HOME >> BIOLOGY >> NEWS
Newly identified master gene key in baby's first breath

CINCINNATI - Researchers at Cincinnati Children's Hospital Medical Center have identified a master gene that controls the first breath a newborn infant takes. The findings could have implications for treating premature babies and children and adults with lung disease or lung injury.

While other genes have been identified as having roles in lung development, this master gene, called Foxa2, controls key factors that allow the lungs of a fetus to develop fully and eventually breathe air. While Foxa2 was previously known to exist, its role in lung maturation and function at birth were not known.

When Foxa2 is missing in newborn mice, respiratory distress syndrome and in many cases, death, was almost certain to follow, said Jeffrey A. Whitsett, MD, chief of Neonatology, Perinatal and Pulmonary Biology at Cincinnati Children's and senior author of the study that appears in the October 5 issue of the Proceedings of the National Academy of Sciences (PNAS).

"It was surprising to us that a single gene was able to orchestrate so many other aspects of lung function we know are critical for survival at the time of birth. The discovery of this gene and understanding of how it works could lead to new treatments for premature infants and for children and adults who suffer from lung disease or injury," he said.

Because lungs do not fully mature until the last trimester of gestation, when an infant is born prematurely, the lungs are not fully developed and lack the necessary amount of surfactant needed to keep the lungs working properly. Surfactant is a natural chemical found in the lungs that prevents alveoli - the tiny airways in the lungs - from collapsing and in turn allows the lungs to open when the newborn starts to breath. The absence of surfactant causes respiratory distress syndrome within hours of birth.

"We showed that Foxa2 regulates a group of genes that stabilize surfactant production, which is required for the transit
'"/>

Contact: Amy Reyes
amy.reyes@cchmc.org
513-636-9684
Cincinnati Children's Hospital Medical Center
27-Sep-2004


Page: 1 2 3

Related biology news :

1. Newly discovered protein may be key to muscular dystrophy
2. Newly designed nanoparticle quantum dots simultaneously target and image prostate tumors in mice
3. Newly grown kidneys can sustain life in rats
4. Newly discovered gene controls levels of bad cholesterol in mice
5. Newly identified gene linked to brain development
6. Newly cloned gene key to global adaptation of wheat
7. Newly identified genes may help predict outcome in childhood leukemia
8. Newly identified gene may halt fuzzy, moldy fruit
9. Newly found gene resistant to economically crippling wheat disease
10. Newly invented Endometrial Function Test (EFT®) solves the puzzle of unexplained infertility
11. Newly mapped enzyme could yield new treatments for female sexual dysfunction

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/8/2019)... LA JOLLA, Calif. (PRWEB) , ... September 06, ... ... and the Board of Directors of Nanosens Innovations have each authorized the respective ... would become a subsidiary of Cardea, with the Nanosens brand representing a series ...
(Date:8/27/2019)... (PRWEB) , ... August 26, 2019 , ... Shoreline ... to the strain level, has hired Bill McKenzie as its CEO and Karen Woodward ... to help Shoreline Biome meet growing demand for its products and expand the company’s ...
(Date:8/25/2019)... ... 2019 , ... BioInformatics, part of Science and Medicine Group, ... helps connect companies with a network of thousands of life science and medical ... is moving faster than ever, and we have built a qualitative offering to ...
Breaking Biology News(10 mins):
(Date:8/23/2019)... ... August 22, 2019 , ... ... modalities and is scheduled to broadcast 4Q/2019. Check your local listings for more ... patches for generic drug delivery. Focusing on therapeutics for children and the elderly, ...
(Date:8/7/2019)... Ohio (PRWEB) , ... August 07, 2019 , ... Locus ... a breakthrough line of soil amendments (soil “probiotics”), including Rhizolizer ® , which ... a year—the largest impact any approach has offered to date. Results from the treatment ...
(Date:8/4/2019)... ... ... Cirtec Medical Corporation, a strategic outsourcing partner for complex medical devices, including ... a 30,000 sq. ft. manufacturing facility in the Coyol free zone, located in ... is expected to be fully operational by the end of the year, will be ...
(Date:7/19/2019)... ... 18, 2019 , ... World renowned two-time Everest summiter Ravichandran ... California-based charity Coalition Duchenne for its 9th Annual Expedition Mt. Kinabalu in Sabah, ... for Duchenne muscular dystrophy and was founded by Sabahan Catherine Jayasuriya. , ...
Breaking Biology Technology:
Cached News: