HOME >> BIOLOGY >> NEWS
Newly indentified protein linked to cancer cell survival

A team of Vanderbilt-Ingram Cancer Center investigators have identified a new secreted protein and its receptors that appear to give a cancer cell the ability to fuel its own growth and present a potential target for anti-cancer drugs.

Secreted proteins are released from one cell to transmit a signal to another cell instructing a particular behavior such as cell growth, migration or survival. These proteins cannot act alone; they must act through a receptor or receptors on the receiving cell, so discovery of the receptor is also important.

Initially called MOB-5, this new protein has been renamed Interleukin 24 (IL-24), with the approval of the Human Genome Nomenclature Committee, because the investigators work demonstrates relationship to the family of proteins known as interleukins. These proteins are typically secreted by immune system cells in response to a triggering event, such as injury or infection. However, the Vanderbilt-Ingram team has found IL-24 and two receptors expressed in colon cancer cells, making it the first interleukin to be found along with its receptors in tumor cells.

"There is an old saying that cancer is like a wound that never heals," said Peng Liang, Ph.D., associate professor of Cancer Biology, whose laboratory did the work reported this month in the Journal of Biological Chemistry. "This gives credence to that old saying."

Using a process called differential display to compare gene expression between cancer and normal cells, the team found this gene to be expressed only in tumor cells and particularly those in which the oncogene (cancer-causing gene) RAS is activated. RAS is mutated frequently in colon and pancreas cancers, among others, and it appears from this groups work that RAS activation leads to unregulated expression of IL-24 and its receptors.

"At the time, we didnt know it was an interleukin, just that it was a secreted protein," Liang said. "Finding the difference between tumor and normal cells is
'"/>

Contact: Cynthia Manley
cynthia.manley@mcmail.vanderbilt.edu
615-936-5711
Vanderbilt University Medical Center
6-Mar-2002


Page: 1 2

Related biology news :

1. Newly identified master gene key in babys first breath
2. Newly discovered protein may be key to muscular dystrophy
3. Newly designed nanoparticle quantum dots simultaneously target and image prostate tumors in mice
4. Newly grown kidneys can sustain life in rats
5. Newly discovered gene controls levels of bad cholesterol in mice
6. Newly identified gene linked to brain development
7. Newly cloned gene key to global adaptation of wheat
8. Newly identified genes may help predict outcome in childhood leukemia
9. Newly identified gene may halt fuzzy, moldy fruit
10. Newly found gene resistant to economically crippling wheat disease
11. Newly invented Endometrial Function Test (EFT®) solves the puzzle of unexplained infertility

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/24/2017)... March 24, 2017 The Controller General of Immigration ... Abdulla Algeen have received the prestigious international IAIR Award for ... Continue Reading ... ... Deputy Controller Abdulla Algeen (small picture on the right) have received the ...
(Date:3/23/2017)... The report "Gesture Recognition and Touchless Sensing Market by Technology (Touch-based ... to 2022", published by MarketsandMarkets, the market is expected to be worth USD ... 2022. Continue Reading ... ... ...
(Date:3/22/2017)... Lithuania , March 21, 2017   ... and object recognition technologies, today announced the release ... kit (SDK), which provides improved facial recognition using ... cameras on a single computer. The new version ... to improve accuracy, and it utilizes a Graphing ...
Breaking Biology News(10 mins):
(Date:9/19/2017)... ... September 19, 2017 , ... ... outbreak is about to be eliminated, said Lyle Probst, President, CEO and Founder ... technologies different than other pathogen detection solutions, Probst said, “Sample preparation takes ...
(Date:9/19/2017)... ... September 19, 2017 , ... Band-LOK, ... applications, announced today that two new patents have been allowed by the USPTO ... of Band-LOK, said, “We continue to explore additional clinically-relevant designs for both the ...
(Date:9/17/2017)... ... September 17, 2017 , ... ... Korean Ministry of Food and Drug Safety (KMFDS) for an Investigational New Drug ... Middle East Respiratory Syndrome coronavirus (MERS-CoV). The study in Korea represents the second ...
(Date:9/14/2017)... ... September 14, 2017 , ... Boston Strategic Partners, Inc. (BSP), ... Economics and Outcomes Research (HEOR) and ‘big data’ to provide in-depth analysis of ... spending exceeded $3.0 trillion with nearly 1/3 spent on hospitalizations. BSP has access ...
Breaking Biology Technology:
Cached News: