HOME >> BIOLOGY >> NEWS
Newly grown kidneys can sustain life in rats

and 6-week-old rats. Prior to insertion, scientists soaked the transplant tissue in a solution that included several human growth factors, proteins and hormones. One of the rats' original kidneys was removed at the same time.

Three weeks after the transplant, researchers connected the new kidneys to the bladder and administered a second dose of growth factors.

Approximately five months after the transplants, scientists removed the remaining original kidney in control and experimental rats. To help resolve uncertainty about which kidney functions are critical to sustaining life, scientists cut the connections between the bladder and the new kidneys in a subset of the experimental rats.

Rats with no new kidneys lived for two to three days, and rats whose new kidneys were disconnected from their bladders lived no longer. However, the rats with new kidneys connected to their bladders lived seven to eight days.

"This tells us that the urine-producing functions of the kidney are key to preservation of life," says Rogers.

"Seven to eight days may not seem like a long time," adds Hammerman. "However, what we have done is akin to building the first airplane and showing that it can fly, if only for a few minutes. It's just as revolutionary."

In this study and in other previous research, Hammerman and Rogers have established that the newly grown kidneys can perform many essential renal functions.

"For example, we've shown that they can excrete inulin, an inert sugar that we inject into a rat's bloodstream," Hammerman says. "This demonstrates that the kidneys are filtering the blood."

When scientists injected the rats with another compound known as p-aminohippurate, the kidney began to secrete it into the urine.

In addition to excretion and filtration, the new kidney also has to reabsorb salts, water and key nutrients. The researchers have shown that the new kidneys can reabsorb both water and the nutrie
'"/>

Contact: Michael C. Purdy
purdym@wustl.edu
314-286-0122
Washington University School of Medicine
21-Jun-2004


Page: 1 2 3 4

Related biology news :

1. Newly identified master gene key in babys first breath
2. Newly discovered protein may be key to muscular dystrophy
3. Newly designed nanoparticle quantum dots simultaneously target and image prostate tumors in mice
4. Newly discovered gene controls levels of bad cholesterol in mice
5. Newly identified gene linked to brain development
6. Newly cloned gene key to global adaptation of wheat
7. Newly identified genes may help predict outcome in childhood leukemia
8. Newly identified gene may halt fuzzy, moldy fruit
9. Newly found gene resistant to economically crippling wheat disease
10. Newly invented Endometrial Function Test (EFT®) solves the puzzle of unexplained infertility
11. Newly mapped enzyme could yield new treatments for female sexual dysfunction

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/22/2020)... (PRWEB) , ... April 21, 2020 , ... Worcester Polytechnic ... to help provide critical medical supplies to address the expected spike of COVID-19 cases. ... ) initiative, WPI has arranged for 3D printers and other materials to be sent ...
(Date:4/18/2020)... , ... April 17, 2020 ... ... miniature lab device that uses magnetic nano-beads to isolate minute bacterial particles ... strains of bacterial infections and difficult-to-detect micro-particles such as those making up ...
(Date:4/16/2020)... ... April 15, 2020 , ... RoosterBio Inc., a leading ... systems, announces that the Medical Technology Enterprise Consortium (MTEC) recognized a multi-institution team ... in March. The Regenerative Medicine (RegenMed) biomanufacturing collaboration had created a team initiative ...
Breaking Biology News(10 mins):
(Date:5/14/2020)... ... May 13, 2020 , ... Early stages ... providing little or no information on the drug’s mechanism of action (MOA). Gene ... compounds by measuring the activity of molecular pathways. This information can complement phenotypic ...
(Date:5/5/2020)... ... May 05, 2020 , ... Smart ... launch of its iGlucose® LTE Cat-M Cellular Connected Diabetes Blood Glucose ... technology, the industry’s newest and broadest cellular connectivity available, to provide patients with ...
(Date:4/22/2020)... ... April 20, 2020 , ... Global molecular ... today that Omixon’s founder and chairman Dr. Attila Berces returns as CEO. Outgoing ... HLA since 2014 before stepping into the CEO role in 2017. , ...
(Date:4/7/2020)... , ... April 06, 2020 , ... Gateway Genomics ... children, reached 200,000 SneakPeek Early Gender DNA Tests sold in March, just ... was launched as an ecommerce product, where a mom could order her kit online, ...
Breaking Biology Technology:
Cached News: