HOME >> BIOLOGY >> NEWS
Nicotine shows anti-depressant effects in an animal model of depression

The embargo time and date on this release have changed since the release was originally posted on EurekAlert!.

Investigators at Howard University have recently observed the antidepressant effect of nicotine in Wistar-Kyoto (WKY) rats, a putative behavioral model of depression. Drs. Youssef Tizabi and K. Y. Tyler will present their findings at the Experimental Biology 2002 meeting in New Orleans on April 22.

When compared to the general population, individuals with a history of clinical depression are more likely to smoke cigarettes. In addition, depressed patients often encounter difficulty in their smoking cessation efforts, which may partially be attributed to relapsed depressive episodes during withdrawal. Although cigarette smoke contains over 3,000 chemicals, nicotine is the primary constituent that acts on the brain. As a result, scientists have suggested that cigarette smoking may be an attempt by depressed individuals to self-medicate with nicotine.

Depression is a major mental health disorder that is estimated to affect nearly 10 million American adults each year. Treatment of depressive illness, which includes various antidepressant medications and psychotherapy, is effective in 60-80 percent of patients. Despite the relative success of current antidepressant therapies, the precise cause of depression remains unclear. Animal models of depression, such as the WKY rat, are important research tools that can be used to screen potential antidepressant drugs and to study the underlying brain mechanisms involved in depression. These recent findings suggest that nicotine or nicotinic agonists (nicotine-like agents) may have therapeutic potential for the treatment of depressive illnesses. However, researchers insist that the risks associated with cigarette smoking outweigh any potential therapeutic benefits of nicotine contained in this form.

Presently, the neurochemical mechanisms by which nicotine produces
'"/>

Contact: Sarah Goodwin
eb2press@bellsouth.net
770-722-0155
Federation of American Societies for Experimental Biology
20-Apr-2002


Page: 1 2

Related biology news :

1. Nicotine exposure in aging hearts
2. USF study: Nicotine antagonist relieves depression in children with Tourettes
3. Nicotine may have another side effect: heavy drinking
4. Susceptibility Genes For Nicotine Addiction
5. Gene Variant Found That Can Help Protect Against Nicotine Addiction
6. New study shows hope for treating inhalant abuse
7. Chemical derived from vitamin-E shows early promise as cancer drug
8. Cancer vaccine based on pathogenic listeria bacteria shows promise targeting metastases
9. Trial shows which brain cancer patients benefit from temozolomide
10. New research shows plants can shuffle and paste gene pieces to generate genetic diversity
11. Preclinical safety study shows adipose-derived stem cells improve heart function after heart attack

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/23/2017)... ARMONK, N.Y. and ITHACA, N.Y. ... IBM ) and Cornell University, a leader in dairy ... combined with bioinformatics designed to help reduce the chances ... breaches. With the onset of this dairy project, Cornell ... the Consortium for Sequencing the Food Supply Chain, a ...
(Date:5/23/2017)... 2017  Hunova, the first robotic gym for the rehabilitation and functional ... in Genoa, Italy . The first 30 robots will ... USA . The technology was developed and patented at ... IIT spin-off Movendo Technology thanks to a 10 million euro investment from ... click: ...
(Date:5/16/2017)... DALLAS , May 16, 2017   ... for health organizations, and MD EMR Systems ... certified development partner for GE, have established a ... Patient Portal product and the GE Centricity™ products, ... Centricity EMR. These new integrations ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... LAGUNA HILLS, Calif. , Oct. 11, 2017 ... London (ICR) and University of ... prognostic tool to risk-stratify patients with multiple myeloma (MM), in ... nine . The University of Leeds ... by Myeloma UK, and ICR will perform the testing services ...
(Date:10/11/2017)... Tampa Bay, Florida (PRWEB) , ... October 11, ... ... Food and Drug Administration (FDA) has granted orphan drug designation to SBT-100, its ... antibody (sdAb) for the treatment of osteosarcoma. SBT-100 is able to cross the ...
(Date:10/10/2017)... ... October 10, 2017 , ... For the ... won a US2020 STEM Mentoring Award. Representatives of the FirstHand program travelled to ... Experience from US2020. , US2020’s mission is to change the trajectory of STEM ...
(Date:10/10/2017)... Calif. , Oct. 10, 2017 SomaGenics ... from the NIH to develop RealSeq®-SC (Single Cell), expected ... for profiling small RNAs (including microRNAs) from single cells ... Program highlights the need to accelerate development of approaches ... "New techniques for measuring levels ...
Breaking Biology Technology:
Cached News: