >> BIOLOGY >> NEWS
Newly Identified Molecular Mechanism Could Lead To New Approaches For Preventing,,Heart Attack, Stroke

UC San Francisco researchers have identified a molecular mechanism that may play an important role in activating platelets, the blood cells that coagulate to stop bleeding but also cause the clots leading to heart attack and stroke. The finding, published in the August 13 issue of Nature, requires further investigation, said the senior author of the study, Shaun R. Coughlin, MD, PhD, director of the Cardiovascular Research Institute (CRVI) and professor of medicine and cellular and molecular pharmacology at UCSF, but it could provide a new avenue for developing drugs for preventing heart attack and stroke.

The study, conducted in mice and on human platelets, explored the way in which the enzyme known as thrombin, one of several factors known to activate platelets, stimulates the blood cells into action. The initial observations in mice led the researchers to a potentially profound finding for humans.

In the mouse study, the researchers determined that thrombin is able to activate platelets by latching onto, and cleaving, a newly identified receptor in the membrane of the cells. When the enzyme (a protease) binds to the receptor, it instigates the transmembrane signaling that prompts platelet aggregation. The researchers named the receptor protease activated receptor (PAR) 4.

The investigators had previously identified a PAR in human platelets, which they named PAR1. They also had previously identified a PAR in mouse platelets, which they named PAR3.

In the current study, they created a mouse model with platelets lacking PAR3 and found that while the mice had a markedly delayed and diminished response to thrombin activation the response was not totally absent. The discovery of PAR4 explained the continued response. "We determined that PAR3 is necessary for normal thrombin responses in mouse platelets, but that PAR4 does contribute to thrombin signaling," said Coughlin.

The discovery that PAR3 and PAR4 appear to act as a dual-receptor syst
'"/>

Contact: Jennifer O'Brien
jobrien@itsa.ucsf.edu
(415) 476-2557
University of California - San Francisco
12-Aug-1998


Page: 1 2 3

Related biology news :

1. Newly identified master gene key in babys first breath
2. Newly discovered protein may be key to muscular dystrophy
3. Newly designed nanoparticle quantum dots simultaneously target and image prostate tumors in mice
4. Newly grown kidneys can sustain life in rats
5. Newly discovered gene controls levels of bad cholesterol in mice
6. Newly identified gene linked to brain development
7. Newly cloned gene key to global adaptation of wheat
8. Newly identified genes may help predict outcome in childhood leukemia
9. Newly identified gene may halt fuzzy, moldy fruit
10. Newly found gene resistant to economically crippling wheat disease
11. Newly invented Endometrial Function Test (EFT®) solves the puzzle of unexplained infertility

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/14/2017)... (NYSE: IBM ) is introducing several innovative partner startups ... collaboration between startups and global businesses, taking place in ... nine startups will showcase the solutions they have built with ... France is one of the ... percent increase in the number of startups created between 2012 ...
(Date:5/16/2017)... 16, 2017   Bridge Patient Portal , ... MD EMR Systems , an electronic medical ... GE, have established a partnership to build an ... the GE Centricity™ products, including Centricity Practice Solution ... These new integrations will allow healthcare delivery ...
(Date:4/19/2017)... New York , April 19, 2017 ... competitive, as its vendor landscape is marked by the ... the market is however held by five major players ... Safran. Together these companies accounted for nearly 61% of ... of the leading companies in the global military biometrics ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... October 12, 2017 , ... ... platform specifically designed for life science researchers to analyze and interpret datasets, ... Franklin, who made a major contribution to the discovery of the double-helix ...
(Date:10/11/2017)... ... ... Personal eye wash is a basic first aid supply for any work environment, but most ... you rinse first if a dangerous substance enters both eyes? It’s one less decision, and ... unique dual eye piece. , “Whether its dirt and debris, or an acid or alkali, ...
(Date:10/11/2017)... , Oct. 11, 2017  VMS BioMarketing, a leading ... a nationwide oncology Clinical Nurse Educator (CNE) network, which will ... need for communication among health care professionals to enhance the ... nurses, office staff, and other health care professionals to help ... breast cancer. ...
(Date:10/11/2017)... ... October 11, 2017 , ... ... implantation and pregnancy rates in frozen and fresh in vitro fertilization (IVF) ... and maternal age to IVF success. , After comparing the results from the ...
Breaking Biology Technology:
Cached News: