HOME >> BIOLOGY >> NEWS
Nicotine shows anti-depressant effects in an animal model of depression

The embargo time and date on this release have changed since the release was originally posted on EurekAlert!.

Investigators at Howard University have recently observed the antidepressant effect of nicotine in Wistar-Kyoto (WKY) rats, a putative behavioral model of depression. Drs. Youssef Tizabi and K. Y. Tyler will present their findings at the Experimental Biology 2002 meeting in New Orleans on April 22.

When compared to the general population, individuals with a history of clinical depression are more likely to smoke cigarettes. In addition, depressed patients often encounter difficulty in their smoking cessation efforts, which may partially be attributed to relapsed depressive episodes during withdrawal. Although cigarette smoke contains over 3,000 chemicals, nicotine is the primary constituent that acts on the brain. As a result, scientists have suggested that cigarette smoking may be an attempt by depressed individuals to self-medicate with nicotine.

Depression is a major mental health disorder that is estimated to affect nearly 10 million American adults each year. Treatment of depressive illness, which includes various antidepressant medications and psychotherapy, is effective in 60-80 percent of patients. Despite the relative success of current antidepressant therapies, the precise cause of depression remains unclear. Animal models of depression, such as the WKY rat, are important research tools that can be used to screen potential antidepressant drugs and to study the underlying brain mechanisms involved in depression. These recent findings suggest that nicotine or nicotinic agonists (nicotine-like agents) may have therapeutic potential for the treatment of depressive illnesses. However, researchers insist that the risks associated with cigarette smoking outweigh any potential therapeutic benefits of nicotine contained in this form.

Presently, the neurochemical mechanisms by which nicotine produces
'"/>

Contact: Sarah Goodwin
eb2press@bellsouth.net
770-722-0155
Federation of American Societies for Experimental Biology
20-Apr-2002


Page: 1 2

Related biology news :

1. Nicotine exposure in aging hearts
2. USF study: Nicotine antagonist relieves depression in children with Tourettes
3. Nicotine may have another side effect: heavy drinking
4. Susceptibility Genes For Nicotine Addiction
5. Gene Variant Found That Can Help Protect Against Nicotine Addiction
6. New study shows hope for treating inhalant abuse
7. Chemical derived from vitamin-E shows early promise as cancer drug
8. Cancer vaccine based on pathogenic listeria bacteria shows promise targeting metastases
9. Trial shows which brain cancer patients benefit from temozolomide
10. New research shows plants can shuffle and paste gene pieces to generate genetic diversity
11. Preclinical safety study shows adipose-derived stem cells improve heart function after heart attack

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/16/2017)...  Veratad Technologies, LLC ( www.veratad.com ), an innovative ... verification solutions, announced today they will participate as a ... thru May 17, 2017, in Washington D.C.,s ... Identity impacts the lives of billions ... evolving digital world, defining identity is critical to nearly ...
(Date:4/18/2017)... , April 18, 2017  Socionext Inc., a global expert ... a media edge server, the M820, which features the company,s hybrid ... software provided by Tera Probe, Inc., will be showcased during the ... the NAB show at the Las Vegas ... ...
(Date:4/11/2017)... Research and Markets has announced the addition of the ... ... to grow at a CAGR of 30.37% during the period 2017-2021. ... been prepared based on an in-depth market analysis with inputs from ... prospects over the coming years. The report also includes a discussion ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... ... October 10, 2017 , ... ... 13 prestigious awards honoring scientists who have made outstanding contributions ... scheduled symposium during Pittcon 2018, the world’s leading conference and exposition for laboratory ...
(Date:10/9/2017)... Jupiter, FL (PRWEB) , ... October 09, 2017 , ... ... episode, scheduled to broadcast first quarter 2018. American Farmer airs Tuesdays at 8:30aET on ... Agriculture industry is faced with the challenge of how to continue to feed a ...
(Date:10/9/2017)... ... October 09, 2017 , ... The Giving ... marijuana products targeting the needs of consumers who are incorporating medical marijuana into ... in Phoenix, Arizona. , As operators of two successful Valley dispensaries, The Giving ...
(Date:10/7/2017)... ... October 06, 2017 , ... ... applications consulting for microscopy and surface analysis, Nanoscience Instruments is now expanding ... offers a broad range of contract analysis services for advanced applications. Services ...
Breaking Biology Technology:
Cached News: