HOME >> BIOLOGY >> NEWS
Next-generation AIDS vaccine for healthy individuals being tested for safety, tolerability at UC Davis

(SACRAMENTO, Calif.) A clinical trial testing the safety and tolerability of two investigational AIDS vaccines for healthy individuals is being launched this week at the UC Davis School of Medicine and Medical Center. The study, which is part of a multi-site clinical trial, will enroll up to 126 individuals nationwide. Ten to 20 participants will be recruited into the UC Davis study.

Known as a Phase I clinical trial, the UC Davis study will test the safety and tolerability of genetically engineered vaccines that have been designed to protect the body against HIV infection. Developed by Merck Research Laboratories, the test vaccines include a piece of HIV known as Gag. These next-generation vaccines are based on the use of DNA and a non-infectious particle known as an adenovirus. Because both vaccines are produced through genetic engineering techniques, they do not contain any live virus and cannot cause HIV infection. The HIV-1 gag DNA vaccine includes a man-made copy of one of the genes from HIV, which will make an immune response to the real HIV. The adenovirus serotype 5 HIV-1 vaccine also contains the same man-made copy of the HIV-1 gene but uses a defective, non-infectious respiratory virus (adenovirus) as a backbone. These test vaccines are designed to stimulate the immune system to develop an immune defense against the HIV proteins.

The goal of this study is to evaluate the effect of these vaccines on the immune systems ability to produce T-cell responses and antibodies against HIV-1, said Thomas Evans, professor and chief of the Division of Infectious Diseases at UC Davis School of Medicine and Medical Center and principal investigator of the study. A secondary goal is to assess whether aluminum phosphate, a common additive to vaccine formulas, improves the immune response.

The trial is a double-blind study, with some participants receiving the test vaccines and some participants receiving a placebo, an inactive substance use
'"/>

Contact: Carole Gan
cfgan@ucdavis.edu
916-734-9047
University of California, Davis - Health System
12-Oct-2001


Page: 1 2

Related biology news :

1. Next-generation biomaterials to help body heal itself
2. Cancer vaccine based on pathogenic listeria bacteria shows promise targeting metastases
3. Pneumococcal vaccine reduces ear infections, pneumonia, new study shows
4. UC Irvine scientists to develop vaccine to combat bioterrorism threat from deadly bacteria
5. First clinical study of new pediatric croup vaccine shows safety, tolerability in adults
6. Protective gene may enhance vaccine responses
7. Protein vaccine fully protects mice from lethal aerosol challenge with ricin toxin
8. New glycan arrays discover autoimmunogenic activities of SARS-CoV: concern over monkey vaccine
9. Growing new breed of vaccine-producing plants to fight human diseases worldwide
10. Childrens Hospital Boston receives more than $10 million to help make smallpox vaccine safer
11. Triple-vaccine strategy stimulates strong HIV-specific immune response in monkeys

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/11/2019)... ... June 12, 2019 , ... ... discovery services, Abveris plans to leverage the Geneious Biologics platform as a premium ... Chief Technology Officer at Abveris, says: “The Geneious team has done an excellent ...
(Date:6/6/2019)... ... June 05, 2019 , ... Ziegler, ... financial advisor to Pathologists Bio-Medical Laboratories (PBM) on its recent acquisition by PathGroup. ... platform that provides services to more than one dozen hospitals and surgery centers ...
(Date:6/4/2019)... ... 04, 2019 , ... Most preclinical EEG visualization platforms offer ... usually based on variations of amplitude, frequency or spike train detection. In the ... to the complexity and variability of the signal, and automation tools are used ...
Breaking Biology News(10 mins):
(Date:5/7/2019)... British Columbia (PRWEB) , ... May 06, 2019 ... ... be a go-to resource for the growing number of repositories being asked to ... We are grateful to the team of contributors who are world leaders, who ...
(Date:5/2/2019)... ... , ... Stay on top of current hot topics through free webinars presented ... webinars is free, so be sure to register today to save your place! Participate ... to see our upcoming webinars: , CLINICAL TRIALS , May 7 – Oncology Clinical ...
(Date:4/18/2019)... ... 18, 2019 , ... Taking a step closer to a ... at Worcester Polytechnic Institute (WPI) has developed a novel process using an unusual ... and other biofuels more economically. , Isobutanol, like ethanol, is an alcohol, but ...
(Date:4/10/2019)... (PRWEB) , ... April 10, ... ... both regenerative medicine manufacturing technology leaders, have locked into multiple agreements to ... before. Companies across the regenerative medicine industry, ranging from synthetic biology companies ...
Breaking Biology Technology:
Cached News: