HOME >> BIOLOGY >> NEWS
News tips: Genetics research builds on legacy of double helix

In April 1953, James Watson and Francis Crick published their report describing for the first time the correct, double helical structure of the DNA molecule. Twenty-five years later, Johns Hopkins researchers Hamilton Smith and Daniel Nathans were awarded the Nobel Prize for finding proteins in bacteria that could cut DNA at specific, predictable places, ushering in the era of genetic engineering.

Other researchers at The Johns Hopkins University School of Medicine now are building on the Nathans-Smith and other advances that have dramatically altered medical science. In celebration of these important scientific anniversaries, reporters are invited to pursue the following stories involving genetic approaches to understanding and treating cancer, heart attack, Marfan syndrome, schizophrenia and bipolar disorder.

OXYGEN-RESPONSIVE PROTEIN GIVES INSIGHT TO HEART ATTACK, CANCER

In 1992, Gregg L. Semenza, M.D., Ph.D., a pediatric geneticist with the Johns Hopkins Children's Center and the McKusick-Nathans Institute of Genetic Medicine at Johns Hopkins, isolated hypoxia-inducible factor 1 (HIF-1), a protein that regulates responses to reduced oxygen levels in the body. When oxygen levels drop, HIF-1 accumulates and activates multiple genes that control vital processes, such as red cell production and the formation of new blood vessels, both of which help to increase oxygen delivery throughout the body.

Today, Semenza is investigating the role of HIF-1 in animal models of heart attack, stroke, and cancer -- the three most common causes of death in the United States. This research may lead to the development of therapeutic strategies to promote or inhibit new blood vessel growth in patients, as needed.

"In many patients with coronary artery disease, heart tissue does not respond to reduced blood flow by forming new blood vessels as it should. This may be due, in part, to inadequate production of HIF-1," says Semenza. "If so,
'"/>

Contact: Joanna Downer
jdowner1@jhmi.edu
410-614-5105
Johns Hopkins Medical Institutions
21-Apr-2003


Page: 1 2 3 4

Related biology news :

1. Genetics, alcohol sensitivity, and behavior
2. Genetics mutations resulting in delayed puberty are focus of MCG study
3. Northwesterns Cancer Genetics Program pinpoints gene that increases cancer risk by 26 percent
4. Genetics pioneer from the Bronx wins Gruber Prize
5. Genetics may help solve mysteries of human evolution
6. Genetics, genes and intelligence
7. International experts to present at Plant Genetics 2003
8. Emory School of Medicine teams with deCODE Genetics to study link between genes and disease
9. Mitokor publishes human mitochondrial genome sequencing study - American Journal of Human Genetics
10. Genetics, stress and environmental cues influence relapse drinking
11. USDA establishes Honeybee Genetics and IPM Center

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/28/2020)... (PRWEB) , ... June 25, 2020 , ... In an ... on innovations in accelerated Point of Care Testing solutions (POCT). Check local listings for ... are collected at medical offices and are shipped to labs throughout the country. Results ...
(Date:6/23/2020)... ... June 23, 2020 , ... Kemp ... announced that the company has received ISO9001:2015 certification for the development and ... industries. The decision to pursue ISO9001 accreditation demonstrates Kemp’s commitment to a ...
(Date:6/23/2020)... ... ... The field of quantitation of large molecules or proteins has been around ... the use of mass spectrometry in this field has gained a lot of momentum ... choose which approach to use (LBA or MS)?” In many cases, either technology ...
Breaking Biology News(10 mins):
(Date:7/10/2020)... ... July 08, 2020 , ... Bode Technology, ... of laboratory operations through its COVID-19 testing service, Bode-CARES . Bode-CARES combines ... Bode-CARES provides a turnkey solution that includes a comprehensive collection and ...
(Date:7/10/2020)... ... 2020 , ... Sentien Biotechnologies, Inc., a clinical-stage biotechnology company ... Nissenson, M.D., F.A.C.P., as its Chief Medical Officer. Dr. Nissenson will join ... Dr. Nissenson serves as an Emeritus Professor of Medicine at the David ...
(Date:7/1/2020)... ... 2020 , ... MedShift , a leading medical technology ... obstacles created as a result of COVID-19. As a provider at the forefront ... and medical manufacturers by expanding access to device offerings, technology services, and marketing ...
(Date:6/28/2020)... ... , ... The Indoor Lab, a leading provider of sensor solutions for monitoring ... to ensure cleanliness, distancing and occupancy with its patent pending WipeAway™ technology using Artificial ... provide a health performance index system that scores all aspects of compliance similar to ...
Breaking Biology Technology:
Cached News: