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Newly identified gut protein kills bacteria

St. Louis, Jan. 26, 2003 -- Researchers at Washington University School of Medicine in St. Louis have discovered a new antibiotic protein that appears to kill certain types of bacteria in the intestine. Their results are published Jan. 27 in the online version of the journal Nature Immunology and are slated for print publication in March.

"These findings were completely unexpected," says Lora V. Hooper, Ph.D., instructor of molecular biology and pharmacology. "We initially thought that this protein might be involved in blood vessel formation. What we discovered, though, is that it's a potent killer of bacteria."

Hooper is first author of the study; Jeffrey I. Gordon, M.D., the Dr. Robert J. Glaser Distinguished University Professor and Head of the Department of Molecular Biology and Pharmacology, led the study.

The team identified a protein called angiogenin 4 (Ang4), which belongs to a class of proteins originally believed to be involved in the development of blood vessels that supply tumors with nutrients. The group discovered that Ang4 was released by specific cells, called Paneth cells, located in the intestinal lining.

Because Paneth cells are known to assist the immune system in defending against infection, the team examined Ang4 to determine how it interacts with a variety of different microbes. They found that the protein killed certain kinds of gut microbes and conclude that Ang4 may be part of an arsenal of microbicidal proteins deployed by Paneth cells to help keep gut bacteria from getting too close to the intestinal lining, where they could cause damage or mount an invasion.

Moreover, the researchers were surprised to find production of Ang4 is controlled by a bacterium that makes its home in the intestine. The microbe, called Bacteroides thetaiotaomicron, is a prominent member of the mouse and human gut microbial community. This makes Ang4 unique, as it is the first example of a protein antibiotic whose expressi
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Contact: Gila Z. Reckess
314-286-0109
Washington University School of Medicine
26-Jan-2003


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